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©2012, Genentech ©2012, Genentech
Green BioPharma: Innovative
Medicines from Sustainable Labs Kristi Budzinski, PhD
Monday, May 19, 2014
©2012, Genentech ©2012, Genentech
Genentech Introduction
Green BioPharma Program
Green Lab Assessments
Findings
Greening the Culture
©2012, Genentech
Genentech Background
Founder of biotechnology industry
Mission: Our goal is to use the power of genetic engineering and advanced
technologies to make medicines that address unmet medical needs, and help millions
of people worldwide. Our commitment to sustainable development respects the
needs of the individual, the society, and the environment.
South San Francisco Headquarters
• 15,000 employees support entire value chain
• Additional manufacturing sites in Vacaville
and Oceanside, CA
Member of Roche Group since 2009
• Robust GNE/Roche clinical development pipeline
• 37 marketed products
• 45 NMEs in clinical trials
• Increased emphasis on corporate
environmental sustainability
3
©2012, Genentech
Corporate Sustainability Goals
11% 10% 50%
SSF Site goals by 2014
20 % energy, water,
and waste reductions
in just 2 years
4
©2012, Genentech
Mission Statement:
• To increase our colleagues’ knowledge and awareness of sustainability
• To provide a forum to generate, exchange, and evaluate sustainability ideas to improve the environmental performance of Genentech's operations, our communities, and our homes
• And to have fun while leading by example in our industry.
Employee Engagement
Grass roots: 2500 members and growing, formed 2002.
6
More green genes members means more
environmentally-conscious scientists!
©2012, Genentech
Environmental Impact of Labs 7
Square foot allocation by area Energy usage by area Total -20/ULT
Freezers
HEEPI July 2011 Detailed results from S-Lab audits
Category Life
Science Chemistry
Office
space
HVAC-related 46% 60% 3%
Space/water
heating 20% 20% 74%
Equipment/
small power 25% 15% 12%
Lighting 10% 5% 11%
Lower campus 321
FRC I & II 482
B27
Freezer farm 170
South campus 482
©2012, Genentech
Sustainability: From the Office to the Lab
Creation of Green BioPharma Program
‒ Inspired by Green Chemistry
‒ Focuses on our core competencies
‒ Develop tools and metrics to influence behavior and decision-
making
Foundations
‒ Scientifically defensible and data driven
‒ Sustainable business process
‒ Engage employees
‒ Encourage innovation
Cross-functional governance structure
‒ Enable leaders to do what’s best for the company and sustainability
‒ Use metrics to drive implementation and build leadership support
8
©2012, Genentech
Definition and Vision
Definition
Green BioPharma is the design, development, and
implementation of biological and chemical products and
processes that reduce or eliminate the use and generation of
substances hazardous to human health and the environment.
9
Vision
• Customers, business partners, and the community regard Genentech as
a leader in efforts that reduce its ecological footprint resulting from
its core competencies.
• Employees continuously innovate, evaluate, and implement ways to
reduce the environmental impact of their decisions and operations.
• Wherever possible, the result of green innovations are quantified.
Green BioPharma forges the bridge between patients, people and
the environment.
©2012, Genentech
Green BioPharma @ GNE: a short timeline
~2009 • Roche Technical Working Group on Green Chemistry established
• 1-2 GNE process chemists involved
• Sponsors lectures and annual process chemistry contest
• Limited exposure to rest of company
Fall 2011 • Green Genes lunch and learn talks by Green Chemistry scientists at UCB
• Great response from employees
• Created a Green Genes subteam
• Launched the Green BioPharma Program
• Hired a Green BioPharma Project Manager
• Established Green BioPharma Steering Committee, as part of Sustainability Council
2012 • Steering Committee endorsed 2012 goals and projects
• Green Genes Subteam ~130 volunteers
2013 • Published a video on this effort
10
©2012, Genentech
Green BioPharma Steering Committee
11
Objectives:
1. Recommend SSF Green
BioPharma projects
2. Provide project guidance
and prioritization
3. Promote employee
innovation in lab and
manufacturing areas
4. Develop and report
performance metrics to
stakeholders
11
©2012, Genentech
Strategic Focus Areas 12
Institutionalize Programs
Engage Leadership and Employees
• Behaviors, decision-making
Develop and Deploy Tools/ Metrics
• Educate stakeholders
• Drive performance
Manage Supply Chain and End-of-
Life
• Streamline procurement and waste decisions
Collaborate with Vendors
• Promote innovation
• Drive higher value services
• Greener products
©2012, Genentech
Green Genes Sub-team
Socialize initiatives within labs
Green Chemistry lecture series
Green Product Lunch and Learns
Test greener products, share data
13
Green Chemistry Task force
13
©2012, Genentech
Green Lab Assessments
Purpose:
1. Collect baseline data on the environmental footprint of different types of laboratories at Genentech
i. Examples: chemistry, molecular biology, quality control, DNA sequencing
2. Engage employees to effect personal or behavioral change through data collection and sharing.
Method:
1. Identify candidate laboratories
2. Present process at group meeting i. Establish lab champion as single point-of-contact
3. Perform assessment and collect data
4. Report feedback with follow-up action items
15
©2012, Genentech
Lab Assessment: The Approach
Impact categories
• Energy usage
• Cold storage
• Waste streams
• Purchasing
5/19/2014
16
©2012, Genentech
Energy Results for Bench-top Equipment
Centrifuges (9/lab)
Cooled centrifuges (2/lab)
17
Vortexers (5/lab) Shakers (2/lab)
Thermomixer or heat block (2/lab) Pipet aides (1pp)
VS
EquipmentAverage
power (W)
Typical
usage
(hrs/yr)
Energy
consumption per
unit (kWh/yr)
# units per
lab
Est. total energy
consumed by lab
(kwH/yr)
Estimated Cost
per unit
($/yr)
Estimated Cost
per lab
($/yr)
Water bath @37C5 8760 42 2 84 $11.76 $23.52
CO2 Incubator @ 37C 130 8760 1139 2 2278 $318.86 $637.73
Thermal cycler 120 1500 180 1 180 $25.20 $25.20
Ultracentrifuge (benchtop) 109 8760 955 1 955 $133.68 $133.68
Centrifuge 10 8760 88 9 788 $110.38 $993.38
Cooled centrifuge 30 8760 263 2 526 $73.58 $147.17
Heat block @ 42 10 8760 88 2 175 $24.53 $49.06
Total $697.99 $2,009.73
©2012, Genentech
Bench-top Centrifuge Case study 18
Standby
energy
difference is
0.0024 kWh
0.00014 kWh
0.0026 kWh
Avg power consumption
Week 1: 0.072 kWh/day
Week 2: 0.062 kWh/day
Yearly savings: 3.65 kWh
or 5.7 lbs CO2 per unit!
©2012, Genentech
Cold Storage Metrics for GNE Labs 19
1455+ total freezers on campus
Raising all freezers to -70 would
save the CO2 emissions
equivalent to 39 homes.
Unplugging freezers <10%
full would be equivalent to
taking 74 cars off the road.
©2012, Genentech
Freezer Footprint Reduction Campaign 20
50% have an
online or written
inventory system
for contents
35% conduct a
periodic freezer
clean-out
> 50% plan to
purchase new
freezers within 3
years
Cu
rren
t sta
te
Fu
ture
sta
te
>70% have an
online inventory
system for
contents
Lab
Cleanouts
include a freezer
clean-out
>40% of labs
share freezer
space
New freezers are
energy efficient
Stirling freezers
©2012, Genentech
Non-hazardous Lab Waste Metrics
Compostable 37%
Recyclable lab plastics/PPE
26%
Actual landfill
22%
Mixed paper 9% Cardboard
3%
Bottles/cans
5%
B5 waste forensics data Current collection systems
1 trash can
per person
0.5 recycling bin
per person
Avg 45-50
pairs/ week
(400-450 g)
21
©2012, Genentech
Lab Purchasing Habits
Cataloging lab supply stocks guides
greener product recommendations
22
©2012, Genentech
Create a Sharing Economy: Surplus Chem Recycling
24
Inventory and
storage
Lab
Clean-outs Donate
excess
chemicals
24
1. Lower the activation energy for participation!
2. Create system that mimics current business process as closely as possible.
3. Advertise, advertise, advertise.
1 global Roche award!
Inspire Sustainable
Behavior Award
>$10,000
saved!
330
containers
purchased
415
items in
stock
©2012, Genentech
Green Chemistry Committee: Better Solvent Selection 26
Resulted in 2014
Dept Goal:
Reduce use of
dichloromethane
(DCM) by 25%.
©2012, Genentech
Reducing Laboratory Landfill Waste 27
Make it easy, available, and applicable
Add additional streams as necessary
©2012, Genentech
Encouraging Greener Lab Supply Choices
Reuse before buying new!
Reuse, less packaging, and safer
products where appropriate!
28
©2012, Genentech
Greener Instrumentation Initiatives
Center for Advanced Light Microscopy (CALM) core microscopy resource for Genentech Research
CALM has found LED systems to be bright, stable and reliable
- Equivalent or lower exposure times
- Intensity stable over time
- Reduced energy usage
Commitment to replace all Hg-based light sources by 2016
29
LEDs Eliminate:
• > $7000/year in bulb costs
• Disposal cost and time
• Surprise bulb failures
In partnership with:
©2012, Genentech
Roadmap for Successful Organizational Change 30
Steering Committee sets goals that align with program
mission
Program Manager researches and identifies potential initiatives and
early adopters
Prospective initiatives are tested within scientific
communities
Necessary groups, depts., etc. connected to provide resources --products, staff,
publicity, etc -- for initiative
Steering Committee helps achieve senior management support for
initiative
Track initiative progress, collect data, and communicate results
“Successful” initiative turned over to stakeholders and becomes embedded
in program, process, procedure
©2012, Genentech
Effecting Individual Change 31
Empower labs to
make better choices
Provide data to
support
recommendations
Use early adopters to
gain institutionally
relevant data
Mimic current
business processes
Gain leadership
support Recognize efforts
©2012, Genentech
Acknowledgements
Participating Labs
Jane Grogan
Jacob Corn
Erin Deuber
Media Prep B6, B10,
B48
Ira Mellman Labs
Vishva Dixit
Kathy Kozak
Pamela Chan
32
Green BioPharma
Steering Committee
Tina Larson, PTDU
Tse-Sung Wu, EHS
Stefan Koenig, SMPC
Jacob Corn, EDB
Ekta Mahajan, PD Eng
Debbie O’Conner, CCPP
Joe Jerkins, IMP QS
Bonnie Shum, MSAT
Site Services
EHS
Sustainability
Clean Harbors
Facilities
Cool Ops
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