Chromeleon 7 Operational Simplicity for the...

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Chromeleon 7 Operational Simplicity for the Laboratory

• Introducing Chromeleon 7 • User Interface • Peak Detection Tools • eWorkflows™ • Interactive Charting • Reporting • Support for Third Party Instrumentation • Summary

Topics

Introducing Chromeleon® 7

• New-generation Chromatography Data System

• “Simply Intelligent”

• Intelligent Functionality - it does everything you need!

• Operational Simplicity™ - everything is fast and easy!

• Simplifies all chromatography processes

Chromeleon® 7 - Operational Simplicity

• Operational Simplicity™ was the core design principle

• Major design rules:

• Minimize number of steps needed to perform any task

• Make all steps easy to understand and easy to use

• Minimize time needed to perform any task

• Major features for Operational Simplicity:

• Modern user interface

• Peak detection and integration tools

• eWorkflows

• Data visualization tools

• Enterprise functionality

USER INTERFACE

User Interface

The Chromeleon User Interface consists of two major parts: • Chromeleon Console • Chromatography Studio

Chromeleon Console

• Designed to provide easy navigation through your data

• Provides quick access to:

• Instruments • Data • eWorkflows

Console – Quick Access to Information

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Navigation Pane

Category Bars

Thumbnails – Quick Access to Data

• Quick check to see if chromatogram ran properly

• Check for presence / absence of peaks

• Check quality of separations

Instruments - ePanels

Provides access to all instruments on the network

Direct Control of Instrument through controls on ePanel

Chromatography Studio

• Used for All Data Evaluation • Provides access to every object in the sequence:

• Injection List • Instrument Method • Processing Method • Results • Report Template • Spectral Library

• Opens in separate window on task bar – makes working with multiple sequences easy

• Uses new “Ribbon” technology introduced in Microsoft Office 2007

Chromatography Studio

Category Bars

Navigation Pane

Ribbon

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New Ribbon Interface

• Provides contextual access to commands and options in the Studio

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PEAK DETECTION COBRA™ Detection Algorithm / SmartPeaks™

Peak Detection

• Most time consuming and tedious task in chromatography process:

• Chromatogram Integration

• Chromeleon 7 introduces two new tools to simplify this process:

• Cobra Peak Detection Algorithm / Wizard

• SmartPeaks Integration Assistant

Peak Detection – Cobra

• Cobra is a new algorithm that:

• Finds peak start and end times accurately and consistently

• Requires minimum number of parameters to reach integration goals

• Cobra Wizard provides:

• Fast, guided way to determine initial detection parameters

Peak Detection – Cobra Wizard

Peak Detection – Cobra Wizard

Start Cobra Wizard

Define the integration range

Select the narrowest peak to be integrated

Select the smallest peak to be integrated

Peak Detection – Cobra Wizard

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And your integration is done!

Peak Detection - SmartPeaks

• Unique tool for easily reaching your integration goals for unresolved peaks

• Requires no training

• Great example of Operational Simplicity • Process is clear and understandable • Requires only a few steps • Correctly integrates all unresolved peaks in seconds

Peak Detection – SmartPeaks

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Activate SmartPeaks Wizard

Select area of interest

Select the integration you want

Peak Detection – SmartPeaks

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And your integration is done!

eWORKFLOWS™

The Ultimate in Operational Simplicity

eWorkflows

• eWorkflows automate all chromatography processes

• Applies to all laboratories, for example: • QA/QC laboratories • Method development laboratories • Research & Development laboratories • Walk-up instrument workflows

• Takes you from Samples to Results in only a few steps

eWorkflows

• An eWorkflow brings together all aspects of a chromatography run: • Instruments which are allowed to run this application • All associated files:

• Instrument Methods • Processing Methods • Reports • Spectral Libraries • Documents with description of method

• Template for sequence name and storage location • Custom Variables • Rules for sequence layout

eWorkflows – A Regulated USP/EP Method

Choose eWorkflow, select instrument, and click “Start”

Enter number of samples, and start position

Sequence is created and can be immediately run

eWorkflows – A Regulated USP/EP Method

• This eWorkflow also:

• Processes all data

• Calculates all results

eWorkflows – From Samples to Results

• eWorkflows take you from Sample to Results in the minimum number of steps

• Fully customizable for any application

• Minimum amount of training required

• Reduces errors and produces results faster

• A new framework for Operational Simplicity

INTERACTIVE CHARTING

Data Visualization

• Interactive Charts for Data Visualization

• Fully customizeable • Templates for the most

common tasks • Available for both on-screen

and printed/exported reports.

Interactive Charting

● Various Chart types

Pie Chart 2D / 3D

Stacked Column 2D / 3D

Scatter Plot

Interactive Charting: Examples

Product Stability

Active Rel.Area % vs. Impurity Rel.Area %.

Query performed on SQL Server database on all data (including historical)

Interactive Charting: Examples

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Instrument Utilization

Interactive Charting: Examples

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Column Performance

REPORTING

Spreadsheet Based Reporting • The Excel-like report

environment is both familiar and intuitive.

• If Excel is used for additional calculations they can be included in Chromeleon.

• No data transcription or export to Excel is required.

• Results are generated instantly.

Spreadsheet Based Reporting

Excel-like formulae can be included for custom

calculations

In this case the operator has configured a report to flag out of specification results.

Report Designer - Functions

Many Excel-like functions available – use identical syntax

AVERAGE IF / AND / OR STDEV COUNT SUM LOOKUP etc……

Report Designer – Export Options

1. TXT

2. PDF

3. XLS

SUPPORT FOR THIRD PARTY INSTRUMENTS

Instrument Control

• Chromeleon 7 can control Thermo Scientific LC, GC and IC.

• Chromeleon 7 can control 3rd Party LCs and GCs

• Agilent 1100, 1200, 1260, 1290, G1888, 6850, 6890, 7890

• Waters Acquity, Alliance • Shimadzu LC10, LC2010, LC20

• Chromeleon 6.8 controls over 330 different

modules from 30 different manufacturers. • These drivers are being converted to CM7

Interfacing with 3rd Party Instruments

● Formal Code Exchange agreements with major manufacturers: ● Waters ● Agilent ● CTC ● Shimadzu

● For other manufacturers we rely on openly published codes ● e.g. GSIOC codes for Gilson systems

● For some manufacturers we provide a Driver Development Kit ● Merck Hitachi

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SUMMARY

Chromeleon 7 – Simply Intelligent

• Contains the Intelligent Functionality needed to generate the result!

• Uses Operational Simplicity™ to minimize the steps and time needed to generate the result!

• Offers state-of-the-art technology: • User Interface with “Ribbon” • COBRA Peak Detection Algorithm & Wizard • SmartPeaks Integration Assistant • eWorkflows – THE framework for Operational Simplicity • Advanced Interactive Charting • Advanced Reporting

• Permits control of multiple vendors equipment from one application.

Chromeleon 7 – Simply Intelligent

Questions?

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