Epstein-Barr Virus Brittany Seyler. What is it? Herpes virus that infects B Cells and Epithelial...

Epstein-Barr Virus

Brittany Seyler

What is it?

• Herpes virus that infects B Cells and Epithelial cells- linked to malignancies in both

• Responsible for Infectious Mononucleosis

• 2nd most common

BackgroundNamed after M. Anthony Epstein and

Yvonne Barr in 1961

Humans are the only known reservoir

TransmissionSaliva

Blood transfusions

Infects 95% of the world’s population

90% of US population infected by age 25

Symptoms •Fever

•Fatigue

•Sore throat

•Swollen lymph glands

•Weight Loss

•Vomiting

•Hemolysis

Demographics

• Occurs worldwide• No racial predilection• Occurs earlier in

females than males

Structure Crystal structure

Linear, double stranded DNA

“spikes”

Viral envelope easily damaged

Toroidal shaped core

Representation Of Immuno response vs viral incubation.

•Each Line Plot represents different antigens to the EBV over the incubation period of the virus as a whole.

•This scaling can be used in the testing of carriers, and previous carriers of the EBV

Viral Detail•Family:Herpesviridae

•Subfamily:Gammaherpesvirinae

•Genus:Lymphocryptovirus

•Species:Human herpesvirus 4 (HHV-4)

•Associated with several forms of cancer, lymphoma in HIV patients, and believed to be associated with higher risks of autoimmune conditions in those affected.

Prevention

Sources

http://www.cdc.gov/ncidod/diseases/ebv.htmhttp://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001617/http://emedicine.medscape.com/article/963894-overviewhttp://www.pnas.org/contenthttp://www.nature.com/nsmb/journalhttp://virus.stanford.edu/herpes/transmission.htmlhttp://bioweb.uwlax.edu

Thank You :)