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This is a presentation on the process of formulating customized cosmeceuticals.
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Custom Cosmeceutical Formulations Utilizing Medical Image Analysis and
Biometric Markers
Robert P. ManzoSkinprint
1997 Rt 17MGoshen, New York 10921
845-294-8501www.skinprint.com
� Mass Customization and Personalization is now common� Automobiles� Clothing� Shoes
� Cosmeceutical Technology & Diagnostics Have Converged� Skin diagnostics have become more user friendly� Medical imaging has become more accessible� Cosmetic active ingredients are efficacious� Consumers are more educated� Demographics are creating demand
Background
3 Types of Pigmentation
.
A specific combination of biometric
measurements and imaging will yield
optimal results in most cases
Imaging
� High resolution macro photography � Color ultraviolet reflectance
photography
Epidermal Biometrics
� Hydration� pH� Elasticity & Firmness� TEWL (Barrier)� Sebum� Melanin and redness
Customized/Personalized Cosmeceutical Formulation
� Wrinkles� Color tone� Stratum corneum texture� Hyper pigmentation root cause
� Oxidative damage� Melasma� Post-inflammatory hyper pigmentation� Melanin banding patterns
� Pore size� Bacterial presence (UV)� Determination of epidermal vs. dermal Melasma (UV)� Product occlusion� Lesion count
Imaging Quantitative Markers
Confidential
Subject with Melasma and minor oxidative damage (sun damage)
Confidential
Subject with Melasma and minor oxidative damage (sun damage) and melanin banding
Bacterial presence
Bacterial presence
Confidential
Product Occlusion
� Hydration� Dose and type of moisturizing ingredient
� pH� Bacterial proliferation (acne root cause)� Too many chemical peels (barrier function impairment)
� Elasticity & Firmness� Type and dose of collagen and elastin initiators� Dose of MMP suppressors
� TEWL (Barrier)� Humectant or occlusive moisturizer� Acne initiator
� Sebum� Acne root cause
� Melanin and redness� Baseline for in office procedures (lasers, peels, etc.)� Rosacea quantification� Healing rates
Epidermal Biometrics
Case Study
� 46 year old subject
� Self described issues� “spots” on face� Under eye darkness and puffiness� Chronic dryness� Skin laxicity
� Medical History� Healthy, non-remarkable� Pre-menopausal� 12 year use of Retin-A
Visible and UVCR Analysis
Subject Biometrics Before Treatment
•Hydration 38.0 >62•pH 5.9 4.5 - 5.5•Elasticity & Firmness 47.0 >60•TEWL (Barrier) 9.0 <3•Sebum 3.0 15 - 25•Melanin 15 (spots = 36) 7 (spots = 22)•redness 46 17
Reading Optimal Range
� Cleanser: anionic surfactant base for thorough cleansing
� 3 dimensional bio-peptide approach� Collagen I & III initiator� Fibril bundling strengthener� Matrix Metalloproteinase inhibitor
� Two phase eye treatment approach� Capillary seal� Chelant for removal of iron (hemoglobin)
� Three phase lightening approach� MSH suppressor� Tyramine competition� Tyrosinase inhibitor
� Treatment Lotion� Liposomal ursolic acid (barrier repair)� Occlusive and humectant moisturizers
Treatment Course
Confidential
Results
� Hydration 38.0 67.0� pH 5.9 5.3� Elasticity & Firmness 47.0 56.0� TEWL (Barrier) 9.0 2.0� Sebum 3.0 4*� Melanin 15 (spots = 36) 8 (spots = 25)� redness 46 17
Before After
Results
Results
1997 RT 17M
Goshen, New York 10924
845-294-8501
www.skinprint.com
Robert Manzo
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