Definiens Tissue Studio Advanced Digital Pathology Image Analysis Solution

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The Most Advanced Digital Pathology Image Analysis Solution

Definiens Tissue Studio™

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Definiens Tissue Studio™ overview

Enables simple, fast, and accurate ROI detection via the new Definiens Composer Technology™

Provides multi-parametric quantitation on a cell-by-cell basis

Handles heterogeneous tissue samples

Works with whole slides and TMAs

Handles images acquired from any source

Operates as a dedicated workstation or as a client server application

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Definiens Composer Technology™

What is it?

Definiens Composer Technology™ was developed to enable the user to easily teach the system how to identify regions of interest (ROIs).

How does it work?

Simply load up to 4 representative images, and use the “paintbrush tool” on a few representative ROIs in your images. Then click the “Learn” button.

How does this differ from other approaches?

Training the system with 4 representative images ensures a robust image analysis solution without over fitting.

Combines machine learning, pattern recognition and auto adaptive analysis algorithms based on Definiens eCognition Network Language ™.

Definiens Tissue Studio™ is faster and more flexible.

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ROI Detection and Cell by Cell Analysis across and within selected ROIs

Definiens Tissue Studio™ Workflow

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Load training images

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Define image analysis solution

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Load up to four different images:Detect tissue / Background / Segment images

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Definiens Composer Technology™:“Paint” on a few representative ROIs

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Definiens Composer Technology™:After painting a few ROIs, click the “Learn” button

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Definiens Composer Technology™:Computer has now been “trained”

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Definiens Composer Technology™:Merge “Object Primitives”

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Second Definiens Composer step:Re-classify Islets into “tumor” and “normal”

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Select ROIs in tumor islets

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ROIs at 20xParameters can be adjusted and previewed here

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Detect nuclei

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Batch Process:Analyze selected images

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Export multi-parametric quantitative features

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List of supported instruments

Hamamatsu: Nanozoomer

Zeiss: Mirax

Aperio: Scanscope

Applied Imaging: Ariol

TissueGnostics

Bacus WebSlide

DMetrix

Generic (tif, jpg, etc.)

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Summary

Deeper insights

Quantifies nuclear, membrane and cytoplasmic biomarkers on a cell-by-cell basis

Supports all standard IHC tissue stains (blue, brown and red), H&E and IF

Analyzes all slides and TMA images from all major image acquisition devices  

Faster results

Identifies regions of interest automatically

Operates through a simple, intuitive user interface

Offers unlimited throughput with parallel batch processing 

Better decisions

Delivers accurate and reproducible results

Enables multiparametric investigations to identify underlying correlations

Supports translational research through rapid iterative investigation of biomarkers

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Daniel R. Nicolson

Director, Global Accounts

484-678-9090

dnicolson@definiens.com

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