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Academic Global Immersion
BIOTECH LONDONJanuary 3-11, 2011
Dr. Moira Gunn, Lead Facultyemail: gunn@usfca.edu
Dr. Nicholas Imparato, Co-Facultyemail: imparato@usfca.edu
School of Business & Professional Studies
AGI - Biotech London January 3-11, 2011
AGENDA – 9:00-2:00 Introductions Review of Logistics – TA’s Review of Syllabus
Performance Expectations Review of Trip Schedule Scheduling of Executive Interviews Biotech Business Overview @12:15 - lunch with Dubai/Turkey AGI group
AGI - Biotech London January 3-11, 2011
INTRODUCTIONS
Professors TA’s Students –
First Name Degree Program Been on an AGI before? Any biotech courses or employment? Any courses in life science?
AGI - Biotech London January 3-11, 2011
Review of Logistics
TA’s
AGI - Biotech London January 3-11, 2011
Course Syllabus
AGI - Biotech London January 3-11, 2011
Performance Expectations
Academic Work as per syllabus Professional Attire Professional Behavior Appropriate Behavior at all times Respect for Others Traveling as Group
“Stay with the Group”
AGI - Biotech London January 3-11, 2011
Performance Expectations
When traveling in teams “Never lose your wingman”
Physical Security “We stick together”
Concern for Others “We take care of each other”
AGI - Biotech London January 3-11, 2011
Performance Expectations
Cell phone behavior Text/call when asked to Phone off in meetings Check in when plans change Text significant events Keep your phone charged
AGI - Biotech London January 3-11, 2011
Trip Schedule
AGI - Biotech London January 3-11, 2011
Scheduling of
Executive Interviews
AGI - Biotech London January 3-11, 2011
Biotech Business Overview What is the Business of Biotech? The Global Biotech Industry
San Francisco Bay Area The Golden Triangle – UK
London Biotech Cluster Cambridge Biotech Cluster Oxford Biotech Cluster
AGI - Biotech London January 3-11, 2011
Approach Read my book Some overview today I will be sending out material Mini-lectures during the trip
AGI - Biotech London January 3-11, 2011
Definition of
Biotechnology
AGI - Biotech London January 3-11, 2011
Biotechnology is …“The use of living organisms (especially microorganisms) in industrial, agricultural, medical and other technological applications; the application of the principles and practices of engineering and technology to the life sciences.”
- Wikitionary
AGI - Biotech London January 3-11, 2011
Biotechnology is …“The use of the cellular and molecular
processes to solve problems or makeproducts."
- Biotechnology Industry Organization (BIO)
AGI - Biotech London January 3-11, 2011
Biotechnology is …“Any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify
products or processes for specific use.”
- United Nations Convention on Biological Diversity
AGI - Biotech London January 3-11, 2011
Biotechnology is …“refers to techniques used by scientists to modify deoxyribonucleic acid (DNA) or the genetic material of a microorganism, plant, or animal in order to achieve a desired trait.”
- Food & Drug Administration (FDA)
AGI - Biotech London January 3-11, 2011
Biotechnology is …
“You take anything biological, and you tinker with it using today’s gene tools.
… Get it? Biotech.”
- Dr. Moira Gunn
AGI - Biotech London January 3-11, 2011
“Minimalist Science”
“The least you need to know
to get the point”
AGI - Biotech London January 3-11, 2011
What is DNA?
AGI - Biotech London January 3-11, 2011
What is DNA?
… Deoxyribonucleic Acid
AGI - Biotech London January 3-11, 2011
What is DNA?
AGI - Biotech London January 3-11, 2011
What is DNA?
AGI - Biotech London January 3-11, 2011
When you go in to buy a car …
AGI - Biotech London January 3-11, 2011
When you go in to buy a car …
… they don’t tell you about the inner workings
of the internal combustion engine
AGI - Biotech London January 3-11, 2011
What is DNA?
AGI - Biotech London January 3-11, 2011
What is DNA?
Let’s start with
something we all know
AGI - Biotech London January 3-11, 2011
What is DNA?
Let’s start with
something we all know
… our computers
AGI - Biotech London January 3-11, 2011
Our personal computers have programs …
PC’s Windows – operating system Internet Explorer – surfing Microsoft WORD – for writing Adobe Acrobat, et al
AGI - Biotech London January 3-11, 2011
Or on the Apple…
Apple’s Mac OS – operating system Safari – surfing Microsoft WORD – for writing Adobe Acrobat, et al
AGI - Biotech London January 3-11, 2011
Each computer program …
Is a long list of instructions First do this … then do that Instructions that your computer understands
AGI - Biotech London January 3-11, 2011
The instructions tell the computer hardware
How to store our files when we “Save” What part of the screen our cursor is at
when we click on our mouse They even put the cursor up on the
screen itself Everything you do, see, experience on
your computer – including the blue screen of death – is the result of a list of instructions
AGI - Biotech London January 3-11, 2011
The same is true
for your body and its DNA
AGI - Biotech London January 3-11, 2011
The same is true
for your body and its DNA
DNA is to your body
what application programs
are to your computer …
AGI - Biotech London January 3-11, 2011
The same is true
for your body and its DNA
DNA is to your body
what application programs
are to your computer …
The instructions of how it works
AGI - Biotech London January 3-11, 2011
Your DNA tells your body
How to operate … To produce insulin so that you can
process sugars after you eat To produce antibodies when it notices
harmful substances To grow to the height that you are To tell your cells to replicate so that you
can continue to live throughout your life
AGI - Biotech London January 3-11, 2011
What happens if you don’t have an application program on your computer?
AGI - Biotech London January 3-11, 2011
What happens if you don’t have an application program on your computer?
No Internet Explorer – no Internet
AGI - Biotech London January 3-11, 2011
What happens if you don’t have an application program on your computer?
No Internet Explorer – no Internet
What happens if you have no DNA sequence to tell your body to produce insulin?
AGI - Biotech London January 3-11, 2011
What happens if you don’t have an application program on your computer?
No Internet Explorer – no Internet
What happens if you have no DNA sequence to tell your body to produce insulin?
You are a Type I diabetic
AGI - Biotech London January 3-11, 2011
Your DNA is within every one of your cells Human body constantly replaces its cells Every time a new cell is generated
It copies your DNA Sometimes, it makes a mistake in
copying, and tiny changes can occur This is called “mutating” Resulting in “mutations” And sometimes bad results …
AGI - Biotech London January 3-11, 2011
What happens if your operating systems program becomes corrupted?
AGI - Biotech London January 3-11, 2011
What happens if your operating systems program becomes corrupted?
The performance declines
AGI - Biotech London January 3-11, 2011
What happens if your operating systems program becomes corrupted?
The performance declines
What happens if the DNA sequence in some of your cells change in a bad way?
AGI - Biotech London January 3-11, 2011
Humans have DNA …
… what else does?
AGI - Biotech London January 3-11, 2011
Humans have DNA …
… what else does?
Any living organism
AGI - Biotech London January 3-11, 2011
Humans have DNA …
… what else does?
Any living organism
Animals, fish, trees, plants, bacteria, viruses, …
AGI - Biotech London January 3-11, 2011
Humans have DNA …
… what else does?
Any living organism
Animals, fish, trees, plants, bacteria, viruses, …
What doesn’t have DNA?
AGI - Biotech London January 3-11, 2011
Humans have DNA …
… what else does?
Any living organism
Animals, fish, trees, plants, bacteria, viruses, …
What doesn’t have DNA?
Rocks, water, air, clothes, cars, …
AGI - Biotech London January 3-11, 2011
Scientists known about DNA since the mid-1850’s They could see various instructions
“1/2 tsp. sugar” “Fill up car with gas” “Do math homework”
But they couldn’t see the list – the sequence And they couldn’t see the structure
In 1953, James Watson & Francis Crick published the structure of DNA The Double Helix (Don’t get me started on Rosalind Franklin)
AGI - Biotech London January 3-11, 2011
What is DNA?
AGI - Biotech London January 3-11, 2011
What is DNA?
AGI - Biotech London January 3-11, 2011
Quick Definition
Why do we use the terms “GENETIC” and “GENETICS”? “Genes” are portions, stretches, sequences of DNA Same as a sequential list of instructions within a
computer program
AGI - Biotech London January 3-11, 2011
How did we get from Watson and Crick
to the Business of Biotech?
AGI - Biotech London January 3-11, 2011
In the late 60’s – the technology to splice into that twisted spiral came into being
Thus enabling scientists to produce
“Recombinant DNA”
“Recombinant DNA” is DNA that does not exist naturally – it is created by combining DNA sequences that would not normally occur together
“Recombinant DNA” ... is engineered DNA … it is Biotech
AGI - Biotech London January 3-11, 2011
In the late 60’s – the technology to splice into that twisted spiral came into being
Thus enabling scientists to produce
“Recombinant DNA”
“Recombinant DNA” is DNA that does not exist naturally – it is created by combining DNA sequences that would not normally occur together
“Recombinant DNA” ... is engineered DNA … it is Biotech
AGI - Biotech London January 3-11, 2011
San Francisco Biotech Cluster
* The largest in the world *
AGI - Biotech London January 3-11, 2011
UK Biotech Cluster
London/Oxford/Cambridge
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