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Frequency of COP cells in control mice (caALK2)
#1 #2 #3 #4 Average (%)
Baseline(WT)
undetectable 0.34 0.17
Baseline(caALK2)
0.25 0.25
Day 2 0.21 0.20 0.21
Day 7 0.92 0.40 0.84 0.52 0.67
Day 14 0.44 0.36 0.27 0.48 0.38
Control mice: received Ade-Cre and cardiotoxin but no treatment
Baseline: no injection
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baseline day 2 day 7 day 14
COP cells
COP cells in patients with fractures
• Objective - to measure the frequency of COP cells in
patients with fracture(s) - COP cells in acute fracture phase (within 7
days after the fracture) vs. in stable phase (in 12 weeks after the fracture)
- longitudinal comparison within subjects
COP cells in fracture patient #1
71 yo female, samples obtained on day 1 after right femoral fracture, no significant co-morbidity
COP cells in fracture patient #2
51 yo male, samples obtained on day 2 after left humeral fracture
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