Disentangling hippocampal and amygdala contribution to ... · s s Disentangling hippocampal and...

Copyright © 2019 the authors

Research Articles: Behavioral/Cognitive

Disentangling hippocampal and amygdalacontribution to human anxiety-like behaviour

https://doi.org/10.1523/JNEUROSCI.0412-19.2019

Cite as: J. Neurosci 2019; 10.1523/JNEUROSCI.0412-19.2019

Received: 21 February 2019Revised: 25 August 2019Accepted: 29 August 2019

This Early Release article has been peer-reviewed and accepted, but has not been throughthe composition and copyediting processes. The final version may differ slightly in style orformatting and will contain links to any extended data.

Alerts: Sign up at www.jneurosci.org/alerts to receive customized email alerts when the fullyformatted version of this article is published.

Disentangling hippocampal and amygdala

contribution to human anxiety-like

behaviour

Running head: Hippocampus and amygdala in human anxiety-like behaviour

Dominik R Bach1, 2 *Martina Hoffmann3, Carsten Finke3,4, Rene Hurlemann5,6, Christoph J.

Ploner3

Figures: 5

Tables: 3

Introduction:

Discussion:

Abstract

Significance statement

Introduction

Methods

Participants.

Table 1.

Patient

Age Sex Lesion Etiology Clinical note

Figure 1:

Design & procedure: approach/avoidance conflict task.

figure 1

see figure 3

Design & procedure: safe predator exposure task 2 (HC study).

Design & procedure: memory test.

figure 3

Data analysis.

Decision to approach:

Approach and return latency:

Comparison between patients:

Accounting for memory impairment and other confounds:

Safe predator exposure task:

�pcom t w pexGauss t w pT t t

�pexGauss t

ex e ex ex terfc ex t

T2

mle.m

Results

Figure 2.

Healthy control participants' behaviour is similar to previous reports

Table 2:

Action (proportion approach) Approach latency Return latency

F df epsilon p F df p F df p

Recollection of threat memory

Figure 3.

HC but not amygdala lesions impact on approach decision

Table 3:

< .001*

0.033*

0.011*

Figure 4.

Selective HC and amygdala but not MTL lesions may impact on approach latency

Amygdala/MTL but not selective HC lesions impact on return latency

MTL lesions impact on response generation but not on subjective task structure

Figure 5.

w w

Discussion

Acknowledgements

References