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Current Thoughts About Laparoscopic Fundoplication in
Infants and Children
George W. Holcomb, III, M.D., MBA
Surgeon-in-ChiefChildren’s Mercy Hospital
Kansas City, Missouri
Gastroesophageal Reflux
GER – presence of gastroesophageal reflux
GERD – symptomatic gastroesophageal reflux
• Wt loss/FTT
• ALTE
• Pulmonary Sxs., RAD
• Esophagitis: pain, stricture, Barrett’s
GERDBarriers to Mucosal Injury
• Lower esophageal sphincter (LES)
• Esophageal IAL
• Angle of His
• Esophageal motility
Preoperative Evaluation• 24 hr pH study – gold standard in many centers
Only measures acid reflux
• Impedance – acid & alkaline reflux
• Upper GI contrast study -reflux seen in only 30%
• Endoscopy - visualization only not sensitive
• Endoscopy with biopsy – probably most sensitive
• Gastric emptying study ? – not performed at initial operation
• Esophageal motility study - not needed in children?
Children’s Mercy Hospital(Jan 2000 – June 2007)
843 fundoplications( 3.6% op. vol.)
UGI – 656 pts
pH study – 379 pts
Sensitivity UGI – 30.8%AAP, 2009AAP, 2009
J Pediatr Surg 45:1169-1172, 2010J Pediatr Surg 45:1169-1172, 2010
Children’s Mercy HospitalUGI – 656 pts
Abnormality (other than GER) – 30 pts (4.5%)
Suspected malrotation – 26 pts (4.0%)
Confirmed (16 pts) No malrotation (6 pts) Prev. Ladd (4 pts)
AAP, 2009AAP, 2009
J Pediatr Surg 45:1169-1172, 2010J Pediatr Surg 45:1169-1172, 2010
Children’s Mercy Hospital
Preoperative UGI – 656 pts
Influences management - 4%
Malrotation is the most common finding
AAP, 2009AAP, 2009
J Pediatr Surg 45:1169-1172,J Pediatr Surg 45:1169-1172, 20102010
GERDFundoplication
Indications for operation (U.S.)
Failure of medical therapy
ALTE/weight loss in infants
Refractory pulmonary symptoms
Neurologically impaired child who needs gastrostomy
Options for Fundoplication
• Laparoscopic vs open
• Complete (Nissen) vs Partial (Thal,
Boix-Ochoa, Toupet)
1) Effects of Pneumoperitoneum
• SVR
• PVR
• SV
• CI
• Venous Return (Head up)
• pCO2
• FRC
• pH
• pO2
Proceed With Caution VSD with reactive pulmonary HTN
CAVC – ( PVR 2o to pCO2, pO2, pH) Neonates (in general) with reactive or persistent P-
HTN Palliated defects with passive pulmonary blood flow
(Glenn, Fontan procedures) – Risk is pulmonary flow, reversal of flow thru shunt and clotting of shunt
Any defect adversely affected by SVR• HLHS• CHF (unrepaired septal defects: VSD, CAVC)
• Risk is acute CHF 2o to afterload & shunting, unbalancing the defect
Laparoscopic Fundoplication
2) Is dysphagia a common problem
following laparoscopic Nissen
fundoplication in infants and
children?
Intraoperative Bougie Sizes
PAPS, 2002PAPS, 2002
J Pediatr Surg 37:1664-1666, 2002J Pediatr Surg 37:1664-1666, 2002
Laparoscopic Fundoplication
3) Can stab (3mm) incisions be used
rather than cannulas for
laparoscopic operations?
The Use of Stab Incisions2000-2002
Procedure (n) Used/case Saved/case Nissen (209) 1 4
Nissen (14) 2 3
Heller Myotomy (7) 2 3
Appendectomy (102) 2 1
Meckel’s Diverticulum (2) 2 1
Pyloromyotomy (77) 1 2
Cholecystectomy (31) 2 2
Pullthrough (20) 2 1
Splenectomy (21) 2 2
Adrenalectomy (6) 2 2
UDT (15) 1 2
Varicocele (5) 1 2
Ovarian (2) 1 2
Totals (511) 714 1337 PAPS, 2003PAPS, 2003
JPS 38:1837-1840, 2003JPS 38:1837-1840, 2003
Laparoscopic Fundoplication
4) Is there a financial advantage with the
laparoscopic approach when compared
to the open operation?
Clinical and Financial Analysis of Pediatric Laparoscopic versus Open Fundoplication
100 Patients
Favoring LF P Value Favoring OF P Value
LOS (1.2 vs 2.9 days) <0.01 Op Time (77 vs 91 min) 0.03
Initial Feeds (7.3 vs 27.9 hrs)
Full Feeds (21.8 vs 42.9 hrs)
<0.01
<0.01
Hospital Room ($1290 vs $2847)
Pharmacy ($180 vs $461)
Equipment ($1006 vs $1609)
0.004
0.01
0.003
Anesthesia ($389 vs $475)
Operating Suite ($4058 vs $5142)
Central Supply/Sterilization ($1367 vs $2515)
0.01
0.04
<0.001
Total Charges Similar (LF - $11,449 OF - $11,632)
IPEG 2006IPEG 2006J Lap Endosc Surg Tech 17:493-496,2007J Lap Endosc Surg Tech 17:493-496,2007
Laparoscopic Fundoplication5) Should the esophagus be extensively mobilized?
Technique 2000 - 2002Please use this link if you experience problems viewing the video above.
Current ThoughtsTechnique 2003 - 2010
1. Less mobilization of esophagus
2. Keep peritoneal barrier b/w esophagus & crura
Laparoscopic FundoplicationCurrent Technique - 2010
Please use this link if you experience problems viewing the video above.
Personal Series - CMHJan 2000 – March 2002
Group I - 130 PtsNo Esophagus – Crural Sutures
Extensive Esophageal Mobilization
Mean age/weight 21 mo/10 kg
Mean operative time 93 minutes
Transmigration wrap 15 (12%)
Postoperative dilation 0
APSA, 2006 APSA, 2006 J Pediatr Surg 42:25-30, 2007J Pediatr Surg 42:25-30, 2007
Personal Series - CMHApril 2002 – December 2004
Group II - 119 PtsEsophagus – Crural Sutures
Minimal Esophageal Mobilization
Mean age/weight 27 mo/11 kg
Mean operative time 102 minutes
Transmigration wrap 6 (5%)
Postoperative dilation 1
APSA, 2006 APSA, 2006 J Pediatr Surg 42:25-30, 2007J Pediatr Surg 42:25-30, 2007
The relative risk of wrap transmigration
in patients without esophago-crural
sutures and with extensive esophageal
mobilization was 2.29 times the risk if
these sutures were utilized and if minimal
esophageal dissection was performed.
Summary
Group II119 Patients
Esophago-Crural Sutures
# Patients Transmigration %
2 silk sutures 20 5 25%(9, 3 o’clock)
3 silk sutures 43 1 2.3%(9, 12, 3 o’clock)
4 silk sutures 56 0 0%(8, 11, 1, 4 o’clock)
Patients Less Than 60 MonthsGroup I
Jan 00-March 02
117 Pts
Group II
April 02-Dec 04
102 Pts
P Value
Mean Age (mos) 10.26 10.95 0.650
Mean Wt (kg) 7.03 7.17 0.801
Gastrostomy 47% 46% 0.893
Neuro Impaired 71% 61% 0.118
Wrap Transmigration
14 (12%) 6 (6%) 0.159
The relative risk of transmigration of the wrap is 2.03 times greater for Group I than for Group II
APSA, 2006 APSA, 2006 J Pediatr Surg 42:25-30, 2007J Pediatr Surg 42:25-30, 2007
Patients Less Than 24 MonthsGroup I
Jan 00-March 02
104 Pts
Group IIApril 02-Dec 04
93 PtsP Value
Mean Age (mos) 6.99 8.15 0.175
Mean Wt (kg) 6.32 6.46 0.759
Gastrostomy 46% 46% 0.999
Neuro Impairment
73% 60% 0.069
Wrap Transmigration 13 (12%) 6 (6%) .226
The relative risk of transmigration of the wrap is 1.94 times greater for Group I than for Group II
APSA, 2006 APSA, 2006 J Pediatr Surg 42:25-30, 2007J Pediatr Surg 42:25-30, 2007
Prospective, Randomized Trial• 2 Institutions: CMH, CH-Alabama
• Power analysis using retrospective data (12% vs 5%) : 360 patients
• Primary endpoint -- transmigration rate
• 2 groups: minimal vs. extensive esophageal dissection
• Both groups received esophago-crural sutures
• Stratified for neurological status
• UGI contrast study one year post-op
• APSA, 2010
Minimal vs Extensive Esophageal Mobilization During Laparoscopic
Fundoplication
Extensive Esophageal Mobilization (N=87)
Minimal Esophageal Mobilization (N=90)
P-Value
Age (yrs) 1.9 +/- 3.3 2.5 +/- 3.5 0.30
Weight (kg) 10.7 +- 11.9 12.6 +/- 18.2 0.44
Neurologically Impaired (%)
51.7 54.4 0.76
Operating Time (Minutes)
100 +/- 34 95 +/- 37 0.37
APSA, 2010APSA, 2010J Pediatr Surg 43:163-169, J Pediatr Surg 43:163-169,
20112011
Preoperative Demographics177 Patients
Minimal vs Extensive Esophageal Mobilization During Laparoscopic
Fundoplication
Extensive Esophageal Mobilization (N=87)
Minimal Esophageal Mobilization (N=90)
P-Value
Postoperative Wrap Transmigration (%) 30.0% 7.8% 0.002
Need for Re-do Fundoplication (%) 18.4% 3.3% 0.006
APSA, 2010APSA, 2010J Pediatr Surg 43:163-169, 2011J Pediatr Surg 43:163-169, 2011
Results177 Patients
Current Study
• Analysis (80% power,α- 0.05) – 110 patients
• Minimal esophageal dissection in all patients
• 4 esophago-crural sutures vs. no sutures
No Esophago-crural Sutures
Please use this link if you experience problems viewing the video above.
Study # Pts % Re-op Herniation Wrap Dehiscence
Other
Wheatley (Michigan) 1974-1989
242 12%
(29)
3 14 3
Caniano (Ohio State) 1976 - 1988
358 6%
(21)
16 2 3
Dedinsky (Indiana) 1975-1985
429 6.7%
(29)
29
Fonkalsrud (UCLA)
1976-1996
7467 7.1%
Operative ResultsOpen Operations
Re-Do Fundoplication (Personal Series)
• Jan 00 – March 02
15/130 Pts – 12%
• April 02 – December 06
7/184 Pts – 3.8%
J Pediatr Surg 42:1298-1301, 2007J Pediatr Surg 42:1298-1301, 2007
Re-Do Fundoplication (Personal Series)
22 Pts (2000 – 2006)
• All but one had transmigration of wrap
• Mean age initial operation – 12.6 (±5.8) mos
• 11 had gastrostomy
• Mean time b/w initial operation & 1st redo – 14.1 (±1.7) mos
• F/U – Minimum -19 mos
Mean - 34 mos
J Pediatr Surg 42:1298-1301, 2007J Pediatr Surg 42:1298-1301, 2007
SIS and Paraesophageal Hernia Repair
• Multicenter, prospective randomized trial
• 108 patients
• Recurrence: 7% vs 25% (1o repair)
• No mesh related complications
Oelschlager BK, et alOelschlager BK, et alAnn Surg 244:481-490, 2006 Ann Surg 244:481-490, 2006
ASA Meeting, 2006ASA Meeting, 2006
QUESTIONS
www.cmhmis.com
www.cmhclinicaltrials.com
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