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EPIGENOMICS CORE
Epigenomics Core Biomedical Research Core Facilities
MSRB II 25681150 W. Medical Center DriveAnn Arbor, MI 48109-0674
OVER
The Epigenomics Core provides sample quality control, library preparation and sequencing for the study of cytosine and histone modifications.
Products & ServicesWe offer a wide variety of services in epigenomics and bioinformatics resources, including:
• Genome-wide DNA Methylation Profiling
❍ Whole-genome bisulfite sequencing: whole-genome base-pair resolution quantification of DNA methylation
❍ ERRBS (Enhanced Reduced Representation Bisulfite Sequencing): Quantitative base-pair measurement of cytosine methylation at ~3M CpGs genome-wide located at promoters, CpG islands and shores, and intergenic regulatory regions
❍ meDIP-seq: Antibody-based method for identification of mC-enriched areas across the genome.
❍ Support with data analysis
• Targeted (locus-specific) DNA Methylation
❍ Primer design consultation and training
❍ Bisulfite conversion of DNA and PCR amplification of target sequences
❍ MassARRAY EpiTYPER sequencing
❍ Pyrosequencing
❍ Support with data analysis
• Chromatin Modification: ChIP-Seq
❍ Library preparation of user-provided immunoprecipitated DNA ChIP-seq data analysis
❍ Histone Modification by ChIP-Seq (limited initial availability)
• Hydroxymethylation
❍ Genome-wide and Target Specific
Email the Core to set up a consultation, including a FREE initial consultation to scope
your project and ascertain how best to your meet your specific project needs.
From top-notch library preparation and sample quality controls to expert analysis, the Epigenomics Core strives to offer the best in epigenomics and bioinformatics resources.
– Claudia Lalancette, Ph.D., Managing Director, Epigenomics Core
Coming soon to the Core• Chromatin Accessibility
Cost Estimates & FeesFor project-specific costs and fees, please contact the Core.
About the BRCFThe BRCF, part of the University of Michigan Medical School Office of Research, is a collection of centralized labs and services offering state-of-the-art instruments, resources and expertise to biomedical researchers, investigators and educators.
For more information on the BRCF, visit research.med.umich.edu/brcf
Dana DolinoyPh.D., Faculty Director
Claudia LalancettePh.D., Managing Director
734-764-2223
Maureen SartorPh.D., Faculty Bioinformatics Director
Karthik R PadmanabhanPh.D., Senior Bioinformatics Analyst
Sonoko NatsumeSenior Research Lab Technician
CONTACT US
BIOMEDICAL RESEARCH CORE FACILITIESUniversity of Michigan Medical School
2570 MSRB II • 1150 W. Medical Center DriveAnn Arbor, MI 48109-5674
734-647-4776brcf-umms@umich.edu
Hours & LocationOpen Monday-Friday8:30 a.m.- 4:30 p.m.MSRB II 25681150 W. Medical Center DriveAnn Arbor, MI 48109-0674epigenomicscore@umich.edu
research.med.umich.edu/ epigenomicscore
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