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Commonly Used EPA Registered Canine Topical Flea and Tick Control Products
External parasites pose a threat to your patients year round, so clients deserve your very best advice when developing a strategy for controlling infestations. This chart represents the most commonly used EPA-regulated canine topical flea & tick control products as of April 1, 2016. All products are applied monthly unless otherwise indicated. Please refer to individual product labels and package information for more details on target parasites, contraindications, and safety information. Products listed here are not for use on cats.
*Refer to product label for specific tick, mosquito, fly, and mite species affected.† Indicates that the product repels the selected parasite.
The trademarks and trade names listed above are the property of their respective owners. This poster is an independent publication and has not been authorized, sponsored, or otherwise approved by any of the companies who own the products listed.
Jorge Guerrero,DiplEVPC (ret),DVM, MSc, PhD,is an internation-ally recognizedveterinary para-sitologist, with aunique blend ofexperience in the animal health in-dustry and academia. He has beenAdjunct Professor of Parasitologyat the University of Pennsylvaniasince 1983. Dr. Guerrero is PastPresident of the North AmericanVeterinary Conference (NAVC) anda recipient of the DistinguishedVeterinary Parasitologists Awardfor 2005, granted by the AmericanAssociation of Veterinary Parasitolo-gists. Dr. Guerrero has authoredor co-authored more than 170refereed original research articlesand book chapters, and in 2010 heco-authored a book on helminthparasite infections of dogs and cats.
Activyl® Merck 773-94 X X - - - - - - 8 weeks 19.53% Indoxacarb
Activyl® Tick Plus Merck 773-95 X X X - - - - - 8 weeks 13.01% Indoxacarb + 42.5% Permethrin
Adams™ Spot-On® Farnam 2724-811270 X X X - - X - - 6 months 30% Etofenprox 5% PBO 3.6% (S)-Methoprene
Advantage® II Bayer 11556-125 (127,128,130) X X - - - - X - 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen
Advecta™ II CapInnoVet 2596-180-91384 X X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen
Adventure™ Plus Promika 91300-2 X X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen
Barricade™ Spot On® Farnam 88052-8-89459 X - X - - - X - 8 weeks 9.7% Fipronil
Bio Spot® Spot On® Farnam 2724-497-270 X X X - - X - - 6 months 45% Permethrin 3% (S)-Methoprene
Bio Spot® Defense™ Farnam 2724-796-270 X X X - - X - - 6 months 30% Etofenprox 5% PBO 3.6% (S)-Methoprene
Certifect® Merial 65331-7 X X X X X - X - 8 weeks 9.8% Fipronil + 22.1% Amitraz 8.8% (S)-Methoprene
Defense Care™ Bayer 1156-135 X - X - - X X X 7 weeks 8.8% Imidacloprid + 44% Permethrin
Effitix® Virbac 2382-187 X - X X - X X X 12 week 6.01% Fipronil + 44.8% Permethrin
Flea 5X Plus™ 1800 PetMeds 2517-134-88832 X X X - - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene
Fortress™ Spot On® Farnam 88052-8-89459 X - X - - - X - 8 weeks 9.7% Fipronil
Frontline® Gold Merial 2596-178-65331 X X X X 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene + 0.25% Pyriproxyfen
Frontline® TriTak® Merial 2517-142-65331 X X X X - - X - 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin 8.8% (S)-Methoprene
Frontline® Plus Merial 65331-5 X X X - - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene
Happy Jack® DuraSpot™ Happy Jack Inc. 67505-3-2781 X X X X X X 12 weeks 45% Permethrin 5.0% Pyriproxyfen
Hartz® UltraGuard® Hartz 2596-167 X - X - X X - - 12 weeks 55% Etofenprox 10% PBO + 1% MGK-264
Hartz® UltraGuard Plus® Hartz 2596-168 X X X - X X - - 12 weeks 55% Etofenprox 10% PBO + 1% MGK-264 0.5% Pyriproxyfen
Hartz® UltraGuard Pro® Hartz 2596-169 X X X - X X - - 12 weeks 55% Etofenprox 10% PBO + 1% MGK-264 0.5% Pyriproxyfen + 0.25% (S)-Methoprene
Hartz First Defense® Hartz 2596-163 X - X - - - X - 8 weeks 9.7% Fipronil
K9 Advantix® Bayer 11556-132 (133,134,135) X - X - - X X X 7 weeks 8.8% Imidacloprid + 44% Permethrin
K9 Advantix® II Bayer 11556-141 (142,143,144) X X X - - X X X 7 weeks 8.8% Imidacloprid + 44% Permethrin 0.44% Pyriproxyfen
Liberty® 50 Plus IGR Spot-On Star Horse Products 75844-8-81021 X X X X - X X - 12 weeks 50% Permethrin 1.2% Pyriproxyfen
Para / Defense™ CapInnoVet 2596-180-91384 X X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen
ParaStar® Novartis 70585-12 X - X - - - X - 8 weeks 9.7% Fipronil
ParaStar® Plus Novartis 70585-13 X - X X - - X - 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin
PetAction™ Plus TruRX, LLC 91019-1 X X X X - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene
Pet Armor® Perrigo 86230-2-85495 X - X - - - X - 8 weeks 9.7% Fipronil
Pet Armor® Advanced 2 Perrigo 2517-176 X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen
Pet Armor® Plus Perrigo 2517-134 X X X - - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene
PetLock™ Plus TruRX, LLC 88052-13-89609 X X X X X - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene
Pet Lock™ II CapInnoVet 2596-180-91384 X X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen
Sentry® FiproGuard® Perrigo 2517-136 X - X - - - X - 8 weeks 9.7% Fipronil
Sentry® FiproGuard® Max Perrigo 2517-140 X - X - - - X - 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin
Sentry® FiproGuard® Plus Perrigo 2517-134 X X X - - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene
Sentry® Pro Squeeze-On Perrigo 2517-87 X X X - - X - - 12 weeks 45% Permethrin 1.9% Pyriproxyfen
Sentry® Pro XFT Large Dog Perrigo 2517-130 X X X - - X - - 12 weeks 30% Cyphenothrin 2% Pyriproxyfen
Sentry Pro® XFT Small/Medium Dog Perrigo 2517-129 X X X - - X - - 12 weeks 20% Cyphenothrin 2% Pyriproxyfen
Sentry Pro® Toy Dog Perrigo 2517-133 X X X - - X - - 12 weeks 55% Etofenprox 2.2% Pyriproxyfen
Sergeant's® Pronyl OTC™ Perrigo 2517-136 X - X - - - X - 8 weeks 9.7% Fipronil
Sergeant's® Pronyl OTC™ Max Perrigo 2517-140 X - X - - - X - 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin
Sergeant's® Squeeze-On Perrigo 2517-126 X X X - - X - - 12 weeks 45% Permethrin 1.2% (S)-Methoprene
ShieldTec™ Plus Promika 91300-1 X X X X X X 12 weeks 45% Permethrin 5.0% Pyriproxyfen
SpectraSure® Plus IGR Durvet 53883-351-89400 X - X - - - X - 12 weeks 9.8% Fipronil 8.8% (S)-Methoprene
TripleGuard™ PetBalance 67505-3-88966 X T X XT - - X X - 12 weeks 45% Permethrin 5% Pyriproxyfen
Vectra® Ceva 83399-10 X X - - - - - - 8 weeks 22% Dinotefuran 3% Pyriproxyfen
Vectra 3D® Ceva 83399-6 X X X - - X X X 7 weeks 4.95% Dinotefuran + 36.08% Permethrin 0.44% Pyriproxyfen
Vet Guard® Plus Pet IQ 67505-3-88966l X X X - - X X - 12 weeks 45% Permethrin 5% Pyriproxyfen
Zodiac® Spot On® Farnam 2724-497 X X X - - X - - 6 months 45% Permethrin 3% (S)-Methoprene
ZoGuard™ Plus Promika 53883-351-91300 X X X X 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene
Updated: April, 2016.Information presented is believed to be accurate, but not guaranteed.
Canine P
roducts
Man
ufactu
rer
EPA Reg
Number
Earli
est A
ge for U
se
Killing In
gredien
ts
Syner
gist In
gredien
ts
Insect
Growth
Regulat
ors (IG
Rs)
(Only
Control
Pre-a
dult Fle
as)
Kills A
dult Fle
as
Kills Pr
e-adult
Fleas
(Eggs/L
arva
e)
Kills Ti
cks*
Controls
Mite
s*
Kills Ti
ck N
ymphs &
Larv
ae
Kills/R
epels
Mosq
uitoes
*
Kills Li
ce
Kills Fl
ies*
Active Ingredients
† †
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