Dr. Kevin Ahern - Oregon State...

Metabolic Energy

Dr. Kevin Ahern

Metabolic  Energy

Metabolic  Energy

Metabolic  Energy

Metabolic  Energy

Metabolic  Energy

Metabolic  Energy

Metabolic  Energy

For aA ⇄ bB

Metabolic  Energy

For aA ⇄ bB

∆G = ∆G°’ + RTln([B]b/[A]a)

Metabolic  Energy

For aA ⇄ bB

∆G = ∆G°’ + RTln([B]b/[A]a)

For aA + cC ⇄ bB + dD

Metabolic  Energy

For aA ⇄ bB

∆G = ∆G°’ + RTln([B]b/[A]a)

For aA + cC ⇄ bB + dD

∆G = ∆G°’ + RTln{([B]b[D]d)/([A]a[C]c)}

Metabolic  Energy

For aA ⇄ bB

∆G = ∆G°’ + RTln([B]b/[A]a)

For aA + cC ⇄ bB + dD

∆G = ∆G°’ + RTln{([B]b[D]d)/([A]a[C]c)}

∆G = ∆G°’ + RTln({Products}/{Reactants})

Metabolic  Energy

For A <=> B

Metabolic  Energy

For A <=> B

if ΔG is negative, A->B is favored

Metabolic  Energy

For A <=> B

if ΔG is negative, A->B is favoredif ΔG is positive, B-> A is favored

Metabolic  Energy

For A <=> B

if ΔG is negative, A->B is favoredif ΔG is positive, B-> A is favored

if ΔG is 0, B-> A and A-> B are equally favored

Metabolic  Energy

For A <=> B

if ΔG is negative, A->B is favoredif ΔG is positive, B-> A is favored

if ΔG is 0, B-> A and A-> B are equally favoredAt ΔG = 0, the system is at equilibrium

Metabolic  Energy

Metabolic  Energy

Metabolic  Energy

Muscle Energy

Metabolic  Energy

Muscle EnergyCreatine Kinase

Metabolic  Energy

Muscle EnergyCreatine Kinase

Creatine + ATP <=> Creatine Phosphate + ADP

Metabolic  Energy

Muscle EnergyCreatine Kinase

Creatine + ATP <=> Creatine Phosphate + ADP

ΔG0' = +12 kJ/mol

Metabolic  Energy

Metabolic  Energy

Metabolic  Energy

Metabolic  Energy

Metabolic  EnergyNicotinamide

Metabolic  EnergyNicotinamide

Adenine

Metabolic  EnergyNicotinamide

Adenine

Din

ucle

otid

e

Din

ucle

otid

e

Din

ucle

otid

e

Din

ucle

otid

e

Metabolic  Energy

Coupled  Reactions  

Glucose  +  Pi  <=>  Glucose-­‐6-­‐Phosphate                  ΔG°’  =  +14  kJ/mol  Glucose  +  ATP  <=>  Glucose-­‐6-­‐Phosphate            ΔG°’  =  -­‐16.5  kJ/mol

Metabolic  Energy

Metabolic  Pathways

Metabolic  Pathways

Metabolic  Pathways

Metabolic  Pathways

ΔG°’  Values  of  Hydrolysis  (kJ/mol)  

PEP  =  -­‐61.9  1,3  BPG  =  -­‐49.4  

Creatine  Phosphate  =  -­‐43.1  ATP  to  ADP  =  -­‐30.5  

G1P  =  -­‐20.9  Pyrophosphate  =  -­‐19.3

Metabolic  Pathways

Metabolic  Melodies

Metabolic  Melodies

Oh Delta G (To the tune of "Oh Danny Boy")

Copyright Kevin Ahern

Oh Delta G (To the tune of "Oh Danny Boy")

Copyright Kevin Ahern

Oh Delta G - the change in Gibbs free energy Can tell us if a process will advance

'Cause if the value's less than naught it translates that Reverse reactions haven't got a chance

 But when the sign is plus it is the opposite

And then the backwards happens all the time A factor is the standard Gibbs free energy

So don't forget about the delta G naught prime

Metabolic  Melodies

Metabolic  Melodies

The Muscle Energy Song

(to the tune of “I Will”) Copyright © Kevin Ahern

The Muscle Energy Song

(to the tune of “I Will”) Copyright © Kevin Ahern

For running and for jumping

You need some energy

Chemically the body stores it

In the form of ATP

If backup should be needed

Reserves are there in wait

Muscles brimming with supplies of

Tiny creatine phosphate

Ready whenever cells are ever

Needing to exercise

Steady as ever when whatever

Energy needs arise

The action is exacting

For leaping in the air

Myofibrils all contracted

Using energy extracted

From reactions that react in me

Using A-T-P

You see