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Clinical study essentials
• Randomized, double-blind, parallel, clinical study• 80 participants completed the study• 3 weeks study duration• Conducted at Chengdu, People’s Republic of China. • Accepted for publication in Journal of Clinical Dentistry, 2018. Hu et al, A clinical investigation of the effi cacy of a Dual Zinc plus Arginine toothpaste for controlling oral malodor
Implication for practiceColgate® Total toothpaste with Dual Zinc and Arginine provides patients with superior oral malodor control, even 12 hours after brushing, in comparison to a regular fl uoride toothpaste after three weeks of continuous use.
In this clinical study the effi cacy of a new Colgate® Total with Dual Zinc plus Arginine toothpaste was assessed for the 12 hour overnight oral malodor reduction after 3 weeks of product use.
• After 3 weeks of product use, 90 % of the group using Colgate® Total experienced a shift toward “pleasant” breath (Figure 1). • Subjects using Colgate® Total showed a statistically signifi cant reduction of 38.9 % in organoleptic scores as compared to baseline (Figure 2). • Relative to the regular fl uoride toothpaste group, subjects in the Colgate® Total group exhibited statistically signifi cant reduction of 30.8 % in oral malodor.
Results
A Clinical Investigation proves the efficacy of Colgate® Total for controlling Oral Malodor
Regular Fluoride toothpaste
Dual Zinc plus Arginine toothpaste
Overnight (12 hr) Post Brushing versus BaselinePe
rcen
t Red
ucti
on0
5
1015
20
25
30
35
40
45Percent Change in Organoleptic scores
*
Figure 2. Percent Change in Organoleptic Scores
0
1
23
4
5
6
7
8
9
Baseline 12 Hours
Regular Fluoride Toothpaste
Colgate® Total
Figure 1. Overnight (12 hours) post brushing organoleptic scores compared to baseline
Unpleasant Breath
Neutral Breath
Org
anol
epti
c Sc
ores
7.35
7.346.49
4.49
Pleasant Breath
* statistically signifi cant (p<0.001) reduction of organoleptic scores
*
30.8 %
Supplementary Study Information
Study participants
80 adult subjects with good dental health were recruited for the study
Methods
Subjects randomly assigned to one of two treatment groups. Oraganoleptic scores were recorded at baseline and after 3 weeks by a panel of four trained and calibratedjudges using a nine-point organoleptic hedonic scale.
Conclusion
The Colgate® Total with Dual Zinc plus Arginine toothpaste containing zinc (zinc oxide, zinc citrate) 0.96%, 1.5% arginine and 1450 ppm fl uoride as sodium fl uoride in a silica base provides signifi cantly greater reduction in oral malodor as compared to a regular fl uoride toothpaste containing 1450 ppm fl u-oride as sodium fl uoride in a silica base 12 hours post-brushing (overnight) after 3 weeks of product use.
Products under Investigation
• Test toothpaste 1: zinc (zinc oxide, zinc citrate) 0.96%, 1.5% Arginine and 1450 ppm fl uoride (Colgate® Total with Dual Zinc plus Arginine; Colgate-Palmolive Company, New York, NY)
• Control toothpaste: regular fl uoride toothpaste containing 1450 ppm fl uoride (MaxFresh Tea; Colgate-Palmolive Company, New York, NY)
Trial Procedure
Evaluation of oral malodor
Evaluation of oral malodor 12 hours after last product use
Brush with assigned toothpaste 2x daily for 1 min
Baseline 3 weeks
Further published studies with these products: 1. Delgado et al, J Clin Dent, accepted for publication 20182. Prasad K et al, J Clin Dent, accepted for publication 20183. Manus L et al, J Clin Dent, accepted for publication 20184. Lee C et al, J Clin Dent, accepted for publication 2018
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