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Cell Communication III
G-protein linked receptor
The structure of an inactive G-protein
Without signaling molecule G-protein is inactive
G-protein binds to receptor when signaling molecule is present
G-protein accepts GTP and disassemble into two active subunits
The α subunit of the G-protein can be deactivated through hydrolysis of GTP
Deactivation of G-protein
Reassembly of α subunit with other 2 subunits reforms inactive G-protein complex
Arrestin binds phosphorylated G-protein receptor and deactivates the receptor and
prepares it for endocytosis
Activation of gene transcription by cAMP
Synthesis and degradation of cyclic AMP
Activation of cAMP dependent protein kinase
Activation of gene transcription by cAMP
Ca2+ and diacylglycerol activate protein kinase C
Fertilization of an egg by a sperm triggers an increase in cytosolic Ca 2+
Ways in which a cell maintains a low Ca 2+ concentration in the cytosol
Ways in which a cell maintains a low Ca 2+ concentration in the cytosol
When receptor chains crosslink the receptor is phosphorylated and activated
Human growth hormone bound to its receptor tyrosine kinase
Activated receptor kinase binds intracellular signaling proteins
Ras is activated by tyrosine kinase
The Jak-STAT signaling pathway provides a fast track to the nucleus
The Jak-STAT signaling pathway provides a fast track to the nucleus
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