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Carl Zeiss MicroImaging AIS
Solutions for DigitalPathology
Andrew LesniakDirector, Product Management
UpdateZeiss, Trestle, Clarient (ACIS)
The Device technology group was acquired from Clarient Inc., by Carl Zeiss in March 2007. Combined installation base of 600+ Units worldwide.
Full acquisition – including both the Trestle and the ACIS family of products
New entity formed under Carl Zeiss – Carl Zeiss MicroImaging AIS
Commitment to the technology portfolio, including:
- Integration into the Carl Zeiss Support structure (worldwide).
- Committed R&D investments for technology enhancement.
- Interoperability with the existing Zeiss product portfolio; including Image Acquisition, Mirax™ Platforms, and advanced technologies such as the PALM MicroBeam platform for Genomic and Phenotype applications.
Light Microscopy
macro
Advanced Imaging Microscopy Digital Pathology Solutions
Classical Technologies Imaging Laser Digital Detection
cellular
molecular
Technology
Applications For Digital Pathology Information Management:
•Leading Computer Aided Diagnostics and Analysis
•AP Workflow and Educational Data Management
Leveraging a Leading Product Portfolio for a
Complete Pathology Imaging Solution
Scalable Product Constellation
• Small footprint
• 20x Plan-Apo objective with 0.8 NA
• Image capture from barcode area w/ barcode identification
• Optional 40x Plan-Apo objective with 0.95 NA
• Choice of different camera adaptors (1x or 0.63x)
• Optovar option (1.25x and 1.6x)
• Fluorescence option
Resolution range from 0.11 µm/pixel ... 0.52 µm/pixel
MIRAX Lab Automation Digital Pathology Solution
• Zeiss Microscope Platform and Optics Configuration
• Full Robotic Telepathology functionality, including focal control, condenser settings
• Scalable to Digital Whole Slide Acquisition with user selectable Objective (4, 10, 20, 40, 60)
• Multi-focal plane imaging and robust focus technology ensures for robust imaging capability.
• Automated Slide Handling of 1, 4, 50 slides
• Fluorescence Multi-Channel Capable
MIRAX Micro Robotic Digital Pathology Solution
Overlay Extended FocusReal-Time Acquisition of
image series from different focus positions
Unique Scanning Advancements: MicroField Acquisition
Multi channel FluorescenceImage acquisition in several individual fluorescence channels
DAPI
Overlay
TexasRed
FITC
Scanning Advancements: Multi-channel
Fluorescence Acquisition
Digital Pathology Analysis:
Innovations with Imaging
Tissue Scoring and Quantitative Analysis Membrane StainsNuclear stainsIntegrated Optical Density
Rare Event Detection Sentinel Lymph nodesBone marrow
Object Detection and CountingNuclear Cell Counting,Micro-Vessel Density, Ploidy
Tissue Micro Array Scoring
Red blood cells
ICC-negative lymphoid cells
ICC-positive lymphoid cells
ICC-negative myeloid cells
ICC-positive myeloid cells
Size Blue Content Brown Contentsmall none/low medium/high
small high none/low
small high medium/high
large high none/low
large high medium/high
Digital Pathology Analysis:
Cellular Classification in Cytospin®
Workflow, Educational and Reference Materials
Virtual Lab creation- organization ofDigital Images by context
Linking a slide to relevant accession,histological and pathological contextinformation
Linking areas of interest on a slideto relevant teaching or lesion specificinformation
Preservation of compound relatedeffects for future reference
Digital Pathology Workflow:
Enabling Scale
We make it visible
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