Creating sustainable resources through interdisciplinary ... · Kazuo Shinozaki Kazuki Saito...

Creatingsustainableresourcesthrough

interdisciplinaryresearchbasedonbiologyandchemistry

RIKENCenterforSustainableResourceScience(CSRS)Since2013

CenterDirectorKazuoShinozaki　　　　　　

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RIKENEuropeOfficeAnniversarySymposiumShapingfuturesocietywithcutting-edgeSTI

December2,2019

Ocean and soil pollution,desertification

Global Warming,Climate change

-  Contribution to SDGs -  Breeding of crops and biomass-  Sustainable production of materials-  Carbon capture and utilization

Importance of science and technology for sustainable

development of society.

Increasing Global Populations

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Science and technology contribute to solve global problems.

2ReportofIPCCOctober6,2018

Desertification

TheSustainableDevelopmentGoals(SDGs),UN2015.9

COP21TheParisAgreement2015.11

GenomeTechnologies-  Genomesequencetechnology-  Genomeeditingtechnology-  SyntheticGenomics

DataScienceandArtificialIntelligence-  DataScience-  ArtificialIntelligence-  Bioinformatics,MaterialInformatics,

ParadigmShiftinSocialNeedsandTechnologies

Society5.0fortheadvancementofsmartsociety　 (5thScienceandTechnologyBasicPlan,JapanCabinetOffice,2016-2020)-RIKENstartedAIPcenter(AIanddatascience)in2015

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IntroductionofRIKENCSRSProjects

DirectorKazuoShinozaki

KazukiSaito

●Startedin2013bythereorganizationofPlantScienceCenter,ChemicalBiology,andCatalyticChemistryProgramsforthecontributiontoasustainableproductionbasedonbiologyandchemistry.BiomassEngineeringProgramjoinedCSRSin2015.●Started5flagshipprojectsin2018forthecontributiontoSustainableDevelopmentGoals(SDGs) andSociety5.0.

DeputyDirectors

HiroyukiOsada ZaominHou MinamiMatsui

CreationandEfficientusageofnaturalresourcesforsustainabledevelopmentofhumankind �

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•  5 flagship projects contributing to “Sustainable Development Goals (SDGs)” are promoted to incorporate plant biology, biotechnology, chemical biology, and chemistry.

•  Based on results of first phase, R&D on problem-solving is based on sustainable production of useful materials and biomass.

•  Establish various types of collaboration

Contributing to sustainable food and biomass production through development of plant trait improvement techniques

Maximizing capacities of plants and microorganisms for chemical synthesis in expanding the production and use of bioproducts

Developing new, highly efficient catalysts that use natural resources

Developing new polymers with beneficial functions improving efficiency in the use of resources and creating new industries

Advancing analytical technology and information platforms and leading innovation as a science and technology hub in Japan

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5FlagshipProjectsin4thMidtermPlan

5FlagshipProjectsin4thMidtermPlan

CSRSorganization3Locations:Yokohamacampus,Wakocampus,TsukubacampusMembers:31PIs,150researchers+postdocs,100technicalstaffsCenterBudgets:1,820millionyen(15,6millionEUR)

Contributing to sustainable food and biomass production through development of plant trait improvement techniques 10 Labs

Maximizing capacities of plants and microorganisms for chemical synthesis in expanding the production and use of bioproducts 5 Labs

Developing new, highly efficient catalysts that use natural resources 5 Labs

Developing new polymers with beneficial functions improving efficiency in the use of resources and creating new industries 3 Labs

Advancing analytical technology and information platforms and leading innovation as a science and technology hub in Japan 12 Labs

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TechnologyPlatformDivisionMolecularStructureCharacterizationUnit BiomolecularCharacterizationUnit

MassSpectrometryandMicroscopyUnit

• MassSpectrography(MS)andNMRplatformforanalyzingplantmetabolomesandhormones

MassspectroscopeandNMRdeviceforanalyzingmetabolomes/hormones

Microscopesforanalysisoftissuesandcells

ChemicalBiologyResearchGroup

PlatformforChemicallibrariesandchemicalscreening

Explorationofchemicalsusingchemicalarrays

MetabolomicsResearchGroup

Databaseformetabolites（NPPlot）

KazukiSaitoDeputyDirector

HiroyukiOsadaDeputyDirector

Natural compound library (NPDepo)

AdvancedResearchandTechnologyPlatforms

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PromotesnewmethodsandtechnologicaldevelopmentrelatedtoNMRandMSnecessaryfordeterminationofstructure

Promotesappliedresearchondevelopingmethodstoanalyzethestructureofbiologicalcomponentsandstructuralanalysis

Isoprene bio-production by designing an artificial metabolic pathwayKondogroupsucceededinconstructinganartificialmetabolicpathwaysynthesizingisopreneefficientlyinE.coli,andcollaboratedwitharubbercompanyforapplication.

ResearchAchievements　1

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Plant-derived biodegraded polymer AbegrouphascollaboratedwithKanekacompanytodevelopbiodegradedpolymerPHAandPHB.Recently,thePHBbiopolymerisrecognizedasusefulbiodegradedplasticsthatcansolvemicro-plasticpollutioninocean.

New type of self-healing material Hougroupsucceededincreatingnewfunctionalpolymerswithcharacteristicsofself-healingandshapememoryundertheconditionsinnotonlydryairbutalsowater,andacidicandalkalineaqueoussolutions.Thisresearchwasveryuniqueandvisibletoattractmanycompanies.(JACS2019)

SaitogroupsucceededtoreduceSGAcontentbysuppressinggenesthatareexpressedinshootsandflowers.Theyieldofpotatodoesnotchange,andstoringwithoutsprouting.(PlantCell2014,PlantPhys.2016)

Developmentofpoisonlesspotatoes,thatcanbestoredforalongtime

NewlydiscoveredpeptidehormonehelpskeepplantsfromdehydrationShinozakigroupdiscoveredCLE25peptideregulatingdehydrationstressresistanceviaroot-to-shootlongdistancesignaling.Thisdiscoverywasuniqueandvisibleinplantscience.　(Nature2018) Drought CLE25

CLE25

ABA

Stomata Close

Stress genes

ResearchAchievements　2BreedingdroughttolerantuplandriceGMcultivarsandtheirfieldtestTheGolS2transgenicriceplantsaredroughttolerantandmaintainahighcropyieldunderdryfieldofCIATinColumbia　(PlantBiotechJ2017)

Non-transgenicrice IntroducedAtGolS2rice

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Lam-SonPhanTran

2018JapanMedicalResearchandDevelopmentGrandPrize

ChemicalBiologyFunctionalgenomics

M.Yoshida

PlantScienceandBiochemistryarevisibleresearchareainRIKEN

Source:ScienceMap2014,NISTEPREPORTNo.169,September,2016.MEXTNISTEPcreatedandprocessedbyRIKEN.

PlantscienceBiomass

Catalystchemistry

Chemicalbiology

9researchersfromCSRS（6PIs,and3others）selectedas“HighlyCitedResearchers2018*”byClarivateAnalytics(formerlyThomsonReuters）(*Authorswhosepublicationswerequotedinthetop1%from2006to2016)

KazuoShinozaki KazukiSaito

MotoakiSeki MitsunoriSeo

KenShirasu

※ClarivateAnalyticsselected90researchersfromJapan,of20researcherswereselectedin4fieldsfromRIKEN.

2016PersonofCulturalMerit/MedalwithPurpleRibbon

K.Shinozaki

Plantstressbiology,Functionalgenomics

2018MedalwithPurpleRibbon

K.Saito

PlantMetabolomicsMetabolicengineering

2015InhoffenMedalFirstJapanesetoreceivetheaward

H.Osada

ChemicalBiology,Drugdiscovery

High-levelresearch:Plantscienceandchemicalbiology

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Project Management in CSRS

CSRSCoreresearch

Platform

RIKENProjects

CSRSProjects

University,Inter-MinistryCollaboration

International,Industrial

Collaboration

Varioustypesofcollaborationareimportantforthesegoals �

Microbial–hostsymbioticSystem,iSYM(2017-)DrugDiscoveryPlatform(2010– )

AIST,NARO,FFPRI,FRA

NagoyaUniv.YokohamaCityUniv.KeioUniv.

MaxPlanckInst.(Germany)VIB-PSB(Gent,Belgium)JohnInnesInstitute(UK) INRA(Paris,France)MichiganStateU.(US)UniversityofToronto(Canada)

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InternationalcollaborationsinCSRS

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⑩

⑤

A

B

C

H

E F

G

InternationalCollaborationisimportantforinnovation.

D

J

I

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(Joint papers/1311 papers, 2015-2018)

K

◉ Max Planck Institute of Molecular Plant Physiology, Germany (32) ◉ Max Planck Institute of Systems Chemical Biology, Germany

◉ The Sainsbury Laboratory, UK (11)

◉ Umea Plant Science Center, Sweden

◉ Michigan State University, USA

◉ University of Toronto, Canada (12)

◉ Universiti Sains Malaysia, Malaysia ◉ Agricultural Genetics Institute, Viet Nam

◉ International Center for Tropical Agriculture, Columbia

◉ INRA, France

F

F

◉ VIB-Plant Systems Biology, Belgium

CollaborationswithinstitutesinEUcountries

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- Chemical Biology ◉ Max Planck Institute of Systems Chemical Biology, Germany - Plant Metabolomics ◉ Max Planck Institute of Molecular Plant Physiology, Germany ◉ Umea Plant Science Center, Sweden - Plant Biology ◉ John Innes Centre and the Sainsbury Laboratory, UK - Plant hormone Research ◉ INRA, France - Plant Biology ◉ VIB-Plant Systems Biology, Gent, Belgium

-WehavebeencollaboratingwithInstitutesinEUcountriesmainlyinplantbiologyandchemicalbiology.-WeareplanningtopromotecollaborationwithVIB,Belgium.

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Thank you for your attention.

We are planning to promote various types of collaboration with Institutes in EU countries for the contribution to SDGs.

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