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2 | © Copyright Fresenius Kabi AG
Fresenius – The Health Care Group
Antibodies / Cell Therapies
Dialysis Products Dialysis Care Extracorporeal
Therapies
Infusion Therapy + Generic iv drugs Clinical Nutrition Medical Devices
Operation and management of acute clinics and rehabilitation centers
Technical service for health care facilities
FRESENIUS MEDICAL CARE
FRESENIUS KABI
FRESENIUS HELIOS
FRESENIUS VAMED
FRESENIUS BIOTECH
Fresenius – The Health Care Group Key figures by business Segment: FY 2011
FY 2011
Sales € 9,192 Mn €3,964 Mn € 2.665 Mn € 737 Mn
EBIT € 1,491 Mn € 803 Mn € 270 Mn € 44 Mn
Fresenius
Medical Care
Fresenius
Vamed
Fresenius
Kabi
Fresenius
Helios
5 | © Copyright Fresenius Kabi AG
- No. 1 in infusion and nutrition therapy in Europe
- No. 2 IV product company in USA
- No. 1 in clinical nutrition and artificial colloids in Asia
- No. 1 generic oncology company in many countries
- Oncology
- Surgery
- Emergency
- Intensive Care
- Intensive Care
- Hospital
- Ambulatory Care
Infusion Therapy Clinical Nutrition Medical Devices
e.g. Transfusion Technology
- Blood collection and processing
- Apheresis treatment
Fresenius Kabi Infusion & Nutrition Therapies for Patients in Hospital & Ambulatory Care
6 | © Copyright Fresenius Kabi AG
Segment
Business
Products
Medical Devices
Infusion Therapy – I.V. Drugs / Generics
I.V. Drugs / Generics
Ambulatory Pumps for Oncology and Pain Therapy
Syringe Pumps for Anaesthesia / ICU
Oncology
Anaesthetics & Analgetics
Antibiotics / Antivirals
Critical Care
Fresenius Kabi Infusion Therapy – Intravenously Administered Drugs
7 | © Copyright Fresenius Kabi AG
More than 150 scientists with key functional competencies and
extensive product development experience in India, Europe & US
State-of-the-art research facilities
Strong relationship with leading cancer hospitals for conducting
clinical trials
Global product registration capabilities and experience
Professional in-house IP management skills in EU, US & Asia
Fresenius Kabi Oncology R&D Infrastructure
8 | © Copyright Fresenius Kabi AG
From API to finished drug
Taxus baccata Paclitaxel API 10-DAB
Mappia foetida Camptothecin Irinotecan API
Paclitaxel
Irinotecan
9 | © Copyright Fresenius Kabi AG
Fresenius Kabi Oncology Plantations
Precursors for
Taxanes
Topoisomerase Inhibitors
Etoposide
Vinorelbine
10 | © Copyright Fresenius Kabi AG
Technology: Manufacture of Antineoplastic APIs by
multi step organic synthesis using closed handling with Isolator technology
The site is specialized in Taxol chemistry,
Organoplatinum chemistry and semi synthesis from plant origin molecules
Fresenius Kabi API Production
11 | © Copyright Fresenius Kabi AG
Fresenius Kabi GMP Approved Dosage Form Plants for Oncology drugs in India and USA
OncoShield™
Key Advantages
OncoShield™ (sleeved vials) offers protection against drop breakage
Prevents uncontrolled spilling & confines the spillage area in case of drop breakage Reduces cytotoxic contamination on the outside of the vial
The sleeve is a clear plastic that enables easy inspection of content and label
Protects the label from swabbing while disinfecting the vial
Respects the environment, causing less waste compared to secondary packaging
solutions like containers
Requires no change in vial handling behavior, height of the sleeve is up to middle of the aluminium cap
Safety Color Concept
Key Advantages
Highlight safety color concepts on vial cartons / lables and flip off caps to differentiate
the product / strenghths to avoid admixing errors by the pharmacists / physicians /
paramedics
Bar Codes / 2D Matrix
Key Advantages
Record / Read expiry / use by dates at the point of sale or distribution
Highly useful for traceability and helpful aginst counterfeiting
PRC Packaging / Debossing on tablets
Upper face of the tablets is debossed with the first 3 words of product (e.g. ANA for
Anastrozole tabs, LET for Letrozole tabs and the lower face is deboosed with the
Fresenius Kabi logo
Printing on unit blister (each unit blister is printed with the product details), in case of
any left out individual tablets can be eaisly identified
16 | © Copyright Fresenius Kabi AG
Oncology Portfolio
Injectables Non Injectables
Bleomycin Gemcitabine Anastrozole
Carboplatin Ifosfamide Bicalutamide
Cisplatin Irinotecan Capecitabine
Cladribine Methotrexate Cyclophosphamide
Cyclophosphamide Oxaliplatin
Cytarabine Paclitaxel Imatinib
Docetaxel Topotecan Letrozole
Doxorubicin Vinorelbine Mercaptopurin
Epirubicin Methotrexate
Etoposide Tamoxifen
Fluorouracil Temozolomide
We offer one of the largest oncology portfolios in our industry
17 | © Copyright Fresenius Kabi AG
Qu
ality
/ S
afe
ty /
Co
mp
ati
bilit
y
Oncological
Drugs
i.V.
Drugs Parenteral
Nutrition
Pharmaceutical Substances
Transfer Devices
Spikes Syringes
Compounding Container
Standard
Solutions
Empty
Bags
Disposable
Pumps
Application Devices
Infusion
Pumps
Infusion
Disposables
Fresenius Kabi The I.V. Drug Business
18 | © Copyright Fresenius Kabi AG
Quality
Correct Dosing
Sterile Product
Safety
Avoid needle stitch injuries
Avoid contamination
Compatibility
Drug
i.V. Container
Giving Set
Fresenius Kabi Oncology drug compounding
19 | © Copyright Fresenius Kabi AG
Canada
• Montreal
• Calgary
• Toronto
• Vancouver
Argentina
• Buenos Aires
• Cordoba
Australia
• Melbourne
• Sydney
Norway
• Halden
South Africa
• Johannesburg
• Port Elizabeth
Germany
• Munich, Neufahrn
• Aschaffenburg
UK
• Runcorn
• Bordon
Brazil
• Rio de Janeiro
Austria
• Graz
Chile
• Santiago de Chile
• Concepción
Plants marked in green = Oncology compounding
Malaysia
• Kuala Lumpur
Fresenius Kabi Compounding Plants Worldwide
20 | © Copyright Fresenius Kabi AG
Segment
Business
Products
Medical Devices
Clinical Nutrition
Enteral Nutrition
Administration of liquid nutrition as sip or tube feed via the gastro-intestinal tract
Parenteral Nutrition
Supply of daily nutrient needs via intravenous infusion
Feeding Pumps
Transnasal Tubes
Percutaneous Tubes
Giving / Dressing Sets
Infusion Pumps
Giving Sets
Fresenius Kabi Caring for cancer patients - Enteral & Parenteral nutrition
21 | © Copyright Fresenius Kabi AG
Segment
Business
Products
Medical Devices
Infusion Therapy
Colloids
Colloids are blood volume
substitutes to maintain
blood volume, hemodynamic
circulation and tissue
oxygenation
Standard infusion solutions
Intravenously administered
solutions to compensate loss
of fluids and to balance
electrolytes and acid-bases
Fresenius Kabi Infusion Therapy – Colloids & Basic Solutions
Infusion pumps
Infusion disposables
Venous-Access Devices
22 | © Copyright Fresenius Kabi AG
Segment
Business
Products
Blood Processing Systems
Mixing Scales
Blood Separators
Sterile Connection
Blood Bags and Filters
Standard Blood Bags
Blood Filters
Inline Systems
(Bag Systems including Filters)
Transfusion Technology
Fresenius Kabi Transfusion Technology
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