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Cell Injury
Slide 11:Vacuolar Degeneration Kidney
• Renal tubules– Note tiny small vacuoles– Displaced nucleus to the side
• Glomerulus
Slide 30Intestine Caseation Necrosis
Casseation Necrosis - Tuberculosis - • Irreversible injury• Grossly = like cheese – soft, whitish, crumbly -
casseous cassation necrosis• Surrounded by epitheloid cells, giant cells,
necrotic area.• On X-ray report: Fibrocasseous density• Fibrotic center • After treatment: fibrocalcitic area/fibrotic area
Slide 96:Enzymatic Fat Necrosis (Pancreas)Acute hemorrhagic pancreatitis necrosis• Exocrine function -- CHO, Fats, Lipid enzymes• Enzymes leak out of pancreas – lipase digests • Peripancreatic tissue gets digested produced fatty
acids, and stays in the tissue.• Sapponified fat - see shadowy outlines of the fat cells,
containing this. Whitish, opaque, crumbly.• Severe abdominal pain. • Note the following:
– Normal pancreatic tissue– Necrosis of peripancreatic fats by enzymes released from
pancreas
Slide: (no number)Lung Abscess
Abscess - plenty of neutrophils/enzymes• Irreversible• Heterolysis• Liquifies tissue• Pus formation• Note
– Lung abscess – digestion of lung tissue producing a cavity filled with neutrophils and necrotic material
– Alveoli with PMNs and edema
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