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Biolo ški mehanizmi regulacija - Fiziologija kardiovaskularnog sistema -. Aterogeneza: značaj lipidskih poremećaja i oksidativnog stresa. Novi faktori rizika za ishemijsku bolest srca. Doc. Dr Zvezdana Kojić Decembar 2004. Atherosclerosis: a multifactorial disease. - PowerPoint PPT Presentation
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Aterogeneza: značaj lipidskih poremećaja i
oksidativnog stresa.
Novi faktori rizika za ishemijsku bolest srca
Doc. Dr Zvezdana Kojić
Decembar 2004.
Biološki mehanizmi regulacija- Fiziologija kardiovaskularnog sistema -
Atherosclerosis:a multifactorial disease
Arterial wall:structure and function
Different stages of atherosclerotic plaquedevelopment
Vascular endothelium modificationin atherosclerosis
Plaque formation
1 — Fatty streak
Plaque formation
2 — Fibrous cap
Plaque formation
3 — Lipid core
Lipid core constitutionActivated macrophages accumulate lipids
Lipid core constitutionLDL oxidation
Parietal vascular inflammationThe activated macrophage produces
inflammatory cytokines
From plaque to thrombosis, key event: plaque rupture
Plaque vulnerability
Key role of macrophages
Vulnerable plaqueKey role of the macrophage in vascular wall inflammation
Fibrinogen is an independent risk factorfor atherosclerosis
Vulnerable plaqueKey role of the macrophage in the degradation
of the fibrous cap
Tissue factor: the initiator of coagulation and thrombogenesis in vivo
Tobacco and atherosclerosis
Dyslipidemia and atherosclerosis
Novi faktori rizika
• ADMA ?
• homocistein
• grelin, leptin
• mokraćna kiselina
• Mg++, Fe++, Zn++, Cu++
Literatura
• Li AS., Glass CK. PPAR and LXR-dependent pathways controlling lipid metabolism and development of atherosclerosis. J Lip Res., 2004, 45(12): 2161-73.
• Francois M, Kojda G. Effect of hypercholesterolemia and of oxidative stress on the nitric oxide-cGMP pathway. Neurochem Int. 2004 Nov;45(6):955-61.
• Bursill CA, Choudhury RP, Ali Z, Greaves DR, Channon KM. Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout mice. Circulation, 2004, 110(16): 2460-6.
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