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circulation
KIDNEYS
ureters
bladder
Glomerulus (plasma filtration)
Tubule (reabsorption)
urethra
URINARY-PROTEOMEto the ureter30% circulation
70% urogenital tract
Figure 1
primitive urine
= reabsorption
NEPHRON
final urine
Figure 2
Ureteropelvic junction (UPJ) obstruction
Spontaneousresolution
Relief surgery (pyeloplasty)
?Intermediateobstruction
Spontaneous resolution
pyeloplasty
birth 1 to 2 years
scintigraphies
A
B
–1
–0.5
0
0.5
1
Mem
bers
hip
9 months
spontaneous resolution
surgery
Clin
ical
ev
olu
tio
n
15 months
Pre
dic
tio
n b
ased
on
u
rin
ary
pro
teo
mic
s
Figure 3
LARGE DYNAMIC
RANGELigand peptide library
(millions of different ligands)
Flow-Through:Highly abundant proteins
REDUCEDDYNAMICRANGE
+
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