Adiponectin versus angiotensin II: Key pathological role of their misbalance

Adiponectin versus angiotensin II:

Key pathological role of their misbalance

RAS inhibit adiponectin production

RAS interacts with adiponectin in their target cells

Ang Ⅱ inhibit adiponectin production

Diabetologia (2005) 48: 1066–1074

Diabetologia (2005) 48: 1066–1074

Blockade of the Renin-Angiotensin System Increases

Adiponectin Concentrations

Hypertension. 2003;42:76-81.

Mechanism:

Olmesartan, an Ang II type-1 (AT1) receptor blocker (ARB),

inhibits overexpression of NADPH subunits and a transcriptional Factor

-PU1 (which upregulates the transcription of NADPH oxidase subunits)

Olmesartan meliorates dysregulation of other adipokines, including tumor

necrosisfactor-α, plasminogen activator inhibitor-1, serum amyloid A3,

and monocyte chemotactic protein-1.

Kidney Int 2006; 70:1717–1724.

SomeARBs, including irbesartan and telmisartan,have PPARγ-activating

properties, thereby stimulating adiponectin production.

(Circulation. 2004;109:2054-2057.)

AT2 receptor activation in the absence of AT1 receptor activation.

Journal of Neurochemistry, 2005, 94, 1395–1401

Acta Diabetol (2005) 42:S26–S32

Adiponectin-stimulated production of NO in BAEC is

dependent on PI 3-kinase activity.

JBC,2003, 278(45) 45021–45026

NO Production

Curr. Med. Chem. Cardiovascular & Hematological Agents, 2005, 3, 305-322

the proliferation of vascular smooth muscle cells

Adiponectin inhibits PDGF-BB–induced HASMC proliferation and migration.

Circulation. 2002;105:2893-2898.

Circulation. 2002;105:2893-2898.

Angiotensin II Signal Transduction Through Small GTP-

Binding Proteins: Mechanism and Significance in Vascular

Smooth Muscle Cells

Ang II stimulates the ERK cascade through epidermal growth

factor receptor transactivation

Hypertension 2006; 48: 534–540.

Kidney International (2006) 70, 1678–1679.