1 Human Anatomy, First Edition McKinley & O'Loughlin Chapter 14 Lecture Outline: Nervous...

1

Human Anatomy, First EditionMcKinley & O'Loughlin

Chapter 14 Lecture Outline:Nervous Tissue

14-2

The Nervous System The nervous system is the body’s

primary communication and control system.

The nervous system can be divided according to structural and functional categories.

14-3

Nervous System: Structural Organization

Structural subdivisions of the nervous system: Central nervous system (CNS)

brain and spinal cord Peripheral nervous system (PNS)

cranial nerves (nerves that extend from the brain)

spinal nerves (nerves that extend from the spinal cord)

ganglia (clusters of neuron cell bodies located outside the CNS)

4

14-5

Nervous System: Functional Organization

Functional divisions of the nervous system:

Sensory division — receives sensory information (input) from receptors and transmits this information to the CNS.

Motor (or efferent) division — transmits motor impulses (output) from the CNS to muscles or glands.

6

14-7

Sensory Division

The sensory division is subdivided into two components:

Somatic sensory components are the general somatic senses—touch, pain, pressure, vibration, temperature, and proprioception.

Visceral sensory components transmit nerve impulses from blood vessels and viscera to the CNS. The visceral senses primarily include temperature and stretch (of the organ wall).

14-8

Motor DivisionThe motor division is subdivided into two

components: The somatic motor component (somatic nervous

system; SNS) conducts nerve impulses from the CNS to skeletal muscles.

also known as the voluntary nervous system The autonomic motor component (autonomic

nervous system; ANS) innervates internal organs, regulates smooth muscle, cardiac muscle, and glands.

also known as the visceral motor system or involuntary nervous system

14-9

Nerve Cells Two distinct cell types form nervous tissue.

Neurons, which are excitable cells that initiate and transmit nerve impulses

Glial cells, which are nonexcitable cells that support and protect the neurons

14-10

Characteristics of Neurons Neurons have a high metabolic rate. Neurons have extreme longevity. Neurons typically are non-mitotic.

14-11

Neuron Structure Neurons come in all shapes and sizes, but all

neurons share certain basic structural features.

A typical neuron has a cell body, dendrites, and axons.

14-12

Neuron Structure – Cell Body The cell body serves as the neuron’s

control center and is responsible for receiving, integrating, and sending nerve impulses.

14-13

Neuron Structure – Dendrites Dendrites tend to be shorter, smaller

processes that branch off the cell body. Some neurons have only one dendrite, while

others have many. Dendrites conduct nerve impulses toward the

cell body; they receive input and then transfer it to the cell body for processing.

The more dendrites a neuron has, the more nerve impulses that neuron can receive from other cells.

14-14

Neuron Structure – Axon The larger, typically longer nerve cell

process emanating from the cell body is the axon, sometimes called a nerve fiber.

Most neurons have only one axon. The axon transmits a nerve impulse

away from the cell body toward another cell.

15

16

14-17

Classifications of Neurons Neurons vary widely in morphology and

location. They can be classified according to either their

structure or their function. Neurons can be classified according to the

number of processes extending from the cell body.

unipolar neuron has a single process bipolar neurons have two processes multipolar neurons have three or more processes

18

14-19

Interneurons Interneurons, or association neurons, lie

entirely within the CNS and are multipolar. They receive nerve impulses from many other

neurons and carry out the integrative function of the nervous system.

Thus, interneurons facilitate communication between sensory and motor neurons.

20

21

14-22

Glial Cells Sometimes referred to as neuroglia, occur

within both the CNS and the PNS. Glial cells are smaller and capable of mitosis. Glial cells do not transmit nerve impulses. Glial cells physically protect and help nourish

neurons, and provide an organized, supporting framework for all the nervous tissue.

Glial cells far outnumber neurons. Glial cells account for roughly half the volume

of the nervous system.

23

24

25

14-26

Glial Cells of the CNS Astrocytes exhibit a starlike shape due to

projections from their surface. Astrocytes are the most abundant glial cells in

the CNS, and they constitute over 90% of the tissue in some areas of the brain.

Help form the blood-brain barrier (BBB) that strictly controls substances entering the nervous tissue in the brain from the bloodstream.

Regulate tissue fluid composition.

14-27

Functions of Glial Cells Forming a structural network. Replacing damaged neurons. Assisting neuronal development.

14-28

Myelination Neurolemmocytes also called Schwann

cells, are associated with PNS axons and are responsible for myelinating PNS axons.

Myelination is the process by which part of an axon is wrapped with a myelin sheath, a protective fatty coating that gives it glossy-white appearance.

The myelin sheath supports, protects, and insulates an axon.

14-29

Myelination No change in voltage can occur across the

membrane in the insulated portion of an axon. In the PNS, myelin sheaths form from

neurolemmocytes. In the CNS, they form from oligodendrocytes.

30

31

32

14-33

Mylenated vs. Unmylenated Axons In a myelinated axon, the nerve impulse

“jumps” from neurofibril node to neurofibril node and is known as saltatory conduction.

In an unmyelinated axon, the nerve impulse must travel the entire length of the axon, a process called continuous conduction.

A myelinated axon produces a faster nerve impulse.

14-34

Mylenated vs. Unmylenated Axons In an unmyelinated axon, a nerve

impulse takes longer to reach the end of the axon.

A myelinated axon also requires less energy (ATP) than does an unmyelinated axon.

Using continuous conduction, unmyelinated axons conduct nerve impulses from pain stimuli.

35

36

37

14-38

Regeneration of PNS Axons PNS axons are vulnerable to cuts, crushing

injuries, and other trauma. A damaged axon can regenerate, however, if

at least some neurilemma remains. PNS axon regeneration depends upon three

factors. the amount of damage neurolemmocyte secretion of nerve growth factors to

stimulate outgrowth of severed axons the distance between the site of the damaged axon

and the effector organ

14-39

Structure of a Nerve A nerve is a cable-like bundle of parallel axons. Like a muscle, a nerve has three successive

connective tissue wrappings. endoneurium - a delicate layer of loose connective

tissue perineurium - a cellular and fibrous connective tissue

layer that wraps groups of axons into bundles called fascicles

epineurium - a superficial connective tissue covering This thick layer of dense irregular fibrous connective tissue

encloses the entire nerve, providing both support and protection

40

41

14-42

Nerves Nerves are a component of the peripheral

nervous system. Sensory (afferent) nerves convey sensory

information to the CNS. Motor (efferent) nerves convey motor impulses

from the CNS to the muscles and glands. Axons terminate as they contact other neurons,

muscle cells, or gland cells. An axon transmits a nerve impulse at a

specialized junction with another neuron called synapse.

14-43

Synapses Presynaptic neurons transmit nerve

impulses along their axonal membranes toward a synapse.

Postsynaptic neurons conduct nerve impulses through their dendritic and cell body membranes away from the synapse.

Axons may establish synaptic contacts with any portion of the surface of another neuron, except those regions that are myelinated.

44

45

14-46

Electrical Synapses Electrical synapses are not very common in

mammals. In humans, these synapses occur primarily

between smooth muscle cells where quick, uniform innervation is essential.

Electrical synapses are also located in cardiac muscle.

14-47

Chemical Synapses The most numerous type of synapse is the

chemical synapse. It facilitates most of the interactions between

neurons and all communications between neurons and effectors.

At these junctions, the presynaptic membrane releases a signaling molecule called a neurotransmitter, such as acetylcholine (ACh).

Other types of neurons use other neurotransmitters.

48

49

14-50

Neurotransmitters Are released only from the plasma membrane

of the presynaptic cell. It then binds to receptor proteins found only on

the plasma membrane of the postsynaptic cell. A unidirectional flow of information and

communication takes place. Two factors influence the rate of conduction of

the impulse: the axon’s diameter and the presence (or absence) of a myelin sheath.

14-51

Neuronal Pools (or Neuronal Circuits or Pathways) Billions of interneurons within the CNS are

grouped in complex patterns called neuronal pools (or neuronal circuits or pathways).

Neuronal pools are defined based upon function, not anatomy, into four types of circuits:

converging diverging reverberating parallel-after-discharge

A pool may be localized, or its neurons may be distributed in several different regions of the CNS.

52