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ard S Hui1, Josephadiology, Medical

ODUCTION: Thweeks after yo

aneous remyelined by demyelinas have demonstonal Kurtosis Im

onal information branes, organellestructural compleis metrics provid

opment15 and in dand white matter HODS: A total ofd mouse chow elination. The conystem. A respiratlice thickness=1

ent direction (0.5axial (K//) and ra

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al (vHP)) were murements betweeLTS & DISCUSS

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ment). The axial dared to that of ed only in the bCstages of patholoaxial diffusion ch

ogical correlation┴ showed signifis cortical demyeexity not only in with demyelinatimalities in grey m

Diffusionah A Helpern, 1, DavUniversity of Sout

United St

he cuprizone mooung adult mice ation occurs2,3.

ation associated trated the patho

maging (DKI) is a beyond that pro

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CC. Also, the nont the entire CC indegree of demydiffusivity λ// wasNC, and the K//

CC. Since axonaogy (before 4 wehanges (at 10 wen. A striking resuicant changes (elination and reawhite matter, buon induced by c

matter.

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al Kurtosis Detvid Guilfoyle2, Scoth Carolina (MUSCtates, 3Dementia R

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ROI measuremeone treated (CPZ)s: corpus callosum

caudal (pCC)), col (dHP) and ventra

andard deviations.

tects Cortical ott Gerum2, CaixiaC), Charleston, SC

Research, Nathan K

well characterizhe copper chelademylination is pal response3,4. Rein cuprizone mochnique that exte4. Since non-Ga

xtracellular and intion to white matissue type, and The main goal o

s in the cuprizonmice were used Bis(cyclohexanonntained on a nornce was used fo

mage resolution=ctional anisotropfrom the DKI dat

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was considered apresentative b0 im

se brain. Solochment of different y reduced FA ansion metrics showThese diffusion at this phase (

he bCC, but decnd for decrease

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y the non-Gausse cortex of the accumulation5, catter. In summaronstrating the sig

ents of diffusion ) and control (NC)m (rostral (aCC), mortex (CT) and al (vHP)); * p < 0.0

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zed animal modetor cuprizone (b

predominantly foecently, cortical

ouse model6-11. Hends DTI and quaussian diffusionntracellular), the

atter structures. are sensitive to

of this study wase mouse model.in this study. In ne) oxaldihydrazmal diet for 10 wr DKI acquisition234×234 μm2, 4

py (FA), mean (Mta set14 using antric maps were mC), middle (bCC)nih.gov/ij/). Two-s statistically sig

mages, MK mapshrome was perfobrain regions. Cnd increased MDwed significantlychanges are qua(10 weeks of creased in the pC, but it was sigle and more promhe exact interpre

n only be done wian diffusion meCPZ mice, wh

confirming that ry we observed, gnificant advant

metrics for ) mice. Brain

middle (bCC), hippocampus

05. Error bars

on in the Cuprncois3, Xingju NieMedical Physics, Nangeburg, New Yo

el of demyelinatbis-cyclohexanonound in the corp

demyelination hHowever, no coruantifies the non-n is believed to ae measures of D

Indeed, severachanges in brain

s to quantitatively the cuprizone (Czone, Sigma-Ald

weeks. All in vivo n. The sequence4 averages, 30

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gnificant. s and the ormed to onsistent D and λ┴ y reduced alitatively cuprizone CC when gnificantly minent in etation of

with future etrics MK, ich likely kurtosis metricsfor the first time

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Fig.1(Solo

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tion1. Reproducibne oxaldihydrazo

pus callosum (CChas also been obrtical diffusion M-Gaussian behavarise from the p

DKI can be consial animal studiesn microstructuray characterize th

CPZ) treated grodrich) for a periMRI experiment

e parameters wegradient directio

nd radial (λ┴) diffare programmed5 µm2/ms) to reCC), cortex (CTas performed to

s are sensitive ine, non-Gaussian uctural characte

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LEDGMENTS: T9711-2 (MFF) an

1. b0 images, ochrome) of control

Model li Tabesh1, and Maitute, Orangeburg,ates

ble CNS demyeone). After remoC), with oligodenbserved5. Previo

MRI changes havvior of water diffuresence of diffusidered natural ins have shown thl complexity ass

he diffusional kur

up (n=12) mice wiod of 10 weeksts were performe

ere: TR/TE=3000ons19 and five bfusivity, as well ad in Matlab (The duce partial volu), hippocampus

o assess differe

ndicators of chadiffusion changerization using D

dsen O, et al. (2. Ludwin SK. (1ima GK & MoreMcMahon EJ,

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gn Reson Med, 6

This study was snd 1S10RR02353

MK maps, and l and cuprizone tre

aria F Falangola1,2

, New York, NY,

lination will resuoval of the toxinndrocyte damagous diffusion MRve been reportedusion, contributinsion barriers (ce

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were fed a diet os to induce CNed on a 7T Agilen0/30 ms, δ/∆=5/1b-values for eacas, mean kurtosMathWorks, Inc

ume effects. Braidorsal (dHP) an

ences in the RO

nges in structuraes in the cortex o

DKI, especially fo

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Cheung MM, et aheung MM, et a:3328. 19. Jone42(3):515-525.2065(3):823-36.

supported by NI34-01.

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3066Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)