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Akzo Nobel – businessesHuman healthcare, animal healthcare and complex active pharmaceutical ingredients
Car Refinishes, Decorative Coatings Europe, Decorative Coatings International, Industrial Finishes, Marine & Protective Coatings, Nobilas, Powder Coatings
Base Chemicals, Energy, Functional Chemicals, Polymer Chemicals, Pulp & Paper Chemicals (Eka Chemicals), Salt, Surface Chemistry
Pharma
Coatings
Chemicals
Intervet
• Intervet develops and sells veterinary products(vaccines and pharmaceuticals)
• Intervet is represented by 54 commercial companies in 53 countries worldwide
• Intervet has approximately 5,200 employees
• Intervet has 13 R&D and 18 production sites
• Annual investment in R&D exceeds 10% of sales• More than 15% of Intervet’s total workforce in R&D• 13 R&D sites spread around the globe• Major research sites:
Germany:Antiparasitic and anti-infective product discovery and development
France:Specialized pharmaceutical productdevelopment
Centers in NL, UK and US:Bacterial, viral and parasitic vaccine projects
Centers in Norway and Singapore:advanced aquatic animal health products
Research at Intervet
Pioneers of Aquatic Animal Health since 1985Pioneers of Aquatic Animal Health since 1985Pioneers of Aquatic Animal Health since 1985
Intervet Aquatic Animal HealthIntervet Aquatic Animal Health
Aquatic Animal Developmental Diversity
Temperature / Salinity
Aquatic Animal Developmental Aquatic Animal Developmental DiversityDiversity
Temperature / SalinityTemperature / Salinity
Milkfish/ShrimpMulletBrackish
Salmon Asian sea bassBass/BreamMarine
Trout Catfish/TilapiaCarp/EelsFresh
0 - 16 °C 12 - 25 °C 20 - 32 °C
Based on this extreme diversity, Intervet has set up two specialized R&D centres
Based on this extreme diversity, Intervet has set up two specialized R&D centres
Intervet’s Aquatic Animal Health
NorwayColdwater Fish
The NetherlandsHeadquarters
SingaporeTropical Fish
Vaccines - Endocrines - Antiparasitics
Pioneers of Aquatic Animal Health since 1985Pioneers of Aquatic Animal Health since 1985
Matre Research Station
Matre Research Station
Intervet Norbio Singapore Pte. Ltd.(January 2000)
Intervet Norbio Singapore Pte. Ltd.(January 2000)
Dedicated to disease research and product development for aquatic animal health in the Asia-Pacific region
Dedicated to disease research and product development for aquatic animal health in the Asia-Pacific region
The team in Singapore
Major activities at Intervet Norbio Singapore
• R&D• Disease diagnosis, including the detection and identification
of new emerging pathogens• Vaccine development for economically important fish
diseases (bacterial and viral vaccines)• Development of high quality and safe pharmaceuticals for
responsible use in aquaculture
• Technical support• Regional epidemiological disease investigations• Education of fish and shrimp farmers to improve husbandry
and health practices• Technical support to farmers• Marketing support to Intervet local companies
Hatchery
Sex-reversal
1 g 10 g 100 g 1 kg0 g
Path
ogen
Phas
eNursery Pre-grow-out Grow-out
Flavobacterium columnare
RLOEdwardsiella tarda
IridovirusStreptococcus spp. (Sa; Si)
Saprolegnia & Branchiomyces
Nocardia seriolae
Trichodina & Dactylogyrus
Nodavirus?
Note: importance of the disease is roughly in proportion to the size of the arrow bars
Major Diseases Affecting Tilapiaduring the Farming Cycle
0 DOC 45 DOC 80DOC 140DOC 400DOC
0g 1 g 15 g 100 g 3.5 kg
Hatchery phase
(ponds/tanks)
Nursery phase
(tanks)
Pre-grow-out
(small cages)
Grow-out
(Big cages)
Diseases in Asian seabass
Disease cycle
VNN
Big Belly
10 DOC
30DOC
0.3-0.5g
<0.1g
Iridovirus
Tenacibaculum maritimum
Streptococcus iniae
Benedeniaparasites
Best vaccine application method
Immersion Injection
5g
20g
0 DOC 45 DOC 80DOC 140DOC 400DOC
0g 1 g 15 g 100 g 3.5 kg
Hatchery phase
(ponds/tanks)
Nursery phase
(tanks)
Pre-grow-out
(small cages)
Grow-out
(Big cages)
Diseases in Asian seabass
Disease cycle
VNN
Big Belly
10 DOC
30DOC
0.3-0.5g
<0.1g
Iridovirus
Tenacibaculum maritimum
Streptococcus iniae
Benedeniaparasites
Best vaccine application method
Immersion Injection
5g
20g
0 DOC 45 DOC 80DOC 140DOC 400DOC
0g 1 g 15 g 100 g 3.5 kg
Hatchery phase
(ponds/tanks)
Nursery phase
(tanks)
Pre-grow-out
(small cages)
Grow-out
(Big cages)
Diseases in Asian seabass
Disease cycle
VNN
Big Belly
10 DOC
30DOC
0.3-0.5g
<0.1g
Iridovirus
Tenacibaculum maritimum
Streptococcus iniae
Benedeniaparasites
Best vaccine application method
Immersion Injection
5g
20g
0 DOC 45 DOC 80DOC 140DOC 400DOC
0g 1 g 15 g 100 g 3.5 kg
Hatchery phase
(ponds/tanks)
Nursery phase
(tanks)
Pre-grow-out
(small cages)
Grow-out
(Big cages)
Diseases in Asian seabass
Disease cycle
VNN
Big Belly
10 DOC
30DOC
0.3-0.5g
<0.1g
Iridovirus
Tenacibaculum maritimum
Streptococcus iniae
Benedeniaparasites
Best vaccine application method
Immersion Injection
5g
20g
BacteriologyBacteriology
VirologyVirology BiochemistryBiochemistry
DiagnosisDiagnosis
Pilot Production Lab
1,300 L research tanks
Highlights of Intervet Norbio Singapore
• 2000: Intervet Norbio Singapore, first and only private aquatic animal health (AAH) R&D centre established.
• 2003: Intervet participated in the task force for Koi Herpes Virus on request from NACA (Network of Aquaculture Centres in Asia-Pacific) and the Indonesian government.
• 2004: Intervet Norbio Singapore is recognized as a regional resource centre by NACA.
• 2005: Introduction of Intervet's first fish vaccine in Japan, • Norvax® Vibrio mono, an immersion vaccine
against • Vibrio (Listonella) anguillarum infections of
Japanese yellowtail.
• 2005: Introduction of Intervet's first Asian fish vaccine outside Japan, Norvax® Strep Si, an immersion and injection vaccine against Streptococcus iniae infections in warmwater fish.
Other Regional Activities
• Serving as member of the NACA Aquatic Animal Health Advisory Group
• Participation in disease epidemiology study with local universities/institutes/agencies (e.g. P.R. China, Indonesia, Malaysia, Thailand).
• Sponsorship for DAA and CAA
• Trainings, e.g. AVA tilapia course (Singapore), MOA fish diseases and diagnosis (PRC), NACA grouper training course (Indonesia)
• Weekly Asian Aquatic Animal Newsletter
• …
Websites
• www.intervet.com/aah/singapore.asp
• www.thefishsite.com/
Potential collaboration among Intervet, NACA and other organizations
• What we can give:– Knowledge/facility in aquatic animal health
(diseases, diagnosis and health management)
– Solution for sustainable aquaculture –vaccines
– Funding
• What we want to take:– Source of epidemiology data– Facilitation of field trials– Support on vaccination program as part of
health management practice: education
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