1. Systemic Lupus Erythematosus (SLE) 2. Epidemiology of SLE

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1. Systemic Lupus Erythematosus (SLE)

2. Epidemiology of SLE

Tufts OpenCourseWare © 2007 Tufts University

Systemic Lupus Erythematosus (SLE)

OCW: Musculoskeletal Pathophysiology (R. A. Kalish) Page - 1

3. Pathogenesis of SLE

4. Pathogenesis of SLE

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Systemic Lupus Erythematosus (SLE)

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5. Pathogenesis – Immunologic Abnormalities

6. B cells in SLE

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Systemic Lupus Erythematosus (SLE)

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7. T cells in SLE

8. Pathogenesis – Immunologic factors

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Systemic Lupus Erythematosus (SLE)

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9. Observed immune abnormalities in SLE

10. Principle of IndirectImmunofluorescence

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Systemic Lupus Erythematosus (SLE)

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11. Clinically relevant autoantibodies in SLE

12. Mechanism of tissue damage in SLE

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Systemic Lupus Erythematosus (SLE)

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13. Clinical Features of SLE

14. Systemic Lupus Erythematosus (SLE): Slide 15

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Systemic Lupus Erythematosus (SLE)

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15. Cutaneous Manifestations

16. Cutaneous manifestations

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Systemic Lupus Erythematosus (SLE)

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17. Cutaneous manifestations

18. Pulmonary manifestations

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Systemic Lupus Erythematosus (SLE)

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19. Cardiac manifestations

20. Hematologic manifestations

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Systemic Lupus Erythematosus (SLE)

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21. Gastrointestinal manifestations

22. Neuropsychiatric (?25-50%) – Functional vs organic dif...

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Systemic Lupus Erythematosus (SLE)

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23. Neuropsychiatric

24. Lupus nephritis (50%)

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Systemic Lupus Erythematosus (SLE)

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25. Lupus Nephritis – clinical presentation

26. Classification of SLE with Reference to Glumerulonephritis...

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27. Treatment of Lupus Nephritis – NIH Data

28. 1982 revised criteria for classification of systemic lupus e...

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Systemic Lupus Erythematosus (SLE)

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29. Management of SLE

30. Future Therapies

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