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8/19/2019 Accord and Advance
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ACCORD
Action to ControlCardiovascular Risk in
Diabetes Trial
Reference:1) https://www.accordtrial.org/public/index.cfm?
CFID!"#"$CF%&'(*+,"+ad#!e+d-*e+FFD10++((,(C#-0"+-*F1#(!-"
#) http://www.nhlbi.nih.go2/health/prof/heart/other/accord/34a.htm
C5&& '&' 7(8 90001"
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8hat is ;CC&RD stud
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• %he stud< began enrollingparticipants in #1 and too> placein -- clinical sites across the @nitedtates and Canada.
• ; total of 1#,1 adults withestablished t
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ACCORD study seek to
answer$
• to determine if a strateg< ofintensi2e lowering of blood sugarle2els intensi2e lowering of bloodpressure or treatment of blood lipidswith a Abrate drug plus a statin drugcan reduce the ris> of maBor CD
e2ents in patients with t of CD.
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5owe2er
• no pre2ious clinical trial had testedthe eects of lowering blood sugaror blood pressure to near%nor&allevels in patients with t
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"hat is the status of theACCORD study$
• ;ll three ;CC&RD clinical trials ha2eended. %he ational 5eart Eung and0lood Institute =5E0I) stopped the
intensi2e blood sugar loweringstrateg< on Februar< + #! due tosafet< concerns.
• %he blood pressure and lipid treatmenttrials continued until the planned endof the stud< in une #.
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1) ACCORD lood )ugarClinical Trial
• ;CC&RD Data and afet< 9onitoring0oard =D90) noticed that there is astatisticall< signiAcant ##G higherrate of death in the intensi2e=5b;1CH +."G) than the standardgroup=5b;1CH-.,G).
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ACCORD lood *ressureClinical Trial
• In the intensive group an a2erage s
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ACCORD 1ipid ClinicalTrial
• Jeople with t
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• statins lowers the rates of heartattac>s and cardio2ascular death
•
Abrate medications are used toincrease the blood le2els of theKgoodL 5DE cholesterol as well asreduce trigl
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8/19/2019 Accord and Advance
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ADVAC3
Action in Diabetes andVascular DiseaseReference:http://www.ad2ancetrial.com
http://www.medicalnewstoda
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;D;C(
• ;D;C( is the largest clinical trialon diabetes e2er conducted o2er11 patients
• %hese patients ha2e come from #dierent countries.
4l l i
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4lucose lowering ar&results
• intensi2e blood glucose control usingDiamicron 9R =gliclaMide modiAed release)and other drugs as re3uired protectspatients against serious complications of
the disease.
• Reduces the o2erall ris> of seriousdiabetes complications b< 1G with a
#1G reduction in >idne< disease and *Greduction in the de2elopment ofmacroalbuminuria=a well establishedmar>er of increased cardio2ascular ris>)
l d l i
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lood pressure loweringar& results
• Jreterax=perindopril and indapamide)signi5cantly reduces total&ortality by +/6 and the ris> of
cardiovacular death by +76.
• In absolute terms one death wouldbe a2oided for e2er< - patients
treated with Jreterax for A2e
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%han>
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