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Class I
Class II
Class III
NH2 COOH
N
1 2 3 4 5 7 8 6 12 11 10 9
Extracellular
Intracellular
LL LL
QLS
pm
ol/
oo
cyte
/min
0
10
20
30
40
50
60
70
NI
GLUT12
Na+ buffer Na
+- free
ree
buffer
A. Glucose 100 mM B. Glucose 100 mM
Related diseases
• Obesity ? • Type II diabetes? • Cancer Physiological
role
Breast and Prostate Cancer
Location
Physiological role
Adipose Tissue
Skeletal Muscle
Small intestine
Unknown
• Glucose • Galactose • Fructose
Glucose SLC2A12/ GLUT12 Functional characteristics
Equilibrative Concentrative
Glucose H+
or Na+ ?
or
Extracellular
Intracellular Substrates
Cytoplasmic Vesicles Translocation
IRS-1
PI3K PDKI
GLUT4
GLUT12
Insulin response Glucose Insulin
IR GLUT12 GLUT4
Glucose Glycolytic metabolism
Mitochondrion
Pyruvate
Lactate
GLUT1 GLUT12 MCT1
LDH-A Glycolysis
H+
Oxidative metabolism
Glucose
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