2014 Conte Annual Scientific Retreat Agenda

The   Conte   Center   for   Computational   Neuropsychiatric   Genomics   is   a   cross-­‐disciplinary   and  multi-­‐institutional   effort   involving   seven  universities   that   include  The  University  of  Chicago,  Northwestern  University,  The  University  of  Illinois  at  Chicago,  Harvard  University,  Stanford  University,  Columbia  University,  and  the  University  of  Haifa   in  Israel.  The  overarching  goal  of  the  Center  is  to  identify  the   genetic   and   environmental   risk   and   protective   factors   that   underlie   mental  health   and   disease,   including   autism,   schizophrenia,   bipolar   disorder,   major  depression,  anxiety  disorder,  and  psychopathology.  Our  team  develops  and  applies  drastically   new   mathematical   and   computational   strategies   to   infer   causal  relationships   among   genetic   variation,   environmental   variables   and   psychiatric  phenotypes.  We  achieve  this  by  combining  the  statistical  power  of  large  genetic  and  pharmacogenomic  datasets,  text-­‐mining  strategies  and  review  of  electronic  medical  records.   Computational   predictions   are   then   experimentally   validated   using   high-­‐throughput   biochemical,   genomic   and   proteomic   strategies,   as   well   as   the  development  of  in  vitro  and  animal  models.    

CONTE  LEADERSHIP    

ALTMAN,  Russ     Stanford  University  APRISON,  Barry       The  University  of  Chicago  COOK,  Edwin  H.  Jr.     University  of  Illinois  at  Chicago  COX,  Nancy         The  University  of  Chicago  GERSHON,  Elliot       The  University  of  Chicago      GROSSMAN,  Robert     The  University  of  Chicago  KOHANE,  Isaac       Harvard  University  KUMAR,  Ravinesh       The  University  of  Chicago  LAHEY,  Benjamin       The  University  of  Chicago  LIU,  Chunyu       University  of  Illinois  at  Chicago  MORIMOTO,  Richard     Northwestern  University  NICOLAE,  Dan       The  University  of  Chicago  PELEG,  Mor       University  of  Haifa  RABADAN,  Raul     Columbia  University  RZHETSKY,  Andrey     The  University  of  Chicago  SHAH,  Nigam       Stanford  University  STRANGER,  Barbara     The  University  of  Chicago  WHITE,  Kevin       The  University  of  Chicago  

CONTE  SCIENTIFIC  ADVISORY  BOARD  2014    

DENNY,  Joshua       Vanderbilt  University  EGGAN,  Kevin       Harvard  University  RICE,  John         Washington  University  in  St.  Louis  SEBAT,  Jonathan       University  of  California  San  Diego  SULLIVAN,  Patrick     University  of  North  Carolina  at  Chapel  Hill  

SCHEDULE  AT  A  GLANCE    Mon,  May  5,  2014  (Hyatt  Hyde  Park,  5225  S  Harper  Ave)  7:00-­‐9:00     Kick-­‐Off  Reception          Tues,  May  6,  2014  (International  House  at  The  University  of  Chicago,  1414  E  59th  St)    8:30-­‐9:15     Continental  Breakfast    (Home  Room)          9:15-­‐9:30       Opening  Remarks  (Assembly  Hall)  

Welcome  (Ravinesh  Kumar)  /  Round-­‐table  Introductions  9:30-­‐11:00     Project  and  Core  Updates  and  Highlights    (Assembly  Hall)  

9:30-­‐10:00   Project  4:  Integrated  Informatics  (Andrey  Rzhetsky,  UChicago)  10:00-­‐10:30   Project  3:  Molecular  Networks  (Nancy  Cox,  UChicago)  10:30-­‐11:00   Project  2:  Electronic  Health  Records  (Nigam  Shah,  Stanford)  

11:00-­‐11:10     Coffee  Break  11:10-­‐12:10     Project  and  Core  Updates  and  Highlights  (Assembly  Hall)  

11:10-­‐11:40   Project  1:  Pharmacogenomics  (Russ  Altman,  Stanford)     11:40-­‐12:10   Core  C:  Mental  Health  Phenotypes  (Robert  Gibbons,  UChicago)  12:10-­‐12:15     Rapid  Fire  Poster  Highlights  12:15-­‐1:00     Lunch  (Home  Room)  /  Poster  Session  (Assembly  Hall)  1:00-­‐1:30     Open  Meetings    1:30-­‐3:00     Core  Updates  and  Highlights  (Assembly  Hall)  

1:30-­‐2:00   Core  C:  RNAi  in  Human  Neurons  (Kevin  White,  UChicago)  2:00-­‐2:30   Core  C:  CRISPR  in  C.  Elegans  (Rick  Morimoto,  Northwestern)  2:30-­‐3:00   Core  B:  Conte  Data  Cloud  (Robert  Grossman,  UChicago)  

3:00-­‐3:05     Rapid  Fire  Platform  Highlights  (Assembly  Hall)  3:05-­‐3:15     Coffee  Break  3:15-­‐4:15     P50  Next  Round  Planning  Meeting  (Coulter  Lounge)  3:15-­‐4:15     Conte  Cloud  Workshop  (Assembly  Hall)  4:15-­‐6:00     Open  Meetings    6:00-­‐9:00     Dinner  (Pizza  Capri,  1501  East  53rd  St,  Chicago)  Wed,  May  7,  2014  (International  House  at  The  University  of  Chicago,  1414  E  59th  St)  8:30-­‐9:30       Continental  Breakfast      9:30-­‐9:45     Core  Updates  and  Highlights  (Assembly  Hall)  

9:30–9:45   Core  A:  Education  and  Outreach  (Barry  Aprison,  UChicago)  9:45-­‐11:00     Conte  Trainee  Talks  (Assembly  Hall)     9:45-­‐10:00   Kaanan  Shah  (UChicago)         10:00-­‐10:15   Bethany  Percha  (Stanford)     10:15-­‐10:30     Rachel  Melamed  (Columbia)     10:30-­‐10:45   Assaf  Gottlieb  (Stanford)       10:45-­‐11:00   Judith  Somekh  (UHaifa)  11:00-­‐11:15     Coffee  Break  11:15-­‐12:00     Conte  Associates  Talks  (Assembly  Hall)     11:15-­‐11:30   Lea  Davis  (UChicago)     11:30-­‐11:45   Sek  Won  Kong  (Harvard)     11:45-­‐12:00   Steven  Bagley  (Stanford)        12:00-­‐1:00     Lunch    12:30-­‐1:00     Scientific  Advisory  Board  (SAB)  Meeting  (Tiffin  Room)  1:00-­‐1:30     SAB  Evaluation  Meeting  with  Project/Core  Leaders  (Tiffin)  1:30       Closing  Reception  (Home  Room)  

FULL  SCHEDULE    Monday  May  5,  2014  Kick-­‐off  Reception,  Hyatt  Hyde  Park  |  5225  S.  Harper  Ave,  Chicago  IL    Tuesday  May  6,  2014  International  House  at  The  University  of  Chicago  |  1414  E.  59th  St,  Chicago  IL    8:30-­‐9:15       Continental  Breakfast    (Home  Room)            9:15-­‐9:30       Opening  Remarks  (Assembly  Hall)    Welcome  Ravinesh  Kumar,  PhD,  Conte  Director  of  Research,  The  University  of  Chicago      Round-­‐table  Introductions    9:30-­‐11:00  am   Project  and  Core  Updates  and  Highlights    (Assembly  Hall)  9:30-­‐10:00  am  Project  4:  Integrated  Modeling  of  Multiple  Data  Types  Andrey  Rzhetsky,  PhD,  The  University  of  Chicago    10:00-­‐10:30  Project  3:  Data  Integration  and  Disease  Risk  Modeling  in  the  Context  of  Molecular  Networks  and  Genetic  Associations  Nancy  Cox,  PhD,  The  University  of  Chicago    10:30-­‐11:00  Project  2:  Modeling  the  Temporal  Succession  of  Phenotypes  and  Environmental  Cues    Nigam  Shah,  PhD,  Harvard  University    11:00-­‐11:10     Coffee  Break    (Assembly  Hall)    11:10-­‐12:10     Project  and  Core  Updates  and  Highlights    (Assembly  Hall)    11:10-­‐11:40    Project  1:    A  Comprehensive  Network  of  Neuropsychiatric  Drugs-­‐Genes-­‐Phenotypes    Russ  Altman,  MD,  PhD,  Stanford  University    11:40-­‐12:10  Core  C:  The  Future  of  Mental  Health  Measurements:  Computerized  Adaptive  Tests  Robert  Gibbons,  PhD,  The  University  of  Chicago    12:10-­‐12:15       Rapid  Fire  Poster  Highlights  (Assembly  Hall)    12:15-­‐1:00       Lunch  (Home  Room)  |  Poster  Session  (Assembly  Hall)      

FULL  SCHEDULE  (continued)    1:00-­‐1:30     Open  Meetings      1:  30-­‐3:00     Core  Updates  and  Highlights  (Assembly  Hall)          1:30-­‐2:00    Core  C:  Combinatorial  RNAi  in  Human  Neurons  Kevin  White,  PhD,  The  University  of  Chicago    2:00-­‐2:30    Core  C:  CRISPR  Technology  in  C.  Elegans  Rick  Morimoto,  PhD,  Northwestern  University    2:30-­‐3:00    Core  B:  High  Performance  Informatics  &  Conte  Protected  Data  Cloud  Robert  Grossman,  PhD,  The  University  of  Chicago    3:00-­‐3:05       Rapid  Fire  Platform  Highlights  (Assembly  Hall)    3:05-­‐3:15     Coffee  Break    (Assembly  Hall)    3:15-­‐4:15     P50  Next  Round  Planning  Meeting    (Coulter  Room)    3:15-­‐4:15     Conte  Cloud  Workshop    (Assembly  Hall)    4:15-­‐6:00     Open  Meetings        6:00-­‐-­‐9:00     Dinner  Pizza  Capri  (1501  East  53rd  St,  Chicago)    Tuesday  May  6,  2014  International  House  at  The  University  of  Chicago  |  1414  E.  59th  St,  Chicago  IL    8:30-­‐9:30       Continental  Breakfast    (Home  Room)            9:30-­‐9:45       Core  Updates  and  Highlights  (Assembly  Hall)    9:30-­‐9:45    Core  A:  Education,  Training  and  Outreach  Initiatives    Barry  Aprison,  PhD,  The  University  of  Chicago    9:45-­‐11:00       Conte  Trainee  Talks  (Assembly  Hall)    9:45-­‐10:00    Unique  Patterns  of  Variability  Around  Mendelian  Genes    Kaanan  Shah,  PhD,  The  University  of  Chicago  

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FULL  SCHEDULE  (continued)    10:00-­‐10:15    A  Fast  and  Flexible  Approach  to  the  Discovery  of  Relationships  in  Biomedical  Text  Bethany  Percha,  PhD  Candidate,  Stanford  University    10:15-­‐10:30    Discovery  of  Seasonal  Patterns  in  Incidence  of  Disease  from  EHR  Data  and  Comparison  Between  Hospital  Systems  Rachel  Melamed,  PhD  Candidate,  Columbia  University    10:30-­‐10:45    Drug  Side  Effects:  How  to  Predict  Them  and  How  to  Deal  with  So  Many  Predictions  Assaf  Gottlieb,  PhD,  Stanford    10:45-­‐11:00    Using  Dynamic  Model-­‐Based  Systems  Biology  for  Exploring  the  ASD-­‐IBD  Connection  Judith  Somekh,  PhD,  University  of  Haifa,  Israel    11:00-­‐11:15     Coffee  Break    (Assembly  Hall)    11:15-­‐12:00     Conte  Associates  Talks    (Assembly  Hall)    11:15-­‐11:30    Defining  the  Inverse  Axis  of  Risk  in  Complex  Traits  Lea  Davis,  PhD,  The  University  of  Chicago    11:30-­‐11:45  Reducing  False  Positive  Incidental  Findings  with  Ensemble  Genotyping  and  Logistic  Regression-­‐Based  Variant  Filtering  Methods  Sek  Won  Kong,  PhD,  Harvard  University    11:45-­‐12:00    Comparing  Disease  Synergism  and  Protection  in  Two  Electronic  Medical  Record  Systems  using  Inferred  Genetic  Overlap    Steven  Bagley,  MD,  Stanford  University    12:00-­‐1:00       Lunch  (Home  Room)    12:30-­‐1:00       Scientific  Advisory  Board  (SAB)  Meeting  (Tiffin  Room)      1:00-­‐1:30       SAB    Evaluation  Mtg    w/  Project  &  Core  Leaders  (Tiffin  Rm)          1:30         Closing  Reception  (Home  Room)            

POSTERS  AT  A  GLANCE      (Poster  Board  #)    #1   ALLIEY-­‐RODRIGUEZ,  Ney   The  University  of  Chicago    

Copy Number Variants and their Impact on Counseling for Mental Disorders #2 APRISON, Barry The  University  of  Chicago     Conte Center Education, Outreach, and Training Initiatives #3 ARCHER, Chase The  University  of  Chicago The MicroWestern Array for Analysis of Protein Targets #4 CHEN, Chao Central  South  University  China  

Integration of miRNA-mRNA Networks to Elucidate the Molecular Complexity of Psychiatric Disorders

#5 CHEN, Lin The  University  of  Chicago  

A Unified Framework for Two-Stage Gene-Environment Interaction Tests with Adaptive Filtering

#6 CIRYAM, Prajwal Northwestern  University  

Proteome Metastability in Health, Aging, and Disease #7 COOK, Edwin H., Jr. University  of  Illinois  at  Chicago  

Heterogeneity in 5-Httlpr Genotype-Phenotype Effects #8 COOK, Edwin H., Jr. University  of  Illinois  at  Chicago   Pharmacogentics Study of Serotonin Transporter and 5HT2A Genotype in Autism #9 FORDE, Martin The  University  of  Chicago  

High-Throughput Combinatorial RNAi Screening in Human Neurons to Validate Candidate Genes for Neuropsychiatric Disorder

#10 GILETA, Alex The  University  of  Chicago   Genome-wide Association Study of Incentive Salience in Outbred Rats #11 GRENNAN, Kay The  University  of  Chicago  

Molecular Network Analysis Enhances Understanding of the Biology of Mental Disorders

#12 GUTER, Steve University  of  Illinois  at  Chicago  

The Autism Diagnostic Observation Schedule, Module 4: Revised Algorithm and Standardized Severity Scores-A Replication Study in an NDAR sample

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#13 GUTER, Steve University  of  Illinois  at  Chicago  National Database for Autism Research (NDAR): An Overview

#14 IM, Hae Kyung The  University  of  Chicago  

Predicting the Transcriptome to Probe the Biology of Complex Traits - PrediXcan #15 LI, Jian Northwestern  University   HSF1 Controls Two Proteostasis Networks Essential for Development #16 LYTTLE, Christopher The  University  of  Chicago Introduction to MarketScan®    

#17 OPAL, Mark The  University  of  Chicago    RAMAKER, Marcia Selective Serotonin 2C Receptor Antagonists Induce Fast-Acting Antidepressant Effects and Neuronal Remodeling

#18 PATTERSON, Maria The  University  of  Chicago

The Conte Protected Data Cloud (Conte-PDC): A Secure Cloud Architecture Enabling Analysis of Big Data for the Neuropsychiatric Genomics Community

#19 PRILUTSKY, Daria Harvard  University    

Gene Expression as a Higher-Throughput Readout for iPSC-Derived Neurons to Study Autism

#20 SENGUPTA, Subhajit NorthShore  University  Health  System  

Are Normal Cells Mosaic?-A Statistical Model for Cell Genomes #21 SHAH, Nigam Stanford  University  

Common & Distinct Patient-Reported Symptoms in Autism & Schizophrenia: Preliminary Findings from PatientsLikeMe, an Online Patient-Powered Research Network (PPRN)

#22 ZHU, Yitan NorthShore  University  Health  System

Zodiac: A Comprehensive Depiction of Genetic Interactions in Cancer by Integrating TCGA Data

PARTICIPANT LIST  ALLIEY-­‐RODRIGUEZ,  Ney   The  University  of  Chicago          Research  Associate     nalliey@bsd.uchicago.edu    ALTMAN,  Russ       Stanford  University          Professor       russ.altman@stanford.edu    APRISON,  Barry     The  University  of  Chicago        Education  Director     baprison@bsd.uchicago.edu    ARCHER,  Chase     The  University  of  Chicago  Scientific  Director     ctarcher@uchicago.edu    BAGLEY,  Steven     Stanford  University              Research  Engineer     steven.bagley@stanford.edu    BLAIR,  David       The  University  of  Chicago        MD/PhD  Candidate     daveblair@uchicago.edu    BROWN,  Adam     The  University  of  Chicago  PhD  Student       asbrown16@gmail.com    CAMACHO,  Camilla     The  University  of  Chicago  PREP  Scholar       cbcamacho@peds.bsd.uchicago.edu    CHEN,  Chao       University  of  Illinois  at  Chicago      Associate  Professor     chenchaor@gmail.com    CHEN,  Lin       The  University  of  Chicago  Assistant  Professor     lchen@health.bsd.uchicago.edu    CIRYAM,  Prajwal     Northwestern  University  MD/PhD  Student     p-­‐ciryam@fsm.northwestern.edu    COOK,  Edwin       University  of  Illinois  at  Chicago      Professor       ecook@psych@uic.edu    COX,  Nancy       The  University  of  Chicago          Professor       ncox@bsd.uchicago.edu    DAVIS,  Lea       The  University  of  Chicago  Research  Associate     lea.k.davis@gmail.com          

DENNY,  Joshua     Vanderbilt  University  Associate  Professor     josh.denny@vanderbilt.edu    FORDE,  Martin     The  University  of  Chicago  Research  Technologist   mforde84@gmail.com    FOSTER,  Ian       The  University  of  Chicago  Professor       foster@anl.gov    GERSHON,  Elliot     The  University  of  Chicago          Professor       egershon@yoda.bsd.uchicago.edu    GIBBONS,  Robert     The  University  of  Chicago        Professor       rdg@uchiacgo.edu    GILETA,  Alex       The  University  of  Chicago    PhD  Student       alex.gileta@gmail.com    GONZALES,  Natalia     The  University  of  Chicago  Graduate  Student     ngon@uchicago.edu    GOTTLIEB,  Assaf     Stanford  University  Postdoctoral  Fellow     assafgo@stanford.edu    GREENWAY,  Matthew   The  University  of  Chicago        Research  Programmer   mgreenway@uchiago.edu    GREENAN,  Kay     The  University  of  Chicago        Research  Technologist   kgrennan@uchicago.edu    GROSSMAN,  Robert     The  University  of  Chicago        Professor       robert.grossman@uchicago.edu    GUTER,  Stephen     University  of  Illinois          Project  Coordinator     sguter@psych.uic.edu    HEATH,  Allison     The  University  of  Chicago  Research  Associate     aheath@uchicago.edu    IM,  Hae  Kyung     The  University  of  Chicago  Research  Associate     haky@uchicago.edu    JI,  Yuan       The  University  of  Chicago  Associate  Professor     YJi@health.bsd.uchicago.edu    KONG,  Sek  Won     Harvard  University          Associate  Scientist     swkong@enders.tch.harvard.edu  

 KUMAR,  Ravinesh     The  University  of  Chicago        Research  Director     rakumar@uchicago.edu    LAHEY,  Benjamin     The  University  of  Chicago        Principal  Investigator   blahey@heath.bsd.uchiago.edu    LI,  Jian         Northwestern  University        Postdoctoral  Fellow     jian.li@northwestern.edu    LIU,  Chun-­‐Yu       University  of  Illinois  at  Chicago      Associate  Professor     liucy@uic.edu    LYTTLE,  Christopher   The  University  of  Chicago  Director,  Methods  Core   clyttle@bsd.uchicago.edu    MELAMED,  Rachel     Columbia  University          PhD  Candidate     rdm2114@columbia.edu    MORIMOTO,  Richard   Northwestern  University        Professor       r-­‐morimto@northwestern.edu    NICOLAE,  Dan     The  University  of  Chicago        Professor       nicolae@galton.uchicago.edu    OPAL,  Mark       The  University  of  Chicago  Postdoctoral  Fellow     mopal@uchicago.edu    PALMER,  Abraham     The  University  of  Chicago        Associate  Professor     aap@uchicago.edu    PATTERSON,  Maria     The  University  of  Chicago  Postdoctoral  Fellow     maria.t.patterson@gmail.com    PERCHA,  Bethany     Stanford  University        PhD  Candidate     blpercha@stanford.edu    PITT,  Jason       The  University  of  Chicago  PhD  Student       pittjj@uchicago.edu    PRILUTSKY,  Daria     Harvard  University        Postdoctoral  Fellow     Daria_Prilutsky@hms.harvard.edu    RAMAKER,  Marcia     The  University  of  Chicago  Postdoctoral  Fellow     mjramaker@uchicago.edu      

REED,  Patrick       The  University  of    Chicago  PhD  Student       pjr314@gmail.com    RICE,  John       University  of  Washington  in  St.  Louis          Professor       john@zork.wustl.edu    RZHETSKY,  Andrey     The  University  of  Chicago      Professor       arzhetsk@medicine.bsd.uchicago.edu      SEBAT,  Jonathan     University  of  California  San  Diego  Associate  Professor     jsebat@ucsd.edu    SENGUPTA,  Subhajit     NorthShore  University  HealthSystem  Postdoctoral  Fellow     subhajit06@gmail.com    SHAH,  Kaanan     The  University  of  Chicago  Postdoctoral  Fellow     kshah2@medicine.bsd.uchicago.edu    SHAH,  Nigam       Stanford  University        Assistant  Professor     nigam@stanford.edu    SOMEKH,  Judith     University  of  Haifa,  Israel  Postdoctoral  Fellow     ysomekh@gmail.com    STALLCUP,  Kathyrn     Chicago  Biomedical  Consortium  Executive  Director     k-­‐stallcup@northwestern.edu    SULLIVAN,  Patrick     The  University  of  North  Carolina  at  Chapel  Hill  Professor       patrick_sullivan@med.unc.edu    WANG,  Kanix       The  University  of  Chicago  PhD  Candidate     kanixwang@uchicago.edu    WHITE,  Kevin     The  University  of  Chicago    Professor         kpwhite@uhicago.edu    ZHU,  Yitan       NorthShore  University  HealthSystem  Research  Scientist     zhuyitan@gmail.com      

 CONTE  PROTECTED  DATA  CLOUD  WORKSHOP    Allison  Heath,  Ph.D.  and  Ney  Alliey-­‐Rodriguez,  Ph.D.  (The  University  of  Chicago)    May  6,  2014;  3:15-­‐4:15  pm    This  workshop  will  introduce  participants  to  the  fully-­‐up  and  operational  Conte  Cloud  that  is  available  to  all  Conte  investigators.    The  Conte  Cloud  is  a  Bionimbus  based  cloud  computing  infrastructure  that  is  currently  comprised  of  200  cores  and  225  terabytes  of  raw  storage.  Topics  discussed  at  this  working  group  may  include:  

• What  resources  are  available?  How  to  gain  access  to  the  Conte  Cloud?  How  to  upload  your  own  data  to  the  Conte  Cloud?  

• How  does  cloud  computing  differ  from  standard  clusters;  how  does  the  Conte  Cloud  differ  from  other  cloud  resources?;  security  and  computing  over  protected  data  

• Basic  workflow;  logging  into  the  Open  Science  Data  Cloud  console;  launching  VM;  SSH  to  VM;  computing  

• Discussion  of  data  sets  available  to  all  users:  metadata  and  query  services  • What  analysis  programs  and  tools  are  of  general  interest  to  the  Conte  

community?;  interest  in  community-­‐maintained  VMS?  • Can  we  implement  a  pipeline  for  all  NHGRI  GWAS  result  to  test  for  

enrichment  with  every  GWAS?  • General  discussion  on  next  steps,  expansion,  and  new  features

ACKNOWLEDGMENTS    

Funding  Agencies  • National  Institute  of  Health;  P50MH9467  • Chicago  Biomedical  Consortium;  L-­‐004  • Psychiatric  Genetics  Training  Grant;  NIH  T32  GM07197    

Scientific  Program    • Ravinesh  Kumar,  Russ  Altman,  Kevin  White,  Andrey  Rzhetsky  

 Program  Booklet  

• Ravinesh  Kumar    

Scientific  Advisory  Board  • John  Rice,  Patrick  Sullivan,  Jonathan  Sebat,  Kevin  Eggan,  Joshua  Denny    

Event  Management  • Patty  Coen,  Great  Chicago  Events  • Elena  Menarini,  Great  Chicago  Events  

 International  House  

• Jeanette  Drake    • Patricia  Guadalupe  Nieves    

Audio-­‐Visual  Assistance  • Anthony  Vieceli,  Plus  One  AV  

 Catering  

• Rachel  Brown,  Phoenix  Catering    

Pizza  Capri  • Max  Taleb  

 Hyatt  Place  

• Briana  Pickett    

Program  Editing  • Martin  Forde