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خلاصه. هورمونهای مشتق از اسید امینه. هورمونهای کاتکل امینها هورمونهای تیروئید هورمونهای انسولین و گلوکاگن. Out line (catechol amines. Introduction Structure Biosynthesis Secretion Regulation Catabolism Biology and cellular Action Disorders. Adrenal medulla Hormones. - PowerPoint PPT Presentation
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Out line (catechol amines
IntroductionStructureBiosynthesisSecretionRegulationCatabolismBiology and cellular ActionDisorders
Action
A-adrenergic R(Phentalamine,phenoxybezamine,ergotalkaloids
ß-adrenergicR.(Propanolol,Dichlorisoproternol,pronethalol)(glycogenesis,gluconeogenesis(Amylase↑)Relaxation of uterine musculature, T.G to FFA, blood
pressure)
Out line (thyroid)
IntroductionStructure BiosynthesisSecretionRegulationCatabolismBiology and cellular ActionDisorders
Thyroid Hormones
T3T4Introduction-Hormone effect (Growth and differentiation)-Target tissue-Iodid metabolismRDA(Recommended daily allowance) 250-500µg,
0.1% KI 150-200µg/d absorbtionMetabolic effects Behavior changes ,Cardiac out
put, growth, digestive ,Oxygen consumptionHyper and Hypo thyroid-
www.hsc.missouri.edu/~daveg/thyroid/thy_dis.html
EXAMPLES OF THYROID DISEASES
1° Hypothyroidism Hyperthyroidism
Thyroglobulin(Biosynthesis)
-Biosynthesis of ThyroglobulinConcentration of iodide(Perclorates,pertectates, perrahnatesThiocynates , ovabaeine
1-oxidation of I –2-odination of thyrosine3-Coupeling(DIT,MIT), T3,T4)4-Storage of TG in the Follicular Lumen5-pinocytosis ,phagocytosis6-Hydrolysis7-Secretion into bloodMain four compound(Tg,TPO,H2o2Iodothroglobolin)
134 Thyrosine Residue(25-35)4 of them active(5,2553,2567,2746)
Plasma proteins carriers
TBG(70-75%,T4,T3)TBPA(25-30% T4)Albumin(5-10%T4,25-30% T3)
0.04T4,0.4%T3 are free.Deficiency reported,1/2000)Pregnancy
Biological and Molecular action
-IntroductionRegulation of Oxygen
consumption,Regulation of metabolism Carbohydrate, lipids, Proteins,
Catabolism of Growth factorsGrowth and differentiation, Metabolism
pathwayMechanism of the effect1-Increase the Na+/K+ATPase pump2- binding to nuclear receptor and its
effect on the expression of Gene
-Thyroid receptors
Disorders of thyroid hormones
-Hyperthyroid-Graves disease-Nodular thyroid disease-Thyroiditis-HypothyroidismLaboratory Evaluation
EXAMPLES OF THYROID DISEASES
www.hsc.missouri.edu/~daveg/thyroid/thy_dis.html
Congenital HypothyroidismJuvenile Hypothyroidism
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