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Oxford Textbook of RheumatologyFourth EditionEdited by Richard A. Watts, Philip G. Conaghan, Christopher Denton, Helen Foster, John Isaacs, and Ulf Müller-Ladner

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    PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). Oxford University Press, 2015. All RightsReserved. Under the terms of the l icence agreement, an individual user may print out a PDF of a single chapter of a title in OxfordMedicine Online for personal use (for details see Privacy Policy). Subscriber: Cristian Ninulescu; date: 16 July 2015

    Publisher: OxfordUniversityPress PrintPublicationDate: Oct2013PrintISBN-13: 9780199642489 Publishedonline: Oct2013DOI: 10.1093/med/9780199642489.001.0001

    OxfordMedicineOnline

    OxfordTextbookofRheumatology(4ed.)EditedbyRichardA.Watts,PhilipG.Conaghan,ChristopherDenton,HelenFoster,JohnIsaacs,andUlfMller-Ladner

    LatestupdateInNovember2014,80chapterswereupdated.NumerousupdateshavebeenmadeincludingtothechaptersonRheumatoidArthritis,theGeneticsandEnvironmentsection,theManagementsection,andmuchmore.WealsowelcometwonewauthorsSebastienViatteandCharlesRaine.

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    EngyAbdelattifDepartmentofOsteoarticularPathologyManchesterMedicalSchoolManchesterRitaAbdulkaderNorfolkandNorwichUniversityNHSFoundationTrustNorwichShaziaAbdullahDepartmentofRheumatologyHinchingbrookeHospitalHinchingbrookeParkHuntingdon

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    AbhishekAbhishekDepartmentofRheumatologyQueenElizabethHospitalUniversityHospitalBirminghamNHSTrustBirminghamMarioAbinunChildren'sBMTUnitNewcastleGeneralHospitalNewcastleuponTyneJoAdamsFacultyofHealthSciencesUniversityofSouthamptonHighfieldSouthamptonAdeAdebajoAcademicRheumatologyGroupUniversityofSheffieldMedicalSchoolSheffieldTehseenAhmedRoyalNationalHospitalforRheumaticDiseasesNHSFoundationTrustUpperBoroughWallsBathJonathanD.AkikusaRheumatologyServiceDepartmentofGeneralMedicineRoyalChildren'sHospitalParkville,VictoriaAustraliaDanielAletahaDivisionofRheumatologyDepartmentofInternalMedicine3MedicalUniversityViennaViennaAustriaAdilAl-NahhasImperialCollegeHealthcareTrustHammersmithHospitalLondonIsmaelAtchiaNorthTynesideGeneralHospitalNorthShieldsTyneandWearEileenBaildamAlderHeyChildren'sNHSFoundationTrustEatonRoadAlderHey

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    LiverpoolJyotiBakshiRheumatologyDepartmentRoyalBerkshireHospitalReadingS.BalamoodyBiomedicalImagingInstituteUniversityofManchesterManchesterThomasBardinUniversitParisVIIServicedeRheumatologieHopitalLariboisireParisFranceAnneBartonArthritisResearchUKEpidemiologyUnitUniversityofManchesterManchesterNunoBatistaDepartmentofSpinalDisordersNuffieldOrthopaedicCentreOxfordThomasBeckingsaleNorthofEnglandBoneandSoftTissueTumourServiceFreemanHospitalNewcastleUponTyneDavidBendingRheumatologyUnitUCLInstituteofChildHealthLondonMikeBenjaminEmeritusProfessorSchoolofBiosciencesUniversityofCardiffCardiffMichaelW.BeresfordDepartmentofWomen'sandChildren'sHealthInstituteofTranslationalMedicine,UniversityofLiverpoolDepartmentofPaediatricRheumatologyAlderHeyChildren'sNHSHospitalFoundationTrustLiverpoolJessicaBertrandInstituteofExperimentalMusculoskeletalMedicineUniversityHospitalMunsterMunsterGermany

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    AshokK.BhallaRoyalNationalHospitalforRheumaticDiseasesNHSFoundationTrustUpperBoroughWallsBathKuljeetBhamraRheumatologyDepartmentNuffieldOrthopaedicCentreOxfordMarcBijlDepartmentofInternalMedicineandRheumatologyMartiniHospitalGroningenTheNetherlandsJohannesW.J.BijlsmaDepartmentofRheumatologyandClinicalImmunologyUniversityMedicalCentreUtrechtUtrechtTheNetherlandsFraserBirrellInstituteofCellularMedicineMusculoskeletalResearchGroupTheMedicalSchoolNewcastleUniversityNewcastleuponTyneNickBishopAcademicUnitofChildHealthDepartmentofHumanMetabolismUniversityofSheffieldSheffieldChildren'sHospitalSheffieldJulianBlakeDepartmentofClinicalNeurophysiologyNorfolkandNorwichUniversityHospitalNorwichDavidA.BongInstitutoPoaldeReumatologiaBarcelonaSpainSimonBowmanRheumatologyDepartmentQueenElizabethHospitalBirminghamB152TH,UKWilliamH.BreidahlRoyalPerthHospitalPerthWesternAustraliaAustralia

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    PaulA.BroganUniversityCollegeLondonInstituteofChildHealthandGreatOrmondStreetHospitalNHSTrustLondonBarbaraM.BrkerErnst-Moritz-Arndt-UniversittGreifswaldInstitutfrImmunologieundTransfusionsmedizinAbteilungImmunologieGreifswaldGermanyMatthewBrownUniversityofQueenslandDiamantinaInstituteTranslationalResearchInstitutePrincessAlexandraHospitalWoolloongabba,BrisbaneQueenslandAustraliaPhilipM.BrownMusculoskeletalResearchGroupInstituteofCellularMedicineNewcastleUniversityNewcastleuponTyneKayBruneDepartmentofExperimentalandClinicalPharmacologyandToxicologyFAUErlangen-NurembergErlangenGermanyHermineI.BrunnerDivisionofRheumatologyChildren'sHospitalMedicalCenterCincinnatiOhioChristopherBuckleyRheumatologyResearchGroupCentreforTranslationalInflammationResearchSchoolofImmunity&InfectionCollegeofMedical&DentalSciencesUniversityofBirminghamResearchLaboratoriesQueenElizabethHospitalBirminghamGerd-R.BurmesterDepartmentofRheumatologyandClinicalImmunologyCharit-UniversittsmedizinBerlinFreeUniversityandHumboldtUniversityBerlinBerlinGermanyFrankButtgereitClinicforRheumatologyandClinicalImmunologyCharit-UniversittsmedizinBerlin

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    BerlinGermanyLoretoCarmonaUniversidadCamiloJoseCelaVillafrancadelCastilloMadridSpainGraemeJ.CarrollSchoolofMedicineUniversityofNotreDameAustralia;andFremantleHospitalWesternAustraliaHectorChinoyTheUniversityofManchesterManchesterAcademicHealthScienceCentreSalfordRoyalNHSFoundationTrustSalfordAlvinaD.ChuDivisionofImmunologyandRheumatologyStanfordUniversitySchoolofMedicineStanfordCAJuliaClarkPaediatricInfectiousDiseasesInfectionManagementandPreventionServiceRoyalChildren'sHospitalBrisbaneAustraliaSophieCleanthousCentreforRheumatologyResearchDivisionofMedicineUniversityCollegeLondonLondonJacquiClinchBristolRoyalHospitalforChildrenBristolLauraC.CoatesLeedsInstituteofRheumaticandMusculoskeletalMedicineUniversityofLeedsandLeedsNIHRMusculoskeletalBiomedicalResearchUnitLeedsTeachingHospitalsNHSTrustLeedsJ.GerryCoghlanCardiologyDepartmentRoyalFreeHospitalLondonHelenCohenDeptofRheumatologyRoyalNationalOrthopaedicHospitalStanmoreMiddlesex

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    PhilipG.ConaghanLeedsInstituteofRheumaticandMusculoskeletalMedicineUniversityofLeedsandNIHRLeedsMusculoskeletalBiomedicalResearchUnitLeedsCyrusCooperMRCLifecourseEpidemiologyUnit,UniversityofSouthampton;andNIHRMusculoskeletalBiomedicalUnit,UniversityofOxford,OxfordRobertG.CooperTheUniversityofManchesterManchesterAcademicHealthScienceCentreSalfordRoyalNHSFoundationTrustSalfordAndrewP.CopeHead,AcademicDepartmentofRheumatologyCentreforMolecularandCellularBiologyofInflammationDivisionofImmunology,InfectionandInflammatoryDiseasesKing'sCollegeSchoolofMedicineKing'sCollegeLondonNicolaDalbethBoneandJointResearchGroupDepartmentofMedicineUniversityofAucklandGrafton,AucklandNewZealandBhaskarDasguptaDepartmentofRheumatologySouthendUniversityHospitalNHSFoundationTrustWestcliff-on-SeaEssexCosimoD.BariInstituteofMedicalSciencesUniversityofAberdeenAberdeenChrisDeightonDepartmentofRheumatologyRoyalDerbyHospitalDerbyAngeloDelBuonoDepartmentofRheumatologyUniversityCampusBiomedicoRomeItalyChristopherP.DentonCentreforRheumatologyandConnectiveTissueDiseasesDepartmentofInflammation

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    DivisionofMedicine,UCLMedicalSchoolRoyalFreeCampusLondonStanleyC.DeresinskiRedwoodCityCaliforniaIdaDzifaDeyRheumatologyDepartmentUniversityCollegeLondonHospitalLondonRobertDinserJustus-LiebigUniversityGiessenInternalMedicineandRheumatologyKerckhoff-KlinikGmbHBadNauheimGermanyMichaelDohertyAcademicRheumatologyUniversityofNottinghamNottingham,UKRadboudDolhainDepartmentofRheumatologyErasmusMCUniversityMedicalCentreRotterdamTheNetherlandsThomasDrnerMed.Klinikm.S.RheumatologieundKlinischeImmunologieandDRFZBerlinBerlinGermanyTilmanDrekeInsermERI-12UFRdeMdecine/PharmacieUniversitdePicardieJulesVerneAmiensFranceCiarnM.DuffyMaxKeepingWingChildren'sHospitalofEasternOntarioOttawa,OntarioCanadaLisaDunkleyDepartmentofRheumatologyRoyalHallamshireHospitalSheffieldChristopherEdwardsDepartmentofRheumatology

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    SouthamptonUniversityHospitalsNHSTrustSouthamptonGeneralHospitalSouthamptonMarkH.EdwardsMRCLifecourseEpidemiologyUnitUniversityofSouthamptonSouthamptonGeneralHospitalSouthamptonHermannEinseleUniversityHospitalWrzburgInternalMedicineIIWrzburgGermanyDespinaEleftheriouInstituteofChildHealthLondonAssiaEljaafariDepartmentofClinicalImmunologyandRheumatologyHpitalEdouardHerriotUniversityofLyonLyonFranceBenjaminEllisDepartmentofRheumatologyKing'sCollegeHospitalDenmarkHillLondonEdzardErnstComplementaryMedicinePeninsulaMedicalSchoolExeterDevonSteveEyreCentreforMusculoskeletalResearchInstituteforInflammationandRepairFacultyofMedicalandHumanSciencesUniversityofManchesterManchesterJeremyFairbankDepartmentofSpinalDisordersNuffieldDepartmentofOrthopaedics,RheumatologyandMusculoskeletalSciencesNuffieldOrthopaedicCentreOxfordSaulN.FaustWellcomeTrustClinicalResearchFacilityUniversityofSouthamptonSouthampton

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    EugenFeistClinicforRheumatologyandClinicalImmunologyCharit-UniversittsmedizinBerlinBerlinGermanyJeremyFieldConsultantinTraumaandOrthopaedicsCheltenhamGeneralHospitalCheltenhamMaxFieldWolfsonMedicalSchoolBuildingUniversityofGlasgowGlasgowFranciscoFigueiredoDepartmentofOphthalmologyRoyalVictoriaInfirmaryNewcastleUniversityNewcastleuponTyneAndrewFilerSchoolofImmunityandInfectionMRCCentreforImmuneRegulationCollegeofMedicalandDentalSciencesUniversityofBirminghamEdgbastonBirminghamVolkerFingerleBavarianHealthandFoodSafetyAuthorityOberschleiheimGermanyRoyFleischmannUniversityofTexasSouthwesternMedicalCenterDallasTXJoanneFooRheumatologyDepartmentYorkDistrictHospitalYorkHelenFosterMusculoskeletalResearchGroupNewcastleUniversityMedicalSchoolNewcastleuponTyneAmyFoulkesTheDermatologyCentreSalfordRoyalNHSFoundationTrustManchesterAnthonyJ.FreemontSchoolofClinicalandLaboratorySciences

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    UniversityofManchesterManchesterKlausFrommerJustus-LiebigUniversityGiessenInternalMedicineandRheumatologyKerckhoff-KlinikGmbHBadNauheimGermanyKarlGaffneyDepartmentofRheumatologyTheNorfolk&NorwichUniversityHospitalNHSFoundationTrustUKMariaGalindoRheumatologyDepartmentHospitalUniversitario12deOctubreMadridSpainClareGaltonDepartmentofNeurologyIpswichHospitalNHSTrustIpswichJ.S.HillGastonDivisionofRheumatologyDepartmentofMedicineUniversityofCambridgeCambridgeSteffenGayDepartmentofRheumatologyUniversityHospitalZurichZurichSwitzerlandPaulGeneverDepartmentofBiologyUniversityofYorkYorkCraigGerrandNorthofEnglandBoneandSoftTissueTumourServiceFreemanHospitalNewcastleUponTyneHelenaGleesonDepartmentofEndocrinologyLeicesterRoyalInfirmaryLeicesterCarolineGordonSchoolofImmunityandInfectionCollegeofMedicalandDentalSciences

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    TheMedicalSchoolUniversityofBirminghamEdgbastonBirminghamAndrewGrahamDepartmentofNeurologyIpswichHospitalNHSTrustIpswichRodneyGrahameDepartmentofRheumatologyUniversityCollegeHospitalLondonAndrewJ.GraingerRadiologyDepartmentandLeedsMusculoskeletalBiomedicalResearchCentreChapelAllertonHospitalLeedsTeachingHospitalsLeedsDamianGriffinClinicalSciencesResearchInstituteWarwickOrthopaedicsWarwickMedicalSchoolCoventryChristopherGriffithsDermatologyCentreSalfordRoyalNHSFoundationTrustUniversityofManchesterManchesterAlexeiA.GromCincinnatiChildren'sHospitalMedicalCenterDivisionofRheumatologyCincinnatiOhioWolfgangL.GrossDepartmentofRheumatologyandClinicalImmunologyVasculitisCenterUniversityHospitalSchleswigHolsteinLbeckGermanyMonicaN.GuptaRheumatologyDepartmentGartnavelGeneralHospitalGlasgowRichardHaighDept.ofRheumatologyRoyalDevonandExeterFoundationTrustExeterAlanJ.Hakim

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    ConsultantRheumatologistandAcutePhysicianHonorarySeniorLecturerBartsHealthNHSTrustLondonPhilipHamannRoyalNationalHospitalforRheumaticDiseasesUpperBoroughWallsBathJohnHamburgerUniversityofBirminghamSchoolofDentistryBirminghamJenniferHamiltonQueenElizabethHospitalGatesheadTyneandWearLouiseHamiltonDepartmentofRheumatologyTheNorfolk&NorwichUniversityHospitalNHSFoundationTrustNorwichNicholasC.HarveyMRCLifecourseEpidemiologyUnitUniversityofSouthamptonSouthamptonGeneralHospitalSouthamptonPhilipN.HawkinsNationalAmyloidosisCentreDivisionofMedicineUCLMedicalSchoolRoyalFreeCampusLondonMarloesHeijstekUniversityMedicalCentreWilhelminaChildren'sHospitalDepartmentofPaediatricImmunologyandRheumatologyUtrechtTheNetherlandsMarianneHeitzmannInstituteofExperimentalMusculoskeletalMedicineUniversityHospitalMunsterMunsterGermanyPhilipS.HelliwellLeedsInstituteofRheumaticandMusculoskeletalMedicineUniversityofLeeds,LeedsMartinaHennigerAgaplesionFrankfurterDiakonieKlinikengGmbHAgaplesionMarkusKrankenhaus

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    AkademischesLehr-KHderGoethe-UniversittFrankfurtGermanyArianeHerrickTheUniversityofManchesterManchesterAcademicHealthScienceCentreSalfordRoyalNHSFoundationTrustSalfordSarahHewlettDepartmentofNursingandMidwiferyUniversityoftheWestofEnglandBristolGeoffHideDepartmentofRadiologyFreemanHospitalNewcastleuponTyneAnneHinksArthritisResearchUKEpidemiologyUnitManchesterAcademicHealthScienceCentreTheUniversityofManchesterManchesterBurkhardHinzInstituteofToxicologyandPharmacologyUniversityofRostockRostockGermanyJuliaU.HolleDepartmentofRheumatologyandClinicalImmunologyVasculitisCenterUniversityHospitalSchleswigHolsteinLbeckGermanyRosemaryJ.HollickAberdeenRoyalInfirmaryForesterhillAberdeenKateL.HollidayArthritisResearchUKEpidemiologyUnitTheMedicalSchoolManchesterChristopherR.HolroydMRCLifecourseEpidemiologyUnitUniversityofSouthamptonSouthamptonGeneralHospitalSouthamptonLindseyHooperSolentNHSTrust

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    UniversityofSouthamptonFacultyofHealthSciencesSouthamptonSusanHopkinsDepartmentofMicrobiologyDivisionofMedicine,UCLMedicalSchoolRoyalFreeCampusLondonKristinHoughtonDivisionofRheumatologyDepartmentofPediatricsUniversityofBritishColumbiaVancouverCanadaRachelK.HoylesOxfordCentreforRespiratoryMedicineChurchillHospitalOxfordGrahamR.V.HughesHeadoftheLupusCentre,LondonBridgeHospitalLondonFrancesHumbyCentreforExperimentalMedicineandRheumatology2ndFloor,JohnVaneScienceCentreWilliamHarveyResearchInstituteBartsandtheLondonSchoolofMedicineandDentistryQueenMaryUniversityofLondonLondonJenniferHumphriesDepartmentofRadiologyFreemanHospitalNewcastleuponTyneJohnD.IsaacsMusculoskeletalResearchGroupInstituteofCellularMedicineNewcastleUniversityNewcastleuponTyneDavidIsenbergDepartmentofInflammationUCLDivisionofMedicineLondonJohannesW.G.JacobsDepartmentofRheumatologyandClinicalImmunologyUniversityMedicalCenterUtrechtUtrechtTheNetherlandsDeepakR.Jadon

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    RoyalNationalHospitalforRheumaticDiseasesNHSFoundationTrustUpperBoroughWallsBathSharmilaJandialMusculoskeletalResearchGroupNewcastleUniversityMedicalSchoolNewcastleuponTyneDavidJayneVasculitisandLupusClinicAddenbrooke'sHospitalCambridgeKarlJohnsonRadiologyDepartmentBirminghamChildren'sHospitalBirminghamMariaJuarezRheumatologyResearchGroupSchoolofImmunityandInfectionCollegeofMedicalandDentalScienceUniversityofBirminghamBirminghamDavidKaneAdelaideandMeathHospitalDublinRepublicofIrelandLesleyKayMusculoskeletalServicesDirectorateTheNewcastleuponTyneHospitalsNHSFoundationTrustandMusculoskeletalResearchGroupNewcastleUniversityAndrewKeatRheumatologyDepartmentNorthwickParkHospitalHarrowMiddlesexGregoryJ.KeirInterstitialLungDiseaseUnitRoyalBromptonHospitalLondonCliveKellyQueenElizabethHospitalGatesheadTyneandWearCarolA.KemperPaloAltoMedicalFoundation

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    MountainViewCaliforniaPatrickKestevenDepartmentofHaematologyFreemanHospitalHighHeatonNewcastleuponTyneMuntherA.KhamashtaDirectorofGrahamHughesLupusResearchLaboratoryDivisionofWomen'sHealthKing'sCollegeLondonLondonYukikoKimuraPediatricRheumatologyDivisionJosephMSanzariChildren'sHospitalHackensackUniversityMedicalCenterHackensackNewJerseyStefanKluzekRheumatologyDepartmentNuffieldOrthopaedicCentreOxfordAdelheidKorbInstituteofExperimentalMusculoskeletalMedicineUniversityHospitalMunsterMunsterGermanyAndreasKrauseDepartmentofRheumatologyImmanuelKrankenhausBerlinBerlinGermanyThomasKriegUniversityofCologneCologneGermanyAnoopKuttikatDepartmentforRheumatologyAddenbrooke's,CambridgeUniversityHospitalsCambridgeHelenJ.LachmannNationalAmyloidosisCentreDivisionofMedicineUCLMedicalSchoolRoyalFreeCampusLondonJoannaLedinghamDepartmentofRheumatology

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    QueenAlexandraHospitalCoshamPortsmouthMylesLewisDivisionofGeneticsandMolecularMedicineKingsCollegeLondonGuy'sHospitalLondonMarkLillicrapDepartmentofRheumatologyHinchingbrookeHospitalHuntingdonPeterE.Lipsky1545LondonRoadCharlottesvilleVirginiaChrisLittleHand&UpperLimbSurgeryUnitNuffieldOrthopaedicCentreOxfordUniversityHospitalsNHSTrustOxfordMarkLittleTrinityHealthKidneyCentreTrinityCollegeDublinTallaghtHospitalDublinBereniceLopezDepartmentofChemicalPathologyHarrogateDistrictHospitalHarrogateDanielJ.LovellCincinnatiChildren'sHospitalMedicalCenterCincinnatiOhioRaashidLuqmaniRheumatologyDepartmentNuffieldOrthopaedicCentreOxfordAlexMacGregorNorwichMedicalSchoolUniversityofEastAngliaNorwichPeterJ.MaddisonEmeritusProfessorofMusculoskeletalMedicineUniversityofWales,BangorNicolaMaffulliCentreforSportsandExerciseMedicineBartsandtheLondonSchoolofMedicineandDentistryLondon;DepartmentofMusculoskeletalMedicineandSurgery,SalernoUniversitySchoolof

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    MedicineandSurgery,Salerno,ItalyBernhardMangerDepartmentofMedicineIIIUniversityHospitalErlangenErlangenGermanyTarnyaMarshallNorfolkandNorwichUniversityNHSFoundationTrustNorwichNorfolkAlbertoMartiniIRCCSG.GasliniPediatriaII,Reumatologia,PRINTOGenovaItalyHelenaMarzo-OrtegaLeedsInstituteofRheumaticandMusculoskeletalMedicineUniversityofLeedsandLeedsNIHRMusculoskeletalBiomedicalResearchUnitLeedsTeachingHospitalsNHSTrustLeedsJustinMasonVascularSciencesImperialCentreforTranslationalandExperimentalMedicineImperialCollegeLondon,HammersmithHospitalLondonLorenA.MathesonCentreforPracticeChangingResearchChildren'sHospitalofEasternOntarioOttawa,OntarioCanadaWilfriedMauInstitutsfrRehabilitationsmedizinMedizinischeFakulttMartin-Luther-UniversittHalle-WittenbergHalleGermanyHayleyMcBainCentreofHealthServicesResearchSchoolofHealthSciencesCityUniversityLondonLondonJohnMcBethArthritisResearchUKEpidemiologyUnitTheMedicalSchoolManchesterCandyMcCabeBathCentreforPainServices

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    RoyalNationalHospitalforRheumaticDiseasesFoundationTrustUpperBoroughWallsBathLizaMcCannAlderHeyChildren'sNHSFoundationTrustLiverpoolAndrewMcCaskieTraumaandOrthopaedicSurgeryFreemanHospitalHighHeatonNewcastleuponTyneJanetE.McDonaghBirminghamChildren'sHospitalNHSFoundationTrustBirminghamDennisMcGonagleLeedsInstituteofRheumaticandMusculoskeletalMedicineUniversityofLeedsandLeedsNIHRMusculoskeletalBiomedicalResearchUnitLeedsTeachingHospitalsNHSTrustLeedsUKLauraMcGregorCentreforRheumaticDiseaseGlasgowRoyalInfirmaryGlasgowNeilMcHughRoyalNationalHospitalforRheumaticDiseasesUpperBoroughWallsBathIanMcNabHand&UpperLimbSurgeryUnitNuffieldOrthopaedicCentreOxfordUniversityHospitalsNHSTrustOxfordEsperanzaMerinoDepartmentofInfectiousDiseasesUniversidadMiguelHernandezHospitalGeneralUniversitariodeAlicanteSpainSonjaMerkesdalDivisionofClinicalImmunologyandRheumatologyWorkingGroupforHealthEconomicsandClinicalEpidemiologyHannoverMedicalSchoolHannoverGermanyMaribelI.MiguelHumanAnatomyandEmbryologyUnitDepartmentofExperimentalPathologyandTherapeutics

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    UniversityofBarcelonaL'HospitaletdeLlobregatSpainKirstenMindenGermanRheumatismResearchCentre,BerlinEpidemiologyUnit,ChildrensuniversityhospitalCharit-UniversittsmedizinBerlinBerlinGermanyPierreMiossecDepartmentofClinicalImmunologyandRheumatologyHpitalEdouardHerriotUniversityofLyonLyonFranceAnnaMistryRheumatologyDepartmentNuffieldOrthopaedicCentreOxfordPiaMoinzadehDepartmentofRheumatologyRoyalFreeHospitalLondonIngridMllerInstitutoPoaldeReumatologiaBarcelonaSpainUlfMller-LadnerJustus-LiebigUniversityGiessenKerckhoffKlinikBadNauheimGermanyJoachimMller-QuernheimDepartmentofPneumologyUniversityMedicalCentreFreiburgFreiburgGermanySaraswathiMurthyDepartmentofInfectiousDiseasesDivisionofMedicine,UCLMedicalSchoolRoyalFreeCampusLondonStanleyJ.NaidesQuestDiagnosticsNicholsInstituteImmunologySanJuanCapistranoCalifornia

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    MichelNeidhartCenterofexperimentalRheumatologyUniversityHospitalZurichZurichSwitzerlandElenaNeumannJustus-LiebigUniversityGiessenInternalMedicineandRheumatologyKerckhoff-KlinikGmbHBadNauheimGERMANYStantonNewmanCentreofHealthServicesResearchSchoolofHealthSciencesCityUniversityLondonLondonWan-FaiNgMusculoskeletalResearchGroupInstituteofCellularMedicineUniversityofNewcastleNewcastleuponTyneKiranNistalaRheumatologyUnitUCLInstituteofChildHealthLondonEleanaNtatsakiDepartmentofRheumatologyNorfolkandNorwichUniversityHospitalNorwichAnneO'BrienSchoolofHealthandRehabilitationKeeleUniversityKeeleJaniceO'ConnellSunderlandHospitalSunderlandTyneandWearPhilipJ.O'ConnorDepartmentofclinicalradiologyandLeedsMusculoskeletalBiomedicalResearchUnitChapelAllertonHospitalLeedsOlabamboOgunbambiHullYorkMedicalSchoolHullRoyalInfirmaryHullJohnK.OlynykDepartmentofGastroenterology

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    FremantleHospitalFremantle,WAAustralia;InstituteforImmunology&InfectiousDiseasesMurdochUniversityMurdoch,WAAustralia;CurtinHealthInnovationResearchInstituteCurtinUniversityBentley,WAAustraliaCateH.OrteuRoyalFreeHospitalLondonMonikastensenDepartmentofRheumatologySrlandetHospitalKristiansandNorwayAndrewJ.K.strDepartmentofRheumatologyCambridgeUniversityHospitalsNHSFoundationTustAddenbrookesHospitalCambridgeThomasPapInstituteofExperimentalMusculoskeletalMedicineUniversityHospitalMunsterMunsterGermanyEliseoPascualDepartmentofRheumatologyUniversidadMiguelHernandezHospitalGeneralUniversitariodeAlicanteSpainYusufI.PatelHullYorkMedicalSchoolHullRoyalInfirmaryHullDorothyPattisonStMabynCornwallHarryPetrushkinDepartmentofMedicalandNeuro-OphthalmologyMedicalEyeUnitStThomas'HospitalLondonMatthewC.PickeringCentreforComplementandInflammationResearch

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    DepartmentofMedicineImperialCollegeLondonHammersmithCampusLondonClarissaPilkingtonDepartmentofRheumatologyGreatOrmondStreetHospitalLondonNicolPipitoneUnitadiReumatologiaOspedalediReggioEmiliaReggioEmiliaItalyCostantinoPitzalisCentreforExperimentalMedicineandRheumatology2ndFloor,JohnVaneScienceCentreWilliamHarveyResearchInstituteBartsandtheLondonSchoolofMedicineandDentistryQueenMaryUniversityofLondonLondonPhilipPlattRheumatologyDepartmentFreemanHospitalHighHeatonNewcastle-upon-TyneAntjePrasseDepartmentofPneumologyUniversityMedicalCentreFreiburgFreiburgGermanyElizabethPriceDepartmentofRheumatologyGreatWesternHospitalsNHSFoundationTrustSwindonKariPuolakkaLappeenrantaCentralHospitalLappeenrantaFinlandHelgaRadnerDivisionofRheumatologyDepartmentofInternalMedicine3MedicalUniversityViennaViennaAustriaStuartH.RalstonMolecularMedicineCentreInstituteofGeneticsandMolecularMedicine

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    WesternGeneralHospitalEdinburghAthimalaipetV.RamananPaediatricRheumatologyBristolRoyalHospitalforChildrenBristolSaaehaRauzAcademicUnitofOphthalmologyCollegeofMedicalandDentalSciencesUniversityofBirminghamBirminghamAngeloRavelliPediatriaII,ReumatologiaIstitutoG.GasliniGenovaItalyGerryRaymanTheDiabetesCentreIpswichHospitalsNHSTrustIpswichAnthonyC.RedmondLeedsInstituteofRheumaticandMusculoskeletalMedicineUniversityofLeedsandLeedsNIHRMusculoskeletalBiomedicalResearchUnitLeedsTeachingHospitalsNHSTrustLeedsDavidReesDepartmentofHaematologicalMedicineKing'sCollegeLondonSchoolofMedicineKing'sCollegeHospitalNHSFoundationTrustLondonStefanRehartAgaplesionFrankfurterDiakonieKlinikenGmbHAgaplesionMarkusKrankenhausAkademischesLehr-KHderGoethe-UniversittFrankfurtGermanyDavidM.ReidMedicalSchoolUniversityofAberdeenForesterhillAberdeenLuisRequenaDepartmentofDermatologyFundacinJimnezDazMadridSpainGrahamRiley

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    SchoolofBiologicalSciencesUniversityofEastAngliaNorwichMarkRobertsDepartmentofNeurologySalfordRoyalHopeHospitalSalfordJoannaRobsonRheumatologyDepartmentNuffieldOrthopaedicCentreOxfordEdwardRoddyArthritisResearchUKPrimaryCareCentrePrimaryCareSciencesKeeleUniversityKeeleGerhardRoglerDivisionofGastroenterologyandHepatologyUniversityHospitalZurichZurichSwitzerlandEmmaL.RowbothamRadiologyDepartmentRoyalUnitedHospitalsBathMartinRudwaleitEndokrinologikumBerlinandCharitUniversityMedicineBerlinGermanyGuillermoRuiz-IrastorzaDepartmentofInternalMedicineHospitaldeCrucesUniversityoftheBasqueCountryBilbaoSpainNicolinoRupertoIstitutoG.GasliniPediatriaII,Reumatologia,PRINTOGenovaItalySarahRyanTheHaywoodHospitalBurslemStokeonTrentAlanSalamaUCLCentreforNephrologyRoyalFreeHospital

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    LondonBenazirSaleemRheumatologyDepartmentYorkDistrictHospitalYorkCarloSalvaraniUnitadiReumatologiaOspedalediReggioEmiliaReggioEmiliaItalyHans-GeorgSchaibleDepartmentofPhysiologyFriedrich-SchillerUniversityofJenaJenaGermanyGeorgSchettDepartmentofInternalMedicine3UniversityofErlangen-NuremburgErlangenGermanyBenjaminE.SchreiberRheumatologyDepartmentRoyalFreeHampsteadNHSTrustLondonDavidG.I.ScottNorfolkandNorwichUniversityHospitalNHSTrustNorwichandNorwichMedicalSchool,UniversityofEastAnglia,NorwichDavidL.ScottDepartmentofRheumatologyKing'sCollegeLondonSchoolofMedicineWestonEducationCentreLondonMichaelP.SeedMedicinesResearchGroupSchoolofSportHealthandBioscienceUniversityofEastLondonLondonEmireSeyahiUniversityHospitalCerrahpasaMedicalFacultyUniversityofIstanbulAksarayIstanbulTurkeySanjeevSharmaDepartmentofEndocrinologyandDiabetesPeterboroughandStamfordHospitalsNHSFoundationTrust

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    PeterboroughNicholasShenkerDepartmentforRheumatologyAddenbrooke's,CambridgeUniversityHospitalsCambridgeJoachimSieperDepartmentofRheumatologyCharitCampusBenjaminFranklinBerlinGermanyTuulikkiSokkaJyvskylCentralHospitalJyvskylFinlandJeremySokoloveInternalMedicineandRheumatologyVAPaloAltoHealthCareSystemPaloAltoCaliforniaTauntonR.SouthwoodBirminghamChildren'sHospitalNHSFoundationTrustandtheCollegeofMedicalandDentalSciencesUniversityofBirminghamBirminghamCathySpeedc/oCambridgeLeaHospitalImpingtonCambridgeCorneliaM.SpiesDepartmentofRheumatologyandClinicalImmmunologyCharit-UniversittsmedizinBerlin,CampusMitteBerlinGermanyMilesStanfordMedicalEyeUnitStThomas'sHospitalLondonAndrewSteerDepartmentofGeneralMedicineRoyalChildren'sHospitalMelbourneParkville,VictoriaAustraliaVibekeStrandDivisionofImmunology/RheumatologyStanfordUniversitySchoolofMedicinePaloAltoCaliforniaRainerH.Straub

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    DepartmentofInternalMedicine1UniversityHospitalRegensburgRegensburgGermanyPriyaSukhtankarWellcomeTrustSouthamptonGeneralHospitalSouthamptonCordSunderktterDepartmentofDermatologyUniversityHospitalofMnsterMnsterGermanyDeborahP.M.SymmonsCentreforMusculoskeletalResearchInstituteofInflammationandRepairUniversityofManchesterManchesterMarkTaylorBioengineeringScienceResearchGroupSchoolofEngineeringScienceUniversityofSouthamptonHighfieldSouthamptonElkeTheanderRheumatologyDepartmentUniversityHospitalMalmLundUniversityLundSwedenRanjenyThomasUQDiamantinaInstitutePrincessAlexandraHospitalWoolloongabba,QueenslandAustraliaBenThompsonFreemanHospitalHighHeatonNewcastleuponTynePaulThompsonPooleHospitalNHSFoundationTrustPooleWendyThomsonArthritisResearchUKEpidemiologyUnitManchesterAcademicHealthScienceCentreTheUniversityofManchesterManchester

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    ClareThorntonVascularSciencesImperialCentreforTranslationalandExperimentalMedicineImperialCollegeLondon,HammersmithHospitalLondonLindaTroebergTheKennedyInstituteofRheumatologyUniversityofOxfordOxfordLoriB.TuckerDivisionofRheumatologyDepartmentofPediatricsUniversityofBritishColumbiaVancouver,BCCanadaCarlTuressonDepartmentofRheumatologySkneUniversityHospitalMalmSwedenPatrickJ.TwomeyClinicalBiochemistryTheIpswichHospitalIpswichAlanTyndallDepartmentofRheumatologyUniversityHospitalBaselBaselSwitzerlandNeilUpadhyayDepartmentofTraumaandOrthopaedicSurgeryBristolRoyalInfirmaryBristolAnaValdesDepartmentofTwinResearchKing'sCollegeLondonLondonSandervanAssenDepartmentofinternalmedicine,divisionofinfectiousdiseasesUniversityMedicalCenterGroningenGroningenTheNetherlandsJacobM.vanLaarMusculoskeletalResearchGroupInstituteofCellularMedicineNewcastleUniversityNewcastleuponTyne

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    PietvanRielRadboudUniversityNijmegenMedicalCentreNijmegenTheNetherlandsAnnibaleVersariUnitadiMedicinaNucleareOspedalediReggioEmiliaReggioEmiliaItalyToniaL.VincentTheKennedyInstituteofRheumatologyUniversityofOxfordArjanVissinkDepartmentofOralandMaxillofacialSurgeryUniversityofGroningenUniversityMedicalCenterGroningenGroningenTheNetherlandsReinhardE.VollDepartmentofRheumatologyandClinicalImmunologyUniversityofFreiburgFreiburgGermanyTimVyseDivisionofGeneticsandMolecularMedicineKingsCollegeLondonGuy'sHospitalLondonDavidWalkerMusculoskeletalUnitFreemanHospitalNewcastleuponTyneKarenWalker-BoneMRCLifecourseEpidemiologyUnitSouthamptonGeneralHospitalTremonaRoadSouthamptonPeterWallHospitalHealthSciencesWarwickMedicalSchoolClinicalSciencesResearchLaboratoriesCoventryDavidA.WalshArthritisResearchUKPainCentreAcademicRheumatologyUniversityofNottinghamClinicalSciencesBuildingCityHospital

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    NottinghamLouiseWatsonNIHRAcademicClinicalLecturerInstituteofTranslationalMedicineUniversityofLiverpoolRichardA.WattsDepartmentofRheumatologyIpswichHospitalNHSTrustIpswichLucyR.WedderburnRheumatologyUnitUCLInstituteofChildHealthLondonAtholU.WellsRoyalBromptonHospitalLondonClaireY.J.WenhamLeedsInstituteofRheumaticandMusculoskeletalMedicineUniversityofLeedsandLeedsNIHRMusculoskeletalBiomedicalResearchUnitLeedsTeachingHospitalsNHSTrustLeedsSarahWestlakeRheumatologyDepartmentPooleHospitalNHSTrustPooleRossWilkieArthritisResearchUKPrimaryCareCentrePrimaryCareSciencesKeeleUniversityKeeleAnitaWilliamsDirectorateofProsthetics,OrthoticsandPodiatryCollegeofHealthScienceUniversityofSalfordSalfordFrancesM.K.WilliamsDepartmentofTwinResearchKing'sCollegeLondonLondonElspethWiseEncompassHealthcareTheGalleriesHealthCentreWashingtonTyneandWearRogerWolmanDepartmentofRheumatologyandSportandExerciseMedicineRoyalNationalOrthopaedicHospitalBrockleyHill

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    StanmoreMiddlesexB.P.WordsworthNationalInstituteforHealthResearchOxfordMusculoskeletalBiomedicalResearchUnitNuffieldDepartmentofOrthopaedicsRheumatologyandMusculoskeletalSciences(UniversityofOxford)NuffieldOrthopaedicCentreOxfordJaneWorthingtonCentreforMusculoskeletalResearchInstituteforInflammationandRepairFacultyofMedicalandHumanSciencesUniversityofManchesterManchesterNicoWulffraatDepartmentofPaediatricImmunologyUniversityMedicalCentreUtrechtUtrechtTheNetherlandsMatthewWyseUniversityHospitalsCoventryandWarwickshireUniversityHospitalCoventryHasanYaziciUniversityHospitalCerrahpasaMedicalFacultyUniversityofIstanbulAksarayIstanbulTurkeyKanakoYoshidaAberdeenRoyalInfirmaryForesterhillAberdeenSebahattinYurdakulUniversityHospitalCerrahpasaMedicalFacultyUniversityofIstanbulAksarayIstanbulTurkeyImeneZerizerDepartmentofNuclearMedicineTheRoyalMarsdenHospitalSurreyAngelaZinkEpidemiologyUnitDeutschesRheuma-Forschungszentrum

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    BerlinGermanyGernotZisselDepartmentofPneumologyUniversityMedicalCentreFreiburgFreiburgGermanyFrancescoZulianDepartmentofPaediatricsUniversityofPaduaPaduaItaly