Ch. 23. - Ulsanocw.ulsan.ac.kr/OCWData/2010/02/E01453-01/LectureNotes...NMDA receptors activated by...

Ch. 23.Wiring the Brain

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, pp 690-723.

NeurogenesisSynaptogenesisSynaptic remodeling

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 690.

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 692.

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 691.

Adult neurogenesis

Distribution of cell constituents in precursor cells

Bear et al., Neuroscience: Exploring the Brain, 2nd ed., Lippincott Williams & Wilkins, 2001, p 709.

Bear et al., Neuroscience: Exploring the Brain, 2nd ed., Lippincott Williams & Wilkins, 2001, p 710.

Inside-out development of the cortex

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 695.

Differentiation of a neuroblast into a neuron

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 696.

Synaptogenesis1) Pathway selection2) Target selection3) Address selection

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006,pp 697.

Growth cone of the growing axon tip

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 698.

Fasciculationtract

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 699.

Axon guidance:Guidance cuesChemoattractantChemorepellent Chemoattractant

ChemorepellentEx) ephrines

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 700.

ephrines

Establishing retinotopy in the frog retinotectal projection

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 703.

Formation of a neuromuscular synapse

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 704.

Matching inputs with targets by selective cell death

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 706.

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 708.

Synapse elimination

Synaptic rearrangement

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 709.

Plasticity at Hebb synapse

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 710.

Bear et al., Neuroscience: Exploring the Brain, 2nd ed., Lippincott Williams & Wilkins, 2001, p 725.

Segregation of ocular dominance columns in cat striate cortex

Modification of ocular dominance stripes after monocular deprivation

Normal

Monocularly deprived

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 712.

Synaptic convergence at layers 2 and 3

S

S C

S: segregatedC: converged

Bear et al., Neuroscience: Exploring the Brain, 2nd ed., Lippincott Williams & Wilkins, 2001, p 729.

Bear et al., Neuroscience: Exploring the Brain, 2nd ed., Lippincott Williams & Wilkins, 2001, p 729.

Effects of strabismus on cortical binocularity

normal

strabismus

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 712.

Dependence of plasticity of binocular connections on modulatory inputs

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 716.

Neurons that fire together wire together.Neurons that fire out of synchronization lose their link.

Excitatory synaptic transmission in the immature visual system

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 717.

NMDA receptors activated by simultaneous presynaptic and postsynaptic activity

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 718.

The lasting synaptic effects of strong NMDA receptor activation

Bear et al., Neuroscience: Exploring the Brain, 3rd ed., Lippincott Williams & Wilkins, 2006, p 719.

Bear et al., Neuroscience: Exploring the Brain, 2nd ed., Lippincott Williams & Wilkins, 2001, p 736.