Effectiveness and Safety of Tranexamic Acid in Reducing Blood Loss in Total Knee Arthroplasty: A...

Effectiveness and Safety of Tranexamic Acid in Reducing Blood Loss in Total Knee Arthroplasty: A Meta-Analysis

by Zhi-Gao Yang, Wei-Ping Chen, and Li-Dong Wu

J Bone Joint Surg AmVolume 94(13):1153-1159

July 3, 2012

©2012 by The Journal of Bone and Joint Surgery, Inc.

The amount of blood loss per patient was significantly less in the tranexamic acid group compared with the placebo group (weighted mean difference, −504.90 mL [95% CI, −620.89 to

−388.92 mL]; p < 0.00001).

Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153-1159

©2012 by The Journal of Bone and Joint Surgery, Inc.

The number of blood transfusions per patient was significantly less in the tranexamic acid group compared with the placebo group (weighted mean difference, −1.43 units [95% CI, −1.69 to −1.17

units]; p < 0.00001).

Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153-1159

©2012 by The Journal of Bone and Joint Surgery, Inc.

The rate of patients requiring transfusion was significantly less in the tranexamic acid group compared with the placebo group (OR, 0.16 [95% CI, 0.10 to 0.25]; p < 0.00001).

Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153-1159

©2012 by The Journal of Bone and Joint Surgery, Inc.

The rate of deep-vein thrombosis was not affected for the tranexamic acid group as compared with the placebo group (OR, 0.75 [95% CI, 0.34 to 1.67]; p = 0.48).

Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153-1159

©2012 by The Journal of Bone and Joint Surgery, Inc.

The rate of pulmonary embolism was not affected for the tranexamic acid group as compared with the placebo group (OR, 0.65 [95% CI, 0.18 to 2.33]; p = 0.50).

Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153-1159

©2012 by The Journal of Bone and Joint Surgery, Inc.

Prothrombin time was not affected for the tranexamic acid group as compared with the placebo group (weighted mean difference, −0.04 second [95% CI, −0.33 to 0.24 second]; p = 0.77).

Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153-1159

©2012 by The Journal of Bone and Joint Surgery, Inc.

Activated partial thromboplastin time was not affected for the tranexamic acid group as compared with the placebo group (weighted mean difference, 0.37 second [95% CI, −0.56 to 1.29

seconds]; p = 0.44).

Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153-1159

©2012 by The Journal of Bone and Joint Surgery, Inc.