By: A.Abdeyazdan With best regards to: Dr.M.Mokhtari

IN THE NAME OF GOD

By: A.AbdeyazdanWith best regards to: Dr.M.Mokhtari

Embryo Implantation

What is Embryo Implantation ?

Preimplantation

Embryo- Hatching use of lytic factors

Uterus ( implantation window)-Thickness of endometrial wall- growth of secretory glands 7 days after ovulation- produce of decidual cell 9 to 10 days after ovulation- produce of pinopodes for endocytose - secret of progesterone

Pinopodes

In human are almost on non- villi

Surface of endometrium.

Have mitochondria and glycogen. Produce because of progesterone secreting.

They have villi on their surface that is

Perfect to close the trophoblast to endometrium.

Integrin on pinopodes and muc1 on endometr will help to implantation

Decidualization

EdemaPlace for natural killerSource of nutrients for embryoControl the growth of embryoImmune actionsControl the maternal vesseln system Secret some factors for develop of placentaGrowth factors are important for decidalization10% of gene expression in decidualization is in control of embryo( like EPCR)

Effecter factors in Implantation

Hormones(estrogen, progesterone, prostaglandin)

Growth factors

Cytokines

LIF

Implantation

appositio

n

locationadhesio

n

Blastocyst attach to endometriumwith L-selectin& CCR2, CCR5

Invasion

Breaching of trophoblast

Blastocyst

Early placental development

Cyncytiotrophoblast

Syncytiotrophobalst in Endometrium

The End

Power by: M.Zendehboudi

By: A.AbdeyazdanWith best regards to: Dr.M.Mokhtari

Embryo Implantation