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Chapter 4b: Connective Tissue. Most abundant and widely distributed tissue type Four classes Connective tissue proper Cartilage Bone tissue Blood. Table 4.1. Major Functions of Connective Tissue. Binding and support Protection Insulation Transportation (blood). - PowerPoint PPT Presentation
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Copyright © 2010 Pearson Education, Inc.
Chapter 4b: Connective Tissue
• Most abundant and widely distributed tissue type
• Four classes
• Connective tissue proper
• Cartilage
• Bone tissue
• Blood
Copyright © 2010 Pearson Education, Inc. Table 4.1
Copyright © 2010 Pearson Education, Inc.
Major Functions of Connective Tissue
• Binding and support
• Protection
• Insulation
• Transportation (blood)
Copyright © 2010 Pearson Education, Inc.
Characteristics of Connective Tissue
• Connective tissues have:
• Mesenchyme as their common tissue of origin
• Varying degrees of vascularity
• Cells separated by nonliving extracellular matrix (ground substance and fibers)
Copyright © 2010 Pearson Education, Inc.
Structural Elements of Connective Tissue
• Ground substance• Medium through which solutes diffuse between blood
capillaries and cells
• Components:
• Interstitial fluid
• Adhesion proteins (“glue”)
• Proteoglycans
• Protein core + large polysaccharides (chrondroitin sulfate and hyaluronic acid)
• Trap water in varying amounts, affecting the viscosity of the ground substance
Copyright © 2010 Pearson Education, Inc.
Structural Elements of Connective Tissue
• Three types of fibers
• Collagen (white fibers)
• Strongest and most abundant type
• Provides high tensile strength
• Elastic
• Networks of long, thin, elastin fibers that allow for stretch
• Reticular
• Short, fine, highly branched collagenous fibers
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Structural Elements of Connective Tissue
• Cells
• Mitotically active and secretory cells = “blasts”
• Mature cells = “cytes”
• Fibroblasts in connective tissue proper
• Chondroblasts and chondrocytes in cartilage
• Osteoblasts and osteocytes in bone
• Hematopoietic stem cells in bone marrow
• Fat cells, white blood cells, mast cells, and macrophages
Copyright © 2010 Pearson Education, Inc. Figure 4.7
Macrophage
Fibroblast
Lymphocyte
Fat cellMast cell
Neutrophil
Capillary
Cell types Extracellularmatrix
Fibers• Collagen fiber• Elastic fiber• Reticular fiber
Ground substance
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Connective Tissue: Embryonic
• Mesenchyme—embryonic connective tissue
• Gives rise to all other connective tissues
• Gel-like ground substance with fibers and star-shaped mesenchymal cells
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Overview of Connective Tissues
• For each of the following examples of connective tissue, note:
• Description
• Function
• Location
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Connective Tissue Proper
• Types:
• Loose connective tissue• Areolar
• Adipose
• Reticular
• Dense connective tissue• Dense regular
• Dense irregular
• Elastic
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(a) Connective tissue proper: loose connective tissue, areolar
Description: Gel-like matrix with allthree fiber types; cells: fibroblasts,macrophages, mast cells, and somewhite blood cells.
Function: Wraps and cushionsorgans; its macrophages phagocytizebacteria; plays important role ininflammation; holds and conveystissue fluid.Location: Widely distributed underepithelia of body, e.g., forms laminapropria of mucous membranes;packages organs; surroundscapillaries.
Photomicrograph: Areolar connective tissue, asoft packaging tissue of the body (300x).
Epithelium
Laminapropria
Fibroblastnuclei
Elasticfibers
Collagenfibers
Figure 4.8a
Copyright © 2010 Pearson Education, Inc. Figure 4.8b
(b) Connective tissue proper: loose connective tissue, adipose
Description: Matrix as in areolar,but very sparse; closely packedadipocytes, or fat cells, havenucleus pushed to the side by largefat droplet.
Function: Provides reserve foodfuel; insulates against heat loss;supports and protects organs.
Location: Under skin in thehypodermis; around kidneys andeyeballs; within abdomen; in breasts.
Photomicrograph: Adipose tissue from thesubcutaneous layer under the skin (350x).
Nucleus offat cell
Vacuolecontainingfat droplet
Adiposetissue
Mammaryglands
Copyright © 2010 Pearson Education, Inc. Figure 4.8c
(c) Connective tissue proper: loose connective tissue, reticular
Description: Network of reticularfibers in a typical loose groundsubstance; reticular cells lie on thenetwork.
Function: Fibers form a soft internalskeleton (stroma) that supports othercell types including white blood cells,mast cells, and macrophages.
Location: Lymphoid organs (lymphnodes, bone marrow, and spleen).
Photomicrograph: Dark-staining network of reticularconnective tissue fibers forming the internal skeletonof the spleen (350x).
Spleen
White bloodcell(lymphocyte)
Reticularfibers
Copyright © 2010 Pearson Education, Inc. Figure 4.8d
(d) Connective tissue proper: dense connective tissue, dense regular
Description: Primarily parallelcollagen fibers; a few elastic fibers;major cell type is the fibroblast.
Function: Attaches muscles tobones or to muscles; attaches bonesto bones; withstands great tensilestress when pulling force is appliedin one direction.
Location: Tendons, mostligaments, aponeuroses.
Photomicrograph: Dense regular connectivetissue from a tendon (500x).
Shoulderjoint
Ligament
Tendon
Collagenfibers
Nuclei offibroblasts
Copyright © 2010 Pearson Education, Inc. Figure 4.8e
(e) Connective tissue proper: dense connective tissue, dense irregular Description: Primarilyirregularly arranged collagenfibers; some elastic fibers;major cell type is the fibroblast.Function: Able to withstandtension exerted in manydirections; provides structuralstrength.Location: Fibrous capsules oforgans and of joints; dermis ofthe skin; submucosa ofdigestive tract.
Photomicrograph: Dense irregularconnective tissue from the dermis of theskin (400x).
Collagenfibers
Nuclei offibroblasts
Fibrousjointcapsule
Copyright © 2010 Pearson Education, Inc. Figure 4.8f
(f) Connective tissue proper: dense connective tissue, elastic
Description: Dense regularconnective tissue containing a highproportion of elastic fibers.
Function: Allows recoil of tissuefollowing stretching; maintainspulsatile flow of blood througharteries; aids passive recoil of lungsfollowing inspiration.
Location: Walls of large arteries;within certain ligaments associatedwith the vertebral column; within thewalls of the bronchial tubes.
Elastic fibers
Aorta
HeartPhotomicrograph: Elastic connective tissue inthe wall of the aorta (250x).
Copyright © 2010 Pearson Education, Inc.
Connective Tissue: Cartilage
• Three types of cartilage:
• Hyaline cartilage
• Elastic cartilage
• Fibrocartilage
Copyright © 2010 Pearson Education, Inc. Figure 4.8g
(g) Cartilage: hyaline
Description: Amorphous but firmmatrix; collagen fibers form animperceptible network; chondroblastsproduce the matrix and when mature(chondrocytes) lie in lacunae.Function: Supports and reinforces;has resilient cushioning properties;resists compressive stress.
Location: Forms most of theembryonic skeleton; covers the endsof long bones in joint cavities; formscostal cartilages of the ribs; cartilagesof the nose, trachea, and larynx.
Photomicrograph: Hyaline cartilage from thetrachea (750x).
Costalcartilages
Chondrocytein lacuna
Matrix
Copyright © 2010 Pearson Education, Inc. Figure 4.8h
(h) Cartilage: elasticDescription: Similar to hyalinecartilage, but more elastic fibersin matrix.
Function: Maintains the shapeof a structure while allowinggreat flexibility.
Location: Supports the externalear (pinna); epiglottis.
Photomicrograph: Elastic cartilage fromthe human ear pinna; forms the flexibleskeleton of the ear (800x).
Chondrocytein lacuna
Matrix
Copyright © 2010 Pearson Education, Inc. Figure 4.8i
(i) Cartilage: fibrocartilageDescription: Matrix similar tobut less firm than that in hyalinecartilage; thick collagen fiberspredominate.
Function: Tensile strengthwith the ability to absorbcompressive shock.
Location: Intervertebral discs;pubic symphysis; discs of kneejoint.
Photomicrograph: Fibrocartilage of anintervertebral disc (125x). Special stainingproduced the blue color seen.
Intervertebraldiscs
Chondrocytesin lacunae
Collagenfiber
Copyright © 2010 Pearson Education, Inc. Figure 4.8j
(j) Others: bone (osseous tissue)Description: Hard, calcifiedmatrix containing many collagenfibers; osteocytes lie in lacunae.Very well vascularized.Function: Bone supports andprotects (by enclosing);provides levers for the musclesto act on; stores calcium andother minerals and fat; marrowinside bones is the site for bloodcell formation (hematopoiesis).Location: Bones
Photomicrograph: Cross-sectional viewof bone (125x).
Lacunae
Lamella
Centralcanal
Copyright © 2010 Pearson Education, Inc. Figure 4.8k
(k) Others: bloodDescription: Red and whiteblood cells in a fluid matrix(plasma).
Function: Transport ofrespiratory gases, nutrients,wastes, and other substances.
Location: Contained withinblood vessels.
Photomicrograph: Smear of human blood (1860x); twowhite blood cells (neutrophil in upper left and lymphocytein lower right) are seen surrounded by red blood cells.
Neutrophil
Red bloodcells
Lymphocyte
Plasma
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Nervous Tissue
• Nervous system (more detail with the Nervous System, Chapter 11)
Copyright © 2010 Pearson Education, Inc. Figure 4.9
Photomicrograph: Neurons (350x)
Function: Transmit electricalsignals from sensory receptorsand to effectors (muscles andglands) which control their activity.Location: Brain, spinalcord, and nerves.
Description: Neurons arebranching cells; cell processesthat may be quite long extend fromthe nucleus-containing cell body;also contributing to nervous tissueare nonirritable supporting cells(not illustrated).
Dendrites
Neuron processes Cell body
Axon
Nuclei ofsupportingcells
Cell bodyof a neuron
Neuronprocesses
Nervous tissue
Copyright © 2010 Pearson Education, Inc.
Muscle Tissue
• Skeletal muscle (more detail with the Muscular System, Chapter 10)
Copyright © 2010 Pearson Education, Inc. Figure 4.10a
(a) Skeletal muscleDescription: Long, cylindrical,multinucleate cells; obviousstriations.
Function: Voluntary movement;locomotion; manipulation of theenvironment; facial expression;voluntary control.Location: In skeletal musclesattached to bones oroccasionally to skin.
Photomicrograph: Skeletal muscle (approx. 460x).Notice the obvious banding pattern and thefact that these large cells are multinucleate.
Nuclei
Striations
Part ofmuscle fiber (cell)
Copyright © 2010 Pearson Education, Inc.
Muscle Tissue
• Cardiac muscle (more detail with the Cardiovascular System, Chapters 18 and 19)
Copyright © 2010 Pearson Education, Inc. Figure 4.10b
(b) Cardiac muscleDescription: Branching, striated, generally uninucleate cells that interdigitate atspecialized junctions (intercalated discs).
Function: As it contracts, it propels blood into the circulation; involuntary control.Location: The walls of the heart.
Photomicrograph: Cardiac muscle (500X);notice the striations, branching of cells, andthe intercalated discs.
Intercalateddiscs
Striations
Nucleus
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Muscle Tissue
• Smooth muscle
Copyright © 2010 Pearson Education, Inc. Figure 4.10c
(c) Smooth muscleDescription: Spindle-shapedcells with central nuclei; nostriations; cells arranged closely to form sheets.
Function: Propels substancesor objects (foodstuffs, urine,a baby) along internal passage-ways; involuntary control.Location: Mostly in the wallsof hollow organs.
Photomicrograph: Sheet of smooth muscle (200x).
Smoothmusclecell
Nuclei
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Epithelial Membranes
• Cutaneous membrane (skin) (More detail with the Integumentary System, Chapter 5)
Copyright © 2010 Pearson Education, Inc. Figure 4.11a
Cutaneousmembrane(skin)
(a) Cutaneous membrane (the skin)covers the body surface.
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Epithelial Membranes
• Mucous membranes
• Mucosae
• Line body cavities open to the exterior (e.g., digestive and respiratory tracts)
Copyright © 2010 Pearson Education, Inc. Figure 4.11b
Mucosa ofnasal cavity
Mucosa oflung bronchi
Mucosa ofmouth
Esophaguslining
(b) Mucous membranes line body cavitiesopen to the exterior.
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Epithelial Membranes
• Serous Membranes
• Serosae—membranes (mesothelium + areolar tissue) in a closed ventral body cavity
• Parietal serosae line internal body walls
• Visceral serosae cover internal organs
Copyright © 2010 Pearson Education, Inc. Figure 4.11c
Parietalpericardium
Visceralpericardium
(c) Serous membranes line body cavitiesclosed to the exterior.
Parietalperitoneum
Visceralperitoneum
ParietalpleuraVisceralpleura
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Steps in Tissue Repair
• Inflammation
• Release of inflammatory chemicals
• Dilation of blood vessels
• Increase in vessel permeability
• Clotting occurs
Copyright © 2010 Pearson Education, Inc. Figure 4.12, step 1
Scab
Blood clot inincised wound
Epidermis
Vein
Inflammatorychemicals
Inflammation sets the stage:• Severed blood vessels bleed and inflammatory chemicals are
released.• Local blood vessels become more permeable, allowing white
blood cells, fluid, clotting proteins and other plasma proteinsto seep into the injured area.
• Clotting occurs; surface dries and forms a scab.
Migrating whiteblood cell
Artery
1
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Steps in Tissue Repair
• Organization and restored blood supply
• The blood clot is replaced with granulation tissue
• Epithelium begins to regenerate
• Fibroblasts produce collagen fibers to bridge the gap
• Debris is phagocytized
Copyright © 2010 Pearson Education, Inc. Figure 4.12, step 2
Regeneratingepithelium
Area ofgranulationtissueingrowth FibroblastMacrophage
Organization restores the blood supply:• The clot is replaced by granulation tissue, which restores
the vascular supply.• Fibroblasts produce collagen fibers that bridge the gap.• Macrophages phagocytize cell debris.• Surface epithelial cells multiply and migrate over the
granulation tissue.
2
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Steps in Tissue Repair
• Regeneration and fibrosis
• The scab detaches
• Fibrous tissue matures; epithelium thickens and begins to resemble adjacent tissue
• Results in a fully regenerated epithelium with underlying scar tissue
Copyright © 2010 Pearson Education, Inc. Figure 4.12, step 3
Regeneratedepithelium
Fibrosedarea
Regeneration and fibrosis effect permanent repair:• The fibrosed area matures and contracts; the epitheliumthickens.• A fully regenerated epithelium with an underlying area ofscar tissue results.
3
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Developmental Aspects
• Primary germ layers: ectoderm, mesoderm, and endoderm• Formed early in embryonic development
• Specialize to form the four primary tissues
• Nerve tissue arises from ectoderm
• Muscle and connective tissues arise from mesoderm
• Epithelial tissues arise from all three germ layers
Copyright © 2010 Pearson Education, Inc. Figure 4.13
MesodermEndoderm
16-day-old embryo(dorsal surface view)
EpitheliumNervous tissue(from ectoderm)
Muscle and connectivetissue (mostly frommesoderm)Ectoderm
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