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2009 research priorities. Cleavage degeneracy partially randomized libraries in vitro Cre, Mso, mCre, mMso (Hui) single site scans by recombination induction in vivo (Umut, Hui) end capture from genomic DNA/Solexa sequence (Stefan) - PowerPoint PPT Presentation
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2009 research priorities
Cleavage degeneracy
- partially randomized libraries in vitro Cre, Mso, mCre, mMso (Hui)
- single site scans by recombination induction in vivo (Umut, Hui)
- end capture from genomic DNA/Solexa sequence (Stefan)
- insertion site tagging/sequencing (Stefan w/H-P’s lab,Byoung).
New designs for disease gene/Anopheles targets (Umut)
More active/’up’ mutant versions of Mso (Hui)
Benchmarking of native/engineered HEG’s
- expression/stability/toxicity as f(activity)/in vivo sites above (Stefan)
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